sevoflurane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
halogenated compounds used as general inhalation anaesthetics	2439	28523-86-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sevoflurane sevoflo sevofluran sevofrane sevorane	A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION. Molecular weight: 200.06 Formula: C4H3F7O CLOGP: 1.83 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: 9.23 ALOGS: -2.13 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sevoflurane
sevoflo
sevofluran
sevofrane
sevorane

A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.

Molecular weight: 200.06
Formula: C4H3F7O
CLOGP: 1.83
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA: 9.23
ALOGS: -2.13
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
June 7, 1995	FDA	ABBVIE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Serotonin syndrome	321.07	33.99	122	7283	28560	63453057
Myoglobin urine present	291.70	33.99	54	7351	718	63480899
Hypotension	288.12	33.99	244	7161	272360	63209257
Drug interaction	266.67	33.99	217	7188	228914	63252703
Delayed recovery from anaesthesia	228.71	33.99	44	7361	727	63480890
Hyperthermia malignant	225.26	33.99	44	7361	790	63480827
Anaphylactic shock	223.51	33.99	89	7316	23544	63458073
Unwanted awareness during anaesthesia	202.73	33.99	35	7370	303	63481314
Bronchospasm	202.26	33.99	76	7329	17204	63464413
Toxic encephalopathy	185.22	33.99	56	7349	6523	63475094
Anaesthetic complication	182.54	33.99	43	7362	1917	63479700
Cardiac arrest	180.63	33.99	120	7285	92425	63389192
Amylase increased	178.59	33.99	54	7351	6291	63475326
Bradycardia	162.60	33.99	103	7302	73124	63408493
Troponin increased	150.00	33.99	53	7352	10068	63471549
Blood potassium increased	126.00	33.99	55	7350	18254	63463363
Blood lactate dehydrogenase increased	119.82	33.99	57	7348	23059	63458558
Apnoea	115.03	33.99	41	7364	7981	63473636
Blood creatine phosphokinase increased	113.42	33.99	60	7345	30370	63451247
Hypercapnia	110.16	33.99	36	7369	5395	63476222
Oxygen saturation decreased	106.96	33.99	86	7319	88499	63393118
Tachycardia	102.63	33.99	95	7310	118061	63363556
Blood pressure decreased	102.46	33.99	74	7331	64948	63416669
Diabetes insipidus	94.30	33.99	27	7378	2598	63479019
Torsade de pointes	91.50	33.99	40	7365	13311	63468306
Neuromuscular block prolonged	89.50	33.99	19	7386	523	63481094
Breast cancer recurrent	88.95	33.99	29	7376	4312	63477305
Ventricular tachycardia	87.73	33.99	44	7361	19935	63461682
Anaphylactic reaction	85.82	33.99	67	7338	66033	63415584
Haemodynamic instability	84.68	33.99	34	7371	9156	63472461
Post procedural complication	79.10	33.99	39	7366	17035	63464582
Fatigue	78.35	33.99	7	7398	888021	62593596
Ventricular fibrillation	76.30	33.99	34	7371	11833	63469784
Rhabdomyolysis	76.09	33.99	53	7352	43898	63437719
Respiratory depression	74.67	33.99	35	7370	13680	63467937
Stress cardiomyopathy	73.60	33.99	31	7374	9419	63472198
Airway peak pressure increased	70.17	33.99	14	7391	281	63481336
Dystonia	68.31	33.99	33	7372	13786	63467831
Suspected product quality issue	67.71	33.99	13	7392	212	63481405
Alanine aminotransferase increased	66.95	33.99	71	7334	103699	63377918
Procedural hypotension	64.89	33.99	17	7388	1173	63480444
Hepatorenal failure	63.43	33.99	15	7390	679	63480938
Phrenic nerve paralysis	63.19	33.99	12	7393	184	63481433
Recurrence of neuromuscular blockade	60.36	33.99	11	7394	133	63481484
Anaesthetic complication neurological	59.63	33.99	12	7393	252	63481365
Cyanosis	59.16	33.99	32	7373	16903	63464714
Tracheal deviation	59.06	33.99	11	7394	151	63481466
