artesunate indications/contra

Stem definitionDrug idCAS RN
antimalarial agents, artemisinin related compounds 247 88495-63-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • artesunate
  • arinate
  • arsuamoon
  • arsumax
  • artesunic acid
  • cosunate
  • dihydroqinghasu hemsuccinate
  • Molecular weight: 384.43
  • Formula: C19H28O8
  • CLOGP: 2.93
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 100.52
  • ALOGS: -2.75
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.28 g O
0.28 g P

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Haemolytic anaemia 87.61 46.81 14 63 3195 3382587

Pharmacologic Action:

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SourceCodeDescription
ATC P01BE03 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, plain
ATC P01BF02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
ATC P01BF03 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
ATC P01BF04 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
ATC P01BF06 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
MeSH PA D000563 Amebicides
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
CHEBI has role CHEBI:38068 antimalarial

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Vivax malaria indication 27052006 DOID:12978
Falciparum malaria indication 62676009 DOID:14067

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.0 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
4025235 VUID
N0000179045 NUI
C0052432 UMLSCUI
D02482 KEGG_DRUG
60W3249T9M UNII
6459 INN_ID
4025235 VANDF
432410005 SNOMEDCT_US
432555000 SNOMEDCT_US
N0000171767 NDFRT
N0000179045 NDFRT
18346 RXNORM
009953 NDDF
CHEMBL361497 ChEMBL_ID
6917864 PUBCHEM_CID
C111789 MESH_SUPPLEMENTAL_RECORD_UI
C039726 MESH_SUPPLEMENTAL_RECORD_UI
DB09274 DRUGBANK_ID
CHEBI:63918 CHEBI

Pharmaceutical products:

None