artemether indications/contra

Stem definitionDrug idCAS RN
antimalarial agents, artemisinin related compounds 245 71963-77-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • artemether
  • artemos
  • artenam
  • artesaph
  • dihydroartemisinin methyl ether
  • falcidol
  • gvither
  • malartem
  • beta-Artemether
quinghaosu derivative
  • Molecular weight: 298.38
  • Formula: C16H26O5
  • CLOGP: 3.05
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 46.15
  • ALOGS: -2.81
  • ROTB: 1

Drug dosage:

DoseUnitRoute
0.28 g O
0.12 g P
0.28 g O

Approvals:

DateAgencyCompanyOrphan
April 7, 2009 FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pyrexia 35.40 34.63 12 60 81103 3304684

Pharmacologic Action:

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SourceCodeDescription
ATC P01BE02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, plain
ATC P01BF01 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
MeSH PA D000871 Anthelmintics
CHEBI has role CHEBI:38068 antimalarial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000980 Antiplatyhelmintic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D003049 Coccidiostats
MeSH PA D012556 Schistosomicides

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Chloroquine Resistant Plasmodium Falciparum Malaria indication
Torsades de pointes contraindication 31722008
Hypokalemia contraindication 43339004
Bradycardia contraindication 48867003
Prolonged QT interval contraindication 111975006
Hypomagnesemia contraindication 190855004
Congenital long QT syndrome contraindication 442917000

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
4028721 VUID
N0000178417 NUI
C0052429 UMLSCUI
D02483 KEGG_DRUG
68911 PUBCHEM_CID
420578008 SNOMEDCT_US
420661005 SNOMEDCT_US
18572 MMSL
d05142 MMSL
4028721 VANDF
N0000178417 NDFRT
18343 RXNORM
009714 NDDF
CHEBI:195280 CHEBI
CHEMBL566534 ChEMBL_ID
C7D6T3H22J UNII
6458 INN_ID
C032942 MESH_SUPPLEMENTAL_RECORD_UI
DB06697 DRUGBANK_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
COARTEM HUMAN PRESCRIPTION DRUG LABEL 2 0078-0568 TABLET 20 mg ORAL NDA 17 sections
COARTEM HUMAN PRESCRIPTION DRUG LABEL 2 76413-154 TABLET 20 mg ORAL NDA 17 sections