Respiratory acidosis	58.96	33.99	24	7381	6691	63474926
Vasoplegia syndrome	58.90	33.99	17	7388	1682	63479935
Postoperative delirium	57.86	33.99	10	7395	87	63481530
Blood lactic acid increased	57.71	33.99	24	7381	7062	63474555
Laryngospasm	57.10	33.99	19	7386	3009	63478608
PCO2 increased	54.80	33.99	15	7390	1224	63480393
Lung hyperinflation	54.14	33.99	15	7390	1280	63480337
Agitation postoperative	53.62	33.99	8	7397	23	63481594
Carcinoid crisis	53.62	33.99	11	7394	255	63481362
Neuromuscular blockade	52.37	33.99	11	7394	287	63481330
Blood pH decreased	51.86	33.99	17	7388	2570	63479047
Hypoxia	51.68	33.99	48	7357	59744	63421873
Therapeutic product effect prolonged	50.33	33.99	11	7394	348	63481269
PO2 decreased	47.49	33.99	14	7391	1492	63480125
Myotonia	46.35	33.99	9	7396	156	63481461
Procedural hypertension	45.83	33.99	10	7395	314	63481303
Exposure during pregnancy	45.59	33.99	72	7333	155475	63326142
Status asthmaticus	44.93	33.99	12	7393	892	63480725
Diarrhoea	44.77	33.99	14	7391	715352	62766265
Premature delivery	44.34	33.99	33	7372	30248	63451369
Circulatory collapse	44.01	33.99	29	7376	21909	63459708
Epilepsy with myoclonic-atonic seizures	43.29	33.99	8	7397	105	63481512
Maternal exposure during delivery	43.19	33.99	13	7392	1487	63480130
Procedural complication	42.87	33.99	18	7387	5421	63476196
Hepatocellular injury	42.70	33.99	31	7374	27350	63454267
Cardio-respiratory arrest	42.18	33.99	43	7362	59916	63421701
Blood bicarbonate decreased	42.03	33.99	15	7390	2926	63478691
Mydriasis	40.11	33.99	22	7383	11934	63469683
End-tidal CO2 decreased	39.78	33.99	6	7399	19	63481598
Coma	39.64	33.99	43	7362	64321	63417296
Hypoventilation	38.37	33.99	16	7389	4738	63476879
Paralysis	38.22	33.99	20	7385	9880	63471737
Airway complication of anaesthesia	38.12	33.99	8	7397	208	63481409
Posterior reversible encephalopathy syndrome	37.42	33.99	24	7381	17321	63464296
Electrocardiogram QT prolonged	35.32	33.99	39	7366	59491	63422126
Pain	34.58	33.99	22	7383	740606	62741011
Post procedural stroke	34.43	33.99	6	7399	55	63481562
Pulmonary oedema	34.38	33.99	37	7368	54836	63426781

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperthermia malignant	774.92	29.95	159	7121	2018	34947633
Cardiac arrest	237.07	29.95	180	7100	95979	34853672
Anaesthetic complication	235	29.95	53	7227	1067	34948584
Bradycardia	212.30	29.95	153	7127	75265	34874386
Anaphylactic reaction	207.66	29.95	111	7169	32190	34917461
Anaphylactic shock	194.41	29.95	85	7195	15856	34933795
Delayed recovery from anaesthesia	168.55	29.95	38	7242	763	34948888
Hypotension	147.04	29.95	204	7076	221445	34728206
Serotonin syndrome	140.77	29.95	73	7207	19860	34929791
Post procedural complication	139.69	29.95	61	7219	11327	34938324
Apnoea	137.99	29.95	52	7228	6612	34943039
Ventricular fibrillation	131.10	29.95	73	7207	22881	34926770
Tachycardia	130.30	29.95	121	7159	84651	34865000
Pulmonary alveolar haemorrhage	107.86	29.95	45	7235	7467	34942184
Bronchospasm	104.68	29.95	49	7231	10682	34938969
Ventricular tachycardia	103.37	29.95	66	7214	26513	34923138
Nephrogenic diabetes insipidus	101.77	29.95	28	7252	1293	34948358
Negative pressure pulmonary oedema	100.51	29.95	20	7260	213	34949438
Oxygen saturation decreased	90.75	29.95	81	7199	53737	34895914
Diabetes insipidus	83.66	29.95	29	7251	2899	34946752
Neuromuscular block prolonged	80.02	29.95	19	7261	482	34949169
Blood pressure decreased	79.91	29.95	74	7206	51441	34898210
Electrocardiogram ST segment elevation	77.28	29.95	32	7248	5206	34944445
Unwanted awareness during anaesthesia	75.29	29.95	12	7268	28	34949623
