sevoflurane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 2439 28523-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sevoflurane
  • sevoflo
  • sevofluran
  • sevofrane
  • sevorane
A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
  • Molecular weight: 200.06
  • Formula: C4H3F7O
  • CLOGP: 1.83
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -2.13
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 7, 1995 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 321.07 33.99 122 7283 28560 63453057
Myoglobin urine present 291.70 33.99 54 7351 718 63480899
Hypotension 288.12 33.99 244 7161 272360 63209257
Drug interaction 266.67 33.99 217 7188 228914 63252703
Delayed recovery from anaesthesia 228.71 33.99 44 7361 727 63480890
Hyperthermia malignant 225.26 33.99 44 7361 790 63480827
Anaphylactic shock 223.51 33.99 89 7316 23544 63458073
Unwanted awareness during anaesthesia 202.73 33.99 35 7370 303 63481314
Bronchospasm 202.26 33.99 76 7329 17204 63464413
Toxic encephalopathy 185.22 33.99 56 7349 6523 63475094
Anaesthetic complication 182.54 33.99 43 7362 1917 63479700
Cardiac arrest 180.63 33.99 120 7285 92425 63389192
Amylase increased 178.59 33.99 54 7351 6291 63475326
Bradycardia 162.60 33.99 103 7302 73124 63408493
Troponin increased 150.00 33.99 53 7352 10068 63471549
Blood potassium increased 126.00 33.99 55 7350 18254 63463363
Blood lactate dehydrogenase increased 119.82 33.99 57 7348 23059 63458558
Apnoea 115.03 33.99 41 7364 7981 63473636
Blood creatine phosphokinase increased 113.42 33.99 60 7345 30370 63451247
Hypercapnia 110.16 33.99 36 7369 5395 63476222
Oxygen saturation decreased 106.96 33.99 86 7319 88499 63393118
Tachycardia 102.63 33.99 95 7310 118061 63363556
Blood pressure decreased 102.46 33.99 74 7331 64948 63416669
Diabetes insipidus 94.30 33.99 27 7378 2598 63479019
Torsade de pointes 91.50 33.99 40 7365 13311 63468306
Neuromuscular block prolonged 89.50 33.99 19 7386 523 63481094
Breast cancer recurrent 88.95 33.99 29 7376 4312 63477305
Ventricular tachycardia 87.73 33.99 44 7361 19935 63461682
Anaphylactic reaction 85.82 33.99 67 7338 66033 63415584
Haemodynamic instability 84.68 33.99 34 7371 9156 63472461
Post procedural complication 79.10 33.99 39 7366 17035 63464582
Fatigue 78.35 33.99 7 7398 888021 62593596
Ventricular fibrillation 76.30 33.99 34 7371 11833 63469784
Rhabdomyolysis 76.09 33.99 53 7352 43898 63437719
Respiratory depression 74.67 33.99 35 7370 13680 63467937
Stress cardiomyopathy 73.60 33.99 31 7374 9419 63472198
Airway peak pressure increased 70.17 33.99 14 7391 281 63481336
Dystonia 68.31 33.99 33 7372 13786 63467831
Suspected product quality issue 67.71 33.99 13 7392 212 63481405
Alanine aminotransferase increased 66.95 33.99 71 7334 103699 63377918
Procedural hypotension 64.89 33.99 17 7388 1173 63480444
Hepatorenal failure 63.43 33.99 15 7390 679 63480938
Phrenic nerve paralysis 63.19 33.99 12 7393 184 63481433
Recurrence of neuromuscular blockade 60.36 33.99 11 7394 133 63481484
Anaesthetic complication neurological 59.63 33.99 12 7393 252 63481365
Cyanosis 59.16 33.99 32 7373 16903 63464714
Tracheal deviation 59.06 33.99 11 7394 151 63481466
Respiratory acidosis 58.96 33.99 24 7381 6691 63474926
Vasoplegia syndrome 58.90 33.99 17 7388 1682 63479935
Postoperative delirium 57.86 33.99 10 7395 87 63481530
Blood lactic acid increased 57.71 33.99 24 7381 7062 63474555
