sivelestat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| elastase inhibitors | 2452 | 127373-66-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
inhibitor of neutrophil elastase; structure given in first source
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | PMDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
| MeSH PA | D015842 | Serine Proteinase Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Acute lung injury | indication | 315345002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.84 | acidic |
| pKa2 | 7.84 | acidic |
| pKa3 | 13.07 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Neutrophil elastase | Enzyme | Ki | 6.70 | CHEMBL | IUPHAR | ||||
| Myeloblastin | Enzyme | IC50 | 6.47 | CHEMBL | |||||
| Neutrophil elastase | Enzyme | IC50 | 6.84 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D03788 | KEGG_DRUG |
| 201677-61-4 | SECONDARY_CAS_RN |
| C0130137 | UMLSCUI |
| CHEBI:32133 | CHEBI |
| CHEMBL76688 | ChEMBL_ID |
| CHEMBL3182314 | ChEMBL_ID |
| CHEMBL2107493 | ChEMBL_ID |
| DB12863 | DRUGBANK_ID |
| C069195 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6441 | IUPHAR_LIGAND_ID |
| 7703 | INN_ID |
| DWI62G0P59 | UNII |
| 107706 | PUBCHEM_CID |
Pharmaceutical products:
None