Procedural complication	72.91	29.95	29	7251	4254	34945397
Tachypnoea	72.39	29.95	46	7234	18306	34931345
Drug interaction	71.69	29.95	150	7130	225796	34723855
Hypoxic-ischaemic encephalopathy	71.33	29.95	29	7251	4503	34945148
Metabolic acidosis	68.22	29.95	63	7217	43617	34906034
Rhabdomyolysis	67.67	29.95	77	7203	68086	34881565
Laryngospasm	67.42	29.95	21	7259	1500	34948151
Recurrence of neuromuscular blockade	65.86	29.95	14	7266	211	34949440
Stress cardiomyopathy	65.09	29.95	22	7258	2037	34947614
Blood pressure measurement	63.08	29.95	13	7267	167	34949484
Haemodynamic instability	56.27	29.95	31	7249	9492	34940159
Kounis syndrome	53.38	29.95	20	7260	2498	34947153
Pulmonary oedema	51.09	29.95	56	7224	47473	34902178
Spinal cord infarction	51.05	29.95	12	7268	291	34949360
Electrocardiogram ST segment depression	50.13	29.95	19	7261	2449	34947202
Anaesthetic complication neurological	49.71	29.95	12	7268	327	34949324
Respiratory acidosis	49.04	29.95	23	7257	5027	34944624
Oculocardiac reflex	48.72	29.95	9	7271	62	34949589
Death	46.15	29.95	13	7267	398036	34551615
Extrasystoles	45.30	29.95	20	7260	3803	34945848
Sinus arrest	44.98	29.95	16	7264	1724	34947927
Diarrhoea	44.71	29.95	13	7267	389899	34559752
Seizure like phenomena	44.41	29.95	13	7267	751	34948900
Arteriospasm coronary	44.33	29.95	19	7261	3363	34946288
Pulseless electrical activity	44.05	29.95	24	7256	7187	34942464
Weight bearing difficulty	43.88	29.95	14	7266	1081	34948570
Hepatorenal failure	43.60	29.95	12	7268	554	34949097
Hypercapnia	43.24	29.95	20	7260	4235	34945416
Ventricular extrasystoles	42.18	29.95	28	7252	11980	34937671
Pneumonia	41.73	29.95	12	7268	362615	34587036
Sodium retention	41.03	29.95	8	7272	76	34949575
Muscle rigidity	40.55	29.95	26	7254	10492	34939159
Hyperkalaemia	40.01	29.95	60	7220	69329	34880322
Procedural haemorrhage	39.61	29.95	16	7264	2441	34947210
Agitation postoperative	39.33	29.95	7	7273	38	34949613
Renin increased	39.24	29.95	8	7272	97	34949554
Hyperthermia	37.97	29.95	25	7255	10552	34939099
PCO2 increased	37.75	29.95	11	7269	625	34949026
End-tidal CO2 increased	37.35	29.95	6	7274	15	34949636
Respiratory depression	36.74	29.95	29	7251	16216	34933435
Glossoptosis	36.62	29.95	8	7272	138	34949513
Suspected product quality issue	35.74	29.95	8	7272	155	34949496
Heart rate increased	35.57	29.95	46	7234	46297	34903354
Suspected product contamination	35.30	29.95	7	7273	73	34949578
Hyperventilation	34.19	29.95	15	7265	2809	34946842
Vasoplegia syndrome	33.10	29.95	13	7267	1843	34947808
Hyperaesthesia	32.77	29.95	17	7263	4613	34945038
Paroxysmal sympathetic hyperactivity	32.65	29.95	6	7274	40	34949611
Prinzmetal angina	32.65	29.95	11	7269	1008	34948643
Nodal rhythm	32.56	29.95	12	7268	1431	34948220
Acidosis	32.48	29.95	23	7257	10922	34938729
Dyskinesia	32.41	29.95	31	7249	22382	34927269
Pulse absent	31.85	29.95	18	7262	5785	34943866
Neuromuscular blockade	31.78	29.95	8	7272	260	34949391
Anaesthetic complication pulmonary	30.99	29.95	5	7275	13	34949638
Airway complication of anaesthesia	30.60	29.95	7	7273	150	34949501
Shock	30.42	29.95	31	7249	24148	34925503
Dystonia	30.36	29.95	22	7258	10823	34938828

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperthermia malignant	879.35	27.16	180	13628	2737	79727843
Anaesthetic complication	561.95	27.16	124	13684	2735	79727845
Anaphylactic shock	399.22	27.16	170	13638	35826	79694754
Cardiac arrest	392.99	27.16	286	13522	171810	79558770
Serotonin syndrome	387.65	27.16	178	13630	44849	79685731
Hypotension	375.51	27.16	419	13389	439898	79290682