Laryngospasm 57.10 33.99 19 7386 3009 63478608
PCO2 increased 54.80 33.99 15 7390 1224 63480393
Lung hyperinflation 54.14 33.99 15 7390 1280 63480337
Agitation postoperative 53.62 33.99 8 7397 23 63481594
Carcinoid crisis 53.62 33.99 11 7394 255 63481362
Neuromuscular blockade 52.37 33.99 11 7394 287 63481330
Blood pH decreased 51.86 33.99 17 7388 2570 63479047
Hypoxia 51.68 33.99 48 7357 59744 63421873
Therapeutic product effect prolonged 50.33 33.99 11 7394 348 63481269
PO2 decreased 47.49 33.99 14 7391 1492 63480125
Myotonia 46.35 33.99 9 7396 156 63481461
Procedural hypertension 45.83 33.99 10 7395 314 63481303
Exposure during pregnancy 45.59 33.99 72 7333 155475 63326142
Status asthmaticus 44.93 33.99 12 7393 892 63480725
Diarrhoea 44.77 33.99 14 7391 715352 62766265
Premature delivery 44.34 33.99 33 7372 30248 63451369
Circulatory collapse 44.01 33.99 29 7376 21909 63459708
Epilepsy with myoclonic-atonic seizures 43.29 33.99 8 7397 105 63481512
Maternal exposure during delivery 43.19 33.99 13 7392 1487 63480130
Procedural complication 42.87 33.99 18 7387 5421 63476196
Hepatocellular injury 42.70 33.99 31 7374 27350 63454267
Cardio-respiratory arrest 42.18 33.99 43 7362 59916 63421701
Blood bicarbonate decreased 42.03 33.99 15 7390 2926 63478691
Mydriasis 40.11 33.99 22 7383 11934 63469683
End-tidal CO2 decreased 39.78 33.99 6 7399 19 63481598
Coma 39.64 33.99 43 7362 64321 63417296
Hypoventilation 38.37 33.99 16 7389 4738 63476879
Paralysis 38.22 33.99 20 7385 9880 63471737
Airway complication of anaesthesia 38.12 33.99 8 7397 208 63481409
Posterior reversible encephalopathy syndrome 37.42 33.99 24 7381 17321 63464296
Electrocardiogram QT prolonged 35.32 33.99 39 7366 59491 63422126
Pain 34.58 33.99 22 7383 740606 62741011
Post procedural stroke 34.43 33.99 6 7399 55 63481562
Pulmonary oedema 34.38 33.99 37 7368 54836 63426781

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 774.92 29.95 159 7121 2018 34947633
Cardiac arrest 237.07 29.95 180 7100 95979 34853672
Anaesthetic complication 235 29.95 53 7227 1067 34948584
Bradycardia 212.30 29.95 153 7127 75265 34874386
Anaphylactic reaction 207.66 29.95 111 7169 32190 34917461
Anaphylactic shock 194.41 29.95 85 7195 15856 34933795
Delayed recovery from anaesthesia 168.55 29.95 38 7242 763 34948888
Hypotension 147.04 29.95 204 7076 221445 34728206
Serotonin syndrome 140.77 29.95 73 7207 19860 34929791
Post procedural complication 139.69 29.95 61 7219 11327 34938324
Apnoea 137.99 29.95 52 7228 6612 34943039
Ventricular fibrillation 131.10 29.95 73 7207 22881 34926770
Tachycardia 130.30 29.95 121 7159 84651 34865000
Pulmonary alveolar haemorrhage 107.86 29.95 45 7235 7467 34942184
Bronchospasm 104.68 29.95 49 7231 10682 34938969
Ventricular tachycardia 103.37 29.95 66 7214 26513 34923138
Nephrogenic diabetes insipidus 101.77 29.95 28 7252 1293 34948358
Negative pressure pulmonary oedema 100.51 29.95 20 7260 213 34949438
Oxygen saturation decreased 90.75 29.95 81 7199 53737 34895914
Diabetes insipidus 83.66 29.95 29 7251 2899 34946752
Neuromuscular block prolonged 80.02 29.95 19 7261 482 34949169
Blood pressure decreased 79.91 29.95 74 7206 51441 34898210
Electrocardiogram ST segment elevation 77.28 29.95 32 7248 5206 34944445
Unwanted awareness during anaesthesia 75.29 29.95 12 7268 28 34949623
Procedural complication 72.91 29.95 29 7251 4254 34945397
