sevoflurane Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 2439 28523-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sevoflurane
  • sevoflo
  • sevofluran
  • sevofrane
  • sevorane
A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
  • Molecular weight: 200.06
  • Formula: C4H3F7O
  • CLOGP: 1.45
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -2.13
  • ROTB: 4

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
June 7, 1995 FDA ABBVIE

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaesthetic complication neurological 1351.59 84.66 169 2567 65 4636191
Hyperthermia malignant 932.64 84.66 139 2597 555 4635701
Anaesthetic complication 833.07 84.66 130 2606 746 4635510
Unwanted awareness during anaesthesia 793.50 84.66 101 2635 58 4636198
Cardiac arrest 433.39 84.66 149 2587 33858 4602398
Hypotension 413.86 84.66 173 2563 67227 4569029
Foetal exposure during pregnancy 405.10 84.66 129 2607 23040 4613216
Post procedural complication 399.72 84.66 95 2641 5676 4630580
Low birth weight baby 365.58 84.66 77 2659 2633 4633623
Delayed recovery from anaesthesia 344.53 84.66 54 2682 315 4635941
Bradycardia 342.73 84.66 113 2623 22456 4613800
Tachycardia 256.05 84.66 99 2637 31046 4605210
Ventricular fibrillation 248.78 84.66 64 2672 5273 4630983
Anaphylactic shock 246.97 84.66 69 2667 7788 4628468
Hyperthermia 234.86 84.66 56 2680 3368 4632888
Oxygen saturation decreased 231.31 84.66 75 2661 14046 4622210
Ventricular tachycardia 210.21 84.66 60 2676 7304 4628952
Blood pressure decreased 202.40 84.66 72 2664 17828 4618428
Rhabdomyolysis 188.77 84.66 70 2666 19488 4616768
Bronchospasm 174.98 84.66 49 2687 5557 4630699
Atrial fibrillation 173.35 84.66 75 2661 31140 4605116
Hepatorenal failure 170.29 84.66 29 2707 299 4635957
Product tampering 149.97 84.66 24 2712 162 4636094
Suspected product quality issue 145.86 84.66 21 2715 60 4636196
Laryngospasm 137.68 84.66 30 2706 1197 4635059
Electroencephalogram abnormal 130.11 84.66 30 2706 1551 4634705
Anaphylactic reaction 129.49 84.66 52 2684 17858 4618398
Hypercapnia 127.66 84.66 28 2708 1152 4635104
Hypoxia 126.59 84.66 47 2689 13074 4623182
Product odour abnormal 121.14 84.66 25 2711 765 4635491
PCO2 increased 120.09 84.66 22 2714 354 4635902
Electrocardiogram QT prolonged 119.59 84.66 47 2689 15248 4621008
Device issue 115.19 84.66 40 2696 9177 4627079
Cyanosis 113.81 84.66 36 2700 6186 4630070
Haemodynamic instability 108.96 84.66 29 2707 2710 4633546
Electrocardiogram ST segment depression 105.94 84.66 24 2712 1145 4635111
Torsade de pointes 102.78 84.66 30 2706 3931 4632325
Acute kidney injury 98.89 84.66 68 2668 70363 4565893
Respiratory acidosis 98.14 84.66 24 2712 1597 4634659
Ventricular extrasystoles 97.20 84.66 29 2707 4097 4632159
Hypoxic-ischaemic encephalopathy 96.06 84.66 24 2712 1745 4634511
Seizure 91.20 84.66 57 2679 50180 4586076
Apnoea 90.79 84.66 26 2710 3182 4633074
Erythema 90.05 84.66 53 2683 41887 4594369
Carcinoid crisis 85.57 84.66 13 2723 59 4636197
Septic shock 85.46 84.66 38 2698 16728 4619528
Diabetes insipidus 84.83 84.66 19 2717 860 4635396

Pharmacologic Action:

SourceCodeDescription
ATC N01AB08 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
FDA PE N0000175975 General Anesthesia
FDA EPC N0000175681 General Anesthetic
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
CHEBI has role CHEBI:38870 inhalation anaesthetic
CHEBI has role CHEBI:50427 platelet aggregation inhibitor
CHEBI has role CHEBI:35488 central nervous system depressant
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006401 Hematologic Agents
MeSH PA D010975 Platelet Aggregation Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Proteinuria contraindication 29738008 DOID:576
Low blood pressure contraindication 45007003
Glycosuria contraindication 45154002
Benign intracranial hypertension contraindication 68267002 DOID:11459
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Kidney disease contraindication 90708001 DOID:557
Seizure disorder contraindication 128613002
Disease of liver contraindication 235856003 DOID:409
Malignant hyperthermia contraindication 405501007

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycine receptor subunit alpha-1 Ion channel POSITIVE MODULATOR DRUGBANK CHEMBL
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL

External reference:

IDSource
D000077149 MESH_DESCRIPTOR_UI
4020924 VUID
N0000148409 NUI
C0074414 UMLSCUI
D00547 KEGG_DRUG
38LVP0K73A UNII
3028 INN_ID
108395008 SNOMEDCT_US
4020924 VANDF
81183 MMSL
386842005 SNOMEDCT_US
d03845 MMSL
7414 MMSL
36453 RXNORM
005015 NDDF
5206 PUBCHEM_CID
CHEBI:9130 CHEBI
CHEMBL1200694 ChEMBL_ID
DB01236 DRUGBANK_ID
7296 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ultane HUMAN PRESCRIPTION DRUG LABEL 1 0074-4456 LIQUID 250 mL RESPIRATORY (INHALATION) NDA 13 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 0781-6160 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 13 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 10019-651 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 12 sections
SEVOFLURANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-653 LIQUID 250 mL RESPIRATORY (INHALATION) ANDA 13 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 12164-005 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Sojourn HUMAN PRESCRIPTION DRUG LABEL 1 66794-012 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Sevoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-015 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Sevoflurane Bostonbio HUMAN PRESCRIPTION DRUG LABEL 1 72163-005 INHALANT 1 mL RESPIRATORY (INHALATION) ANDA 2 sections