Delayed recovery from anaesthesia	347.79	27.16	76	13732	1597	79728983
Bradycardia	315.36	27.16	228	13580	135329	79595251
Bronchospasm	280.80	27.16	119	13689	24740	79705840
Anaphylactic reaction	278.80	27.16	176	13632	83567	79647013
Drug interaction	272.31	27.16	346	13462	414837	79315743
Myoglobin urine present	241.99	27.16	51	13757	896	79729684
Ventricular fibrillation	212.98	27.16	106	13702	31820	79698760
Tachycardia	196.75	27.16	195	13613	177573	79553007
Ventricular tachycardia	183.11	27.16	105	13703	41830	79688750
Oxygen saturation decreased	178.01	27.16	160	13648	128887	79601693
Unwanted awareness during anaesthesia	164.65	27.16	31	13777	295	79730285
Diabetes insipidus	163.62	27.16	53	13755	5184	79725396
Blood pressure decreased	158.63	27.16	134	13674	99332	79631248
Neuromuscular block prolonged	155.30	27.16	36	13772	994	79729586
Fatigue	129.83	27.16	8	13800	929719	78800861
Hypercapnia	128.90	27.16	51	13757	8884	79721696
Amylase increased	121.01	27.16	52	13756	11157	79719423
Toxic encephalopathy	119.99	27.16	52	13756	11388	79719192
Haemodynamic instability	119.69	27.16	59	13749	17323	79713257
Stress cardiomyopathy	117.92	27.16	51	13757	11115	79719465
Apnoea	115.61	27.16	51	13757	11653	79718927
Rhabdomyolysis	115.52	27.16	114	13694	103017	79627563
Laryngospasm	114.96	27.16	38	13770	3959	79726621
Respiratory depression	114.76	27.16	67	13741	27563	79703017
Pulmonary alveolar haemorrhage	110.20	27.16	49	13759	11408	79719172
Negative pressure pulmonary oedema	109.96	27.16	21	13787	217	79730363
Nephrogenic diabetes insipidus	106.72	27.16	31	13777	2103	79728477
Procedural complication	106.26	27.16	43	13765	7940	79722640
Torsade de pointes	105.26	27.16	56	13752	19256	79711324
Anaesthetic complication neurological	105.05	27.16	24	13784	620	79729960
Hepatorenal failure	102.81	27.16	27	13781	1258	79729322
Respiratory acidosis	98.50	27.16	45	13763	11155	79719425
Suspected product quality issue	98.03	27.16	20	13788	297	79730283
Recurrence of neuromuscular blockade	97.91	27.16	20	13788	299	79730281
Dystonia	94.48	27.16	54	13754	21345	79709235
Blood potassium increased	93.45	27.16	60	13748	29215	79701365
Troponin increased	91.53	27.16	51	13757	19204	79711376
Post procedural complication	86.52	27.16	53	13755	23776	79706804
Diarrhoea	82.85	27.16	25	13783	880464	78850116
Arthralgia	82.50	27.16	4	13804	571799	79158781
Procedural hypotension	82.07	27.16	25	13783	1998	79728582
Blood creatine phosphokinase increased	81.39	27.16	77	13731	66013	79664567
Neuromuscular blockade	80.73	27.16	19	13789	561	79730019
Airway peak pressure increased	79.09	27.16	17	13791	329	79730251
Extrasystoles	78.70	27.16	34	13774	7385	79723195
Pulmonary oedema	78.05	27.16	86	13722	88168	79642412
Vasoplegia syndrome	75.18	27.16	27	13781	3603	79726977
Electrocardiogram ST segment elevation	74.66	27.16	34	13774	8363	79722217
Cyanosis	73.98	27.16	49	13759	25133	79705447
Hypoxic-ischaemic encephalopathy	73.77	27.16	33	13775	7787	79722793
PCO2 increased	71.50	27.16	22	13786	1818	79728762
Blood lactate dehydrogenase increased	71.21	27.16	57	13751	39113	79691467
Ventricular extrasystoles	69.43	27.16	43	13765	19661	79710919
Hypoxia	68.72	27.16	87	13721	103156	79627424
Suspected product contamination	66.05	27.16	12	13796	92	79730488
Fall	65.53	27.16	5	13803	487624	79242956
Tachypnoea	65.52	27.16	50	13758	32013	79698567
Pneumonia	65.27	27.16	17	13791	660229	79070351
Metabolic acidosis	63.77	27.16	75	13733	82454	79648126
Kounis syndrome	63.71	27.16	25	13783	4257	79726323
Carcinoid crisis	61.75	27.16	15	13793	508	79730072