Tachypnoea 72.39 29.95 46 7234 18306 34931345
Drug interaction 71.69 29.95 150 7130 225796 34723855
Hypoxic-ischaemic encephalopathy 71.33 29.95 29 7251 4503 34945148
Metabolic acidosis 68.22 29.95 63 7217 43617 34906034
Rhabdomyolysis 67.67 29.95 77 7203 68086 34881565
Laryngospasm 67.42 29.95 21 7259 1500 34948151
Recurrence of neuromuscular blockade 65.86 29.95 14 7266 211 34949440
Stress cardiomyopathy 65.09 29.95 22 7258 2037 34947614
Blood pressure measurement 63.08 29.95 13 7267 167 34949484
Haemodynamic instability 56.27 29.95 31 7249 9492 34940159
Kounis syndrome 53.38 29.95 20 7260 2498 34947153
Pulmonary oedema 51.09 29.95 56 7224 47473 34902178
Spinal cord infarction 51.05 29.95 12 7268 291 34949360
Electrocardiogram ST segment depression 50.13 29.95 19 7261 2449 34947202
Anaesthetic complication neurological 49.71 29.95 12 7268 327 34949324
Respiratory acidosis 49.04 29.95 23 7257 5027 34944624
Oculocardiac reflex 48.72 29.95 9 7271 62 34949589
Death 46.15 29.95 13 7267 398036 34551615
Extrasystoles 45.30 29.95 20 7260 3803 34945848
Sinus arrest 44.98 29.95 16 7264 1724 34947927
Diarrhoea 44.71 29.95 13 7267 389899 34559752
Seizure like phenomena 44.41 29.95 13 7267 751 34948900
Arteriospasm coronary 44.33 29.95 19 7261 3363 34946288
Pulseless electrical activity 44.05 29.95 24 7256 7187 34942464
Weight bearing difficulty 43.88 29.95 14 7266 1081 34948570
Hepatorenal failure 43.60 29.95 12 7268 554 34949097
Hypercapnia 43.24 29.95 20 7260 4235 34945416
Ventricular extrasystoles 42.18 29.95 28 7252 11980 34937671
Pneumonia 41.73 29.95 12 7268 362615 34587036
Sodium retention 41.03 29.95 8 7272 76 34949575
Muscle rigidity 40.55 29.95 26 7254 10492 34939159
Hyperkalaemia 40.01 29.95 60 7220 69329 34880322
Procedural haemorrhage 39.61 29.95 16 7264 2441 34947210
Agitation postoperative 39.33 29.95 7 7273 38 34949613
Renin increased 39.24 29.95 8 7272 97 34949554
Hyperthermia 37.97 29.95 25 7255 10552 34939099
PCO2 increased 37.75 29.95 11 7269 625 34949026
End-tidal CO2 increased 37.35 29.95 6 7274 15 34949636
Respiratory depression 36.74 29.95 29 7251 16216 34933435
Glossoptosis 36.62 29.95 8 7272 138 34949513
Suspected product quality issue 35.74 29.95 8 7272 155 34949496
Heart rate increased 35.57 29.95 46 7234 46297 34903354
Suspected product contamination 35.30 29.95 7 7273 73 34949578
Hyperventilation 34.19 29.95 15 7265 2809 34946842
Vasoplegia syndrome 33.10 29.95 13 7267 1843 34947808
Hyperaesthesia 32.77 29.95 17 7263 4613 34945038
Paroxysmal sympathetic hyperactivity 32.65 29.95 6 7274 40 34949611
Prinzmetal angina 32.65 29.95 11 7269 1008 34948643
Nodal rhythm 32.56 29.95 12 7268 1431 34948220
Acidosis 32.48 29.95 23 7257 10922 34938729
Dyskinesia 32.41 29.95 31 7249 22382 34927269
Pulse absent 31.85 29.95 18 7262 5785 34943866
Neuromuscular blockade 31.78 29.95 8 7272 260 34949391
Anaesthetic complication pulmonary 30.99 29.95 5 7275 13 34949638
Airway complication of anaesthesia 30.60 29.95 7 7273 150 34949501
Shock 30.42 29.95 31 7249 24148 34925503
Dystonia 30.36 29.95 22 7258 10823 34938828

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 879.35 27.16 180 13628 2737 79727843
Anaesthetic complication 561.95 27.16 124 13684 2735 79727845
Anaphylactic shock 399.22 27.16 170 13638 35826 79694754
Cardiac arrest 392.99 27.16 286 13522 171810 79558770
Serotonin syndrome 387.65 27.16 178 13630 44849 79685731