Airway complication of anaesthesia	59.72	27.16	14	13794	406	79730174
End-tidal CO2 increased	59.07	27.16	9	13799	18	79730562
Procedural hypertension	57.50	27.16	13	13795	320	79730260
Phrenic nerve paralysis	57.19	27.16	13	13795	328	79730252
Arteriospasm coronary	55.97	27.16	26	13782	6690	79723890
Endotracheal intubation complication	55.02	27.16	15	13793	807	79729773
Muscle rigidity	54.35	27.16	37	13771	19845	79710735
Hypoventilation	54.16	27.16	26	13782	7198	79723382
Blood pressure measurement	53.52	27.16	13	13795	440	79730140
Tracheal deviation	53.50	27.16	11	13797	170	79730410
Pulseless electrical activity	52.69	27.16	32	13776	14128	79716452
Circulatory collapse	52.40	27.16	47	13761	37621	79692959
Headache	52.27	27.16	24	13784	653748	79076832
Procedural haemorrhage	51.34	27.16	22	13786	4684	79725896
Blood pH decreased	51.32	27.16	22	13786	4689	79725891
Postoperative delirium	51.09	27.16	12	13796	351	79730229
Oculocardiac reflex	50.38	27.16	9	13799	62	79730518
PO2 decreased	50.15	27.16	19	13789	2944	79727636
Death	49.81	27.16	18	13790	566496	79164084
Weight decreased	49.57	27.16	3	13805	355195	79375385
Spinal cord infarction	49.41	27.16	13	13795	610	79729970
Agitation postoperative	48.87	27.16	9	13799	75	79730505
Pulse absent	48.66	27.16	27	13781	10076	79720504
Electrocardiogram ST segment depression	47.34	27.16	21	13787	4857	79725723
Therapeutic product effect prolonged	45.53	27.16	12	13796	567	79730013
Blood lactic acid increased	45.37	27.16	28	13780	12716	79717864
Acidosis	45.24	27.16	33	13775	19729	79710851
Pain	44.74	27.16	34	13774	703768	79026812
Cardio-respiratory arrest	43.62	27.16	72	13736	108438	79622142
Hyperthermia	43.30	27.16	31	13777	18006	79712574
Pain in extremity	43.12	27.16	6	13802	364532	79366048
Cardiac output decreased	43.12	27.16	15	13793	1823	79728757
Sinus arrest	43.06	27.16	18	13790	3604	79726976
Lung hyperinflation	42.95	27.16	15	13793	1844	79728736
Status asthmaticus	42.89	27.16	13	13795	1021	79729559
Anaesthetic complication cardiac	42.89	27.16	8	13800	72	79730508
Alanine aminotransferase increased	41.73	27.16	89	13719	162481	79568099
Mydriasis	41.61	27.16	30	13778	17613	79712967
Malaise	40.67	27.16	17	13791	489852	79240728
Epilepsy with myoclonic-atonic seizures	39.92	27.16	8	13800	108	79730472
Decreased appetite	39.65	27.16	6	13802	342412	79388168
Accelerated idioventricular rhythm	39.56	27.16	9	13799	228	79730352
Myotonia	39.33	27.16	9	13799	234	79730346
Seizure like phenomena	39.09	27.16	14	13794	1853	79728727
Trigemino-cardiac reflex	38.42	27.16	9	13799	260	79730320
Hyperkalaemia	38.27	27.16	70	13738	114328	79616252
Shock	37.71	27.16	42	13766	43506	79687074
Atrioventricular block second degree	36.48	27.16	20	13788	7292	79723288
Maternal exposure during delivery	35.53	27.16	12	13796	1334	79729246
Peripheral swelling	35.52	27.16	3	13805	269614	79460966
Dizziness	35.29	27.16	24	13784	526417	79204163
Dyskinesia	35.08	27.16	41	13767	44732	79685848
Paralysis	34.78	27.16	24	13784	13153	79717427
Drug intolerance	34.63	27.16	3	13805	264116	79466464
Long QT syndrome	34.52	27.16	18	13790	5937	79724643
Device issue	34.14	27.16	32	13776	27076	79703504
Post procedural stroke	34.12	27.16	7	13801	107	79730473
Blood bicarbonate decreased	33.89	27.16	17	13791	5174	79725406
Atrioventricular block	33.40	27.16	24	13784	14017	79716563
Abdominal pain	33.16	27.16	13	13795	389556	79341024
Constipation	32.67	27.16	5	13803	283045	79447535
Generalised tonic-clonic seizure	32.40	27.16	39	13769	43871	79686709
Chemical peritonitis	32.32	27.16	8	13800	293	79730287