Hypotension 375.51 27.16 419 13389 439898 79290682
Delayed recovery from anaesthesia 347.79 27.16 76 13732 1597 79728983
Bradycardia 315.36 27.16 228 13580 135329 79595251
Bronchospasm 280.80 27.16 119 13689 24740 79705840
Anaphylactic reaction 278.80 27.16 176 13632 83567 79647013
Drug interaction 272.31 27.16 346 13462 414837 79315743
Myoglobin urine present 241.99 27.16 51 13757 896 79729684
Ventricular fibrillation 212.98 27.16 106 13702 31820 79698760
Tachycardia 196.75 27.16 195 13613 177573 79553007
Ventricular tachycardia 183.11 27.16 105 13703 41830 79688750
Oxygen saturation decreased 178.01 27.16 160 13648 128887 79601693
Unwanted awareness during anaesthesia 164.65 27.16 31 13777 295 79730285
Diabetes insipidus 163.62 27.16 53 13755 5184 79725396
Blood pressure decreased 158.63 27.16 134 13674 99332 79631248
Neuromuscular block prolonged 155.30 27.16 36 13772 994 79729586
Fatigue 129.83 27.16 8 13800 929719 78800861
Hypercapnia 128.90 27.16 51 13757 8884 79721696
Amylase increased 121.01 27.16 52 13756 11157 79719423
Toxic encephalopathy 119.99 27.16 52 13756 11388 79719192
Haemodynamic instability 119.69 27.16 59 13749 17323 79713257
Stress cardiomyopathy 117.92 27.16 51 13757 11115 79719465
Apnoea 115.61 27.16 51 13757 11653 79718927
Rhabdomyolysis 115.52 27.16 114 13694 103017 79627563
Laryngospasm 114.96 27.16 38 13770 3959 79726621
Respiratory depression 114.76 27.16 67 13741 27563 79703017
Pulmonary alveolar haemorrhage 110.20 27.16 49 13759 11408 79719172
Negative pressure pulmonary oedema 109.96 27.16 21 13787 217 79730363
Nephrogenic diabetes insipidus 106.72 27.16 31 13777 2103 79728477
Procedural complication 106.26 27.16 43 13765 7940 79722640
Torsade de pointes 105.26 27.16 56 13752 19256 79711324
Anaesthetic complication neurological 105.05 27.16 24 13784 620 79729960
Hepatorenal failure 102.81 27.16 27 13781 1258 79729322
Respiratory acidosis 98.50 27.16 45 13763 11155 79719425
Suspected product quality issue 98.03 27.16 20 13788 297 79730283
Recurrence of neuromuscular blockade 97.91 27.16 20 13788 299 79730281
Dystonia 94.48 27.16 54 13754 21345 79709235
Blood potassium increased 93.45 27.16 60 13748 29215 79701365
Troponin increased 91.53 27.16 51 13757 19204 79711376
Post procedural complication 86.52 27.16 53 13755 23776 79706804
Diarrhoea 82.85 27.16 25 13783 880464 78850116
Arthralgia 82.50 27.16 4 13804 571799 79158781
Procedural hypotension 82.07 27.16 25 13783 1998 79728582
Blood creatine phosphokinase increased 81.39 27.16 77 13731 66013 79664567
Neuromuscular blockade 80.73 27.16 19 13789 561 79730019
Airway peak pressure increased 79.09 27.16 17 13791 329 79730251
Extrasystoles 78.70 27.16 34 13774 7385 79723195
Pulmonary oedema 78.05 27.16 86 13722 88168 79642412
Vasoplegia syndrome 75.18 27.16 27 13781 3603 79726977
Electrocardiogram ST segment elevation 74.66 27.16 34 13774 8363 79722217
Cyanosis 73.98 27.16 49 13759 25133 79705447
Hypoxic-ischaemic encephalopathy 73.77 27.16 33 13775 7787 79722793
PCO2 increased 71.50 27.16 22 13786 1818 79728762
Blood lactate dehydrogenase increased 71.21 27.16 57 13751 39113 79691467
Ventricular extrasystoles 69.43 27.16 43 13765 19661 79710919
Hypoxia 68.72 27.16 87 13721 103156 79627424
Suspected product contamination 66.05 27.16 12 13796 92 79730488
Fall 65.53 27.16 5 13803 487624 79242956
Tachypnoea 65.52 27.16 50 13758 32013 79698567