Weight bearing difficulty	31.69	27.16	14	13794	3207	79727373
Upper airway obstruction	31.00	27.16	11	13797	1417	79729163
Sinus tachycardia	30.94	27.16	35	13773	36873	79693707
Heart rate increased	30.86	27.16	66	13742	120658	79609922
Anaphylactoid reaction	30.32	27.16	16	13792	5406	79725174
Anaesthetic complication pulmonary	30.29	27.16	6	13802	76	79730504
Hyperdynamic left ventricle	30.01	27.16	8	13800	395	79730185
Hyperventilation	29.77	27.16	18	13790	7881	79722699
Product dose omission issue	29.43	27.16	4	13804	247533	79483047
Glossoptosis	29.20	27.16	7	13801	224	79730356
Completed suicide	29.15	27.16	4	13804	245763	79484817
Neutropenia	29.15	27.16	7	13801	287703	79442877
Prinzmetal angina	29.00	27.16	11	13797	1709	79728871
Acute pulmonary oedema	28.64	27.16	22	13786	14208	79716372
Light anaesthesia	28.41	27.16	4	13804	3	79730577
Hepatocellular injury	28.36	27.16	38	13770	47555	79683025
Change in seizure presentation	27.96	27.16	8	13800	514	79730066
Oedema peripheral	27.90	27.16	5	13803	252283	79478297
Atrioventricular block complete	27.71	27.16	23	13785	16587	79713993
Polyuria	27.60	27.16	22	13786	14992	79715588
End-tidal CO2 decreased	27.56	27.16	5	13803	38	79730542
Electroencephalogram abnormal	27.48	27.16	15	13793	5419	79725161
Electrocardiogram QT prolonged	27.35	27.16	53	13755	90333	79640247
Agitation	27.21	27.16	56	13752	99659	79630921
Urinary tract infection	27.18	27.16	7	13801	274505	79456075

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N01AB08	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Halogenated hydrocarbons
MeSH PA	D000777	Anesthetics
MeSH PA	D018685	Anesthetics, Inhalation
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D006401	Hematologic Agents
MeSH PA	D010975	Platelet Aggregation Inhibitors
CHEBI has role	CHEBI:35488	central nervous system depressants
CHEBI has role	CHEBI:38870	inhalation anesthetics
CHEBI has role	CHEBI:50427	platelet aggregation inhibitors
FDA EPC	N0000175681	General Anesthetic
FDA PE	N0000175975	General Anesthesia

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
General anesthesia	indication	50697003
Hyperkalemia	contraindication	14140009
Proteinuria	contraindication	29738008	DOID:576
Low blood pressure	contraindication	45007003
Glycosuria	contraindication	45154002
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Duchenne muscular dystrophy	contraindication	76670001	DOID:11723
Kidney disease	contraindication	90708001	DOID:557
Seizure disorder	contraindication	128613002
Disease of liver	contraindication	235856003	DOID:409
Malignant hyperthermia	contraindication	405501007

🐶 Veterinary Drug Use

Species	Use	Relation
Dogs	Induction and maintenance of general anesthesia	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
SevoFlo	Zoetis Inc.	1
Petrem	Piramal Critical Care Inc.	1
Sevoflurane	Dechra Veterinary Products LLC	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Bioact source	MoA source
Glycine receptor subunit alpha-1	Ion channel	P23415	GLRA1_HUMAN	POSITIVE MODULATOR	DRUGBANK	CHEMBL
Potassium channel subfamily K member 2	Ion channel	O95069	KCNK2_HUMAN	OPENER	CHEMBL	CHEMBL
Potassium channel subfamily K member 3	Ion channel	O14649	KCNK3_HUMAN	OPENER	CHEMBL	CHEMBL
Potassium channel subfamily K member 9	Ion channel	Q9NPC2	KCNK9_HUMAN	OPENER	CHEMBL	CHEMBL
Potassium channel subfamily K member 10	Ion channel	P57789	KCNKA_HUMAN	OPENER	CHEMBL	CHEMBL
Potassium channel subfamily K member 18	Ion channel	Q7Z418	KCNKI_HUMAN	OPENER	CHEMBL	CHEMBL
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN	POSITIVE ALLOSTERIC MODULATOR	CHEMBL	CHEMBL