Pneumonia 65.27 27.16 17 13791 660229 79070351
Metabolic acidosis 63.77 27.16 75 13733 82454 79648126
Kounis syndrome 63.71 27.16 25 13783 4257 79726323
Carcinoid crisis 61.75 27.16 15 13793 508 79730072
Airway complication of anaesthesia 59.72 27.16 14 13794 406 79730174
End-tidal CO2 increased 59.07 27.16 9 13799 18 79730562
Procedural hypertension 57.50 27.16 13 13795 320 79730260
Phrenic nerve paralysis 57.19 27.16 13 13795 328 79730252
Arteriospasm coronary 55.97 27.16 26 13782 6690 79723890
Endotracheal intubation complication 55.02 27.16 15 13793 807 79729773
Muscle rigidity 54.35 27.16 37 13771 19845 79710735
Hypoventilation 54.16 27.16 26 13782 7198 79723382
Blood pressure measurement 53.52 27.16 13 13795 440 79730140
Tracheal deviation 53.50 27.16 11 13797 170 79730410
Pulseless electrical activity 52.69 27.16 32 13776 14128 79716452
Circulatory collapse 52.40 27.16 47 13761 37621 79692959
Headache 52.27 27.16 24 13784 653748 79076832
Procedural haemorrhage 51.34 27.16 22 13786 4684 79725896
Blood pH decreased 51.32 27.16 22 13786 4689 79725891
Postoperative delirium 51.09 27.16 12 13796 351 79730229
Oculocardiac reflex 50.38 27.16 9 13799 62 79730518
PO2 decreased 50.15 27.16 19 13789 2944 79727636
Death 49.81 27.16 18 13790 566496 79164084
Weight decreased 49.57 27.16 3 13805 355195 79375385
Spinal cord infarction 49.41 27.16 13 13795 610 79729970
Agitation postoperative 48.87 27.16 9 13799 75 79730505
Pulse absent 48.66 27.16 27 13781 10076 79720504
Electrocardiogram ST segment depression 47.34 27.16 21 13787 4857 79725723
Therapeutic product effect prolonged 45.53 27.16 12 13796 567 79730013
Blood lactic acid increased 45.37 27.16 28 13780 12716 79717864
Acidosis 45.24 27.16 33 13775 19729 79710851
Pain 44.74 27.16 34 13774 703768 79026812
Cardio-respiratory arrest 43.62 27.16 72 13736 108438 79622142
Hyperthermia 43.30 27.16 31 13777 18006 79712574
Pain in extremity 43.12 27.16 6 13802 364532 79366048
Cardiac output decreased 43.12 27.16 15 13793 1823 79728757
Sinus arrest 43.06 27.16 18 13790 3604 79726976
Lung hyperinflation 42.95 27.16 15 13793 1844 79728736
Status asthmaticus 42.89 27.16 13 13795 1021 79729559
Anaesthetic complication cardiac 42.89 27.16 8 13800 72 79730508
Alanine aminotransferase increased 41.73 27.16 89 13719 162481 79568099
Mydriasis 41.61 27.16 30 13778 17613 79712967
Malaise 40.67 27.16 17 13791 489852 79240728
Epilepsy with myoclonic-atonic seizures 39.92 27.16 8 13800 108 79730472
Decreased appetite 39.65 27.16 6 13802 342412 79388168
Accelerated idioventricular rhythm 39.56 27.16 9 13799 228 79730352
Myotonia 39.33 27.16 9 13799 234 79730346
Seizure like phenomena 39.09 27.16 14 13794 1853 79728727
Trigemino-cardiac reflex 38.42 27.16 9 13799 260 79730320
Hyperkalaemia 38.27 27.16 70 13738 114328 79616252
Shock 37.71 27.16 42 13766 43506 79687074
Atrioventricular block second degree 36.48 27.16 20 13788 7292 79723288
Maternal exposure during delivery 35.53 27.16 12 13796 1334 79729246
Peripheral swelling 35.52 27.16 3 13805 269614 79460966
Dizziness 35.29 27.16 24 13784 526417 79204163
Dyskinesia 35.08 27.16 41 13767 44732 79685848
Paralysis 34.78 27.16 24 13784 13153 79717427
Drug intolerance 34.63 27.16 3 13805 264116 79466464
Long QT syndrome 34.52 27.16 18 13790 5937 79724643
Device issue 34.14 27.16 32 13776 27076 79703504
Post procedural stroke 34.12 27.16 7 13801 107 79730473