External reference:

ID	Source
4020924	VUID
N0000148409	NUI
D00547	KEGG_DRUG
4020924	VANDF
C0074414	UMLSCUI
CHEBI:9130	CHEBI
CHEMBL1200694	ChEMBL_ID
DB01236	DRUGBANK_ID
D000077149	MESH_DESCRIPTOR_UI
5206	PUBCHEM_CID
3028	INN_ID
7296	IUPHAR_LIGAND_ID
38LVP0K73A	UNII
1245040	RXNORM
7414	MMSL
81183	MMSL
d03845	MMSL
005015	NDDF
108395008	SNOMEDCT_US
386842005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ultane	HUMAN PRESCRIPTION DRUG LABEL	1	0074-4456	LIQUID	250 mL	RESPIRATORY (INHALATION)	NDA	32 sections
Ultane	HUMAN PRESCRIPTION DRUG LABEL	1	0074-4456	LIQUID	250 mL	RESPIRATORY (INHALATION)	NDA	32 sections
Ultane	HUMAN PRESCRIPTION DRUG LABEL	1	0074-4456	LIQUID	250 mL	RESPIRATORY (INHALATION)	NDA	32 sections
Ultane	HUMAN PRESCRIPTION DRUG LABEL	1	0074-4456	LIQUID	250 mL	RESPIRATORY (INHALATION)	NDA	32 sections
Ultane	HUMAN PRESCRIPTION DRUG LABEL	1	0074-4456	LIQUID	250 mL	RESPIRATORY (INHALATION)	NDA	32 sections
Ultane	HUMAN PRESCRIPTION DRUG LABEL	1	0074-4456	LIQUID	250 mL	RESPIRATORY (INHALATION)	NDA	32 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	0781-6160	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	20 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	0781-6160	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	20 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	0781-6160	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	20 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-651	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-651	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-651	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
SEVOFLURANE	HUMAN PRESCRIPTION DRUG LABEL	1	10019-653	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
SEVOFLURANE	HUMAN PRESCRIPTION DRUG LABEL	1	10019-653	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
SEVOFLURANE	HUMAN PRESCRIPTION DRUG LABEL	1	10019-653	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-655	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-655	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
SEVOFLURANE	HUMAN PRESCRIPTION DRUG LABEL	1	10019-657	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
SEVOFLURANE	HUMAN PRESCRIPTION DRUG LABEL	1	10019-657	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	12164-005	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	26 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	12164-005	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	26 sections
Sojourn	HUMAN PRESCRIPTION DRUG LABEL	1	66794-012	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	23 sections
Sojourn	HUMAN PRESCRIPTION DRUG LABEL	1	66794-012	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	23 sections
Sojourn	HUMAN PRESCRIPTION DRUG LABEL	1	66794-012	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	23 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	66794-015	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	23 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	66794-015	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	23 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	66794-015	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	23 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	66794-022	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	15 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	66794-022	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	15 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	66794-022	LIQUID	1 mL	RESPIRATORY (INHALATION)	ANDA	15 sections