Blood bicarbonate decreased 33.89 27.16 17 13791 5174 79725406
Atrioventricular block 33.40 27.16 24 13784 14017 79716563
Abdominal pain 33.16 27.16 13 13795 389556 79341024
Constipation 32.67 27.16 5 13803 283045 79447535
Generalised tonic-clonic seizure 32.40 27.16 39 13769 43871 79686709
Chemical peritonitis 32.32 27.16 8 13800 293 79730287
Weight bearing difficulty 31.69 27.16 14 13794 3207 79727373
Upper airway obstruction 31.00 27.16 11 13797 1417 79729163
Sinus tachycardia 30.94 27.16 35 13773 36873 79693707
Heart rate increased 30.86 27.16 66 13742 120658 79609922
Anaphylactoid reaction 30.32 27.16 16 13792 5406 79725174
Anaesthetic complication pulmonary 30.29 27.16 6 13802 76 79730504
Hyperdynamic left ventricle 30.01 27.16 8 13800 395 79730185
Hyperventilation 29.77 27.16 18 13790 7881 79722699
Product dose omission issue 29.43 27.16 4 13804 247533 79483047
Glossoptosis 29.20 27.16 7 13801 224 79730356
Completed suicide 29.15 27.16 4 13804 245763 79484817
Neutropenia 29.15 27.16 7 13801 287703 79442877
Prinzmetal angina 29.00 27.16 11 13797 1709 79728871
Acute pulmonary oedema 28.64 27.16 22 13786 14208 79716372
Light anaesthesia 28.41 27.16 4 13804 3 79730577
Hepatocellular injury 28.36 27.16 38 13770 47555 79683025
Change in seizure presentation 27.96 27.16 8 13800 514 79730066
Oedema peripheral 27.90 27.16 5 13803 252283 79478297
Atrioventricular block complete 27.71 27.16 23 13785 16587 79713993
Polyuria 27.60 27.16 22 13786 14992 79715588
End-tidal CO2 decreased 27.56 27.16 5 13803 38 79730542
Electroencephalogram abnormal 27.48 27.16 15 13793 5419 79725161
Electrocardiogram QT prolonged 27.35 27.16 53 13755 90333 79640247
Agitation 27.21 27.16 56 13752 99659 79630921
Urinary tract infection 27.18 27.16 7 13801 274505 79456075

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AB08 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006401 Hematologic Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
CHEBI has role CHEBI:35488 central nervous system depressants
CHEBI has role CHEBI:38870 inhalation anesthetics
CHEBI has role CHEBI:50427 platelet aggregation inhibitors
FDA EPC N0000175681 General Anesthetic
FDA PE N0000175975 General Anesthesia

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Proteinuria contraindication 29738008 DOID:576
Low blood pressure contraindication 45007003
Glycosuria contraindication 45154002
Benign intracranial hypertension contraindication 68267002 DOID:11459
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Kidney disease contraindication 90708001 DOID:557
Seizure disorder contraindication 128613002
Disease of liver contraindication 235856003 DOID:409
Malignant hyperthermia contraindication 405501007




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Induction and maintenance of general anesthesia Indication

🐶 Veterinary products

ProductApplicantIngredients
SevoFlo Zoetis Inc. 1
Petrem Piramal Critical Care Inc. 1
Sevoflurane Dechra Veterinary Products LLC 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycine receptor subunit alpha-1 Ion channel POSITIVE MODULATOR DRUGBANK CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4020924 VUID
N0000148409 NUI
D00547 KEGG_DRUG
4020924 VANDF
C0074414 UMLSCUI
CHEBI:9130 CHEBI
CHEMBL1200694 ChEMBL_ID
DB01236 DRUGBANK_ID
D000077149 MESH_DESCRIPTOR_UI
5206 PUBCHEM_CID
3028 INN_ID
7296 IUPHAR_LIGAND_ID
38LVP0K73A UNII
1245040 RXNORM
7414 MMSL
81183 MMSL
d03845 MMSL
005015 NDDF
108395008 SNOMEDCT_US
386842005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ultane HUMAN PRESCRIPTION DRUG LABEL 1 0074-4456 LIQUID 250 mL RESPIRATORY (INHALATION) NDA 32 sections
Ultane HUMAN PRESCRIPTION DRUG LABEL 1 0074-4456 LIQUID 250 mL RESPIRATORY (INHALATION) NDA 32 sections
Ultane HUMAN PRESCRIPTION DRUG LABEL 1 0074-4456 LIQUID 250 mL RESPIRATORY (INHALATION) NDA 32 sections
Ultane HUMAN PRESCRIPTION DRUG LABEL 1 0074-4456 LIQUID 250 mL RESPIRATORY (INHALATION) NDA 32 sections
Ultane HUMAN PRESCRIPTION DRUG LABEL 1 0074-4456 LIQUID 250 mL RESPIRATORY (INHALATION) NDA 32 sections
Ultane HUMAN PRESCRIPTION DRUG LABEL 1 0074-4456 LIQUID 250 mL RESPIRATORY (INHALATION) NDA 32 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 0781-6160 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 20 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 0781-6160 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 20 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 0781-6160 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 20 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 10019-651 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 10019-651 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 10019-651 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
SEVOFLURANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-653 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
SEVOFLURANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-653 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
SEVOFLURANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-653 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 10019-655 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 10019-655 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
SEVOFLURANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-657 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
SEVOFLURANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-657 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 27 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 12164-005 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 26 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 12164-005 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 26 sections
Sojourn HUMAN PRESCRIPTION DRUG LABEL 1 66794-012 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 23 sections
Sojourn HUMAN PRESCRIPTION DRUG LABEL 1 66794-012 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 23 sections
Sojourn HUMAN PRESCRIPTION DRUG LABEL 1 66794-012 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 23 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-015 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 23 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-015 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 23 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-015 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 23 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-022 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 15 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-022 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 15 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-022 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 15 sections