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sevoflurane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
halogenated compounds used as general inhalation anaesthetics	2439	28523-86-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sevoflurane sevoflo sevofluran sevofrane sevorane	A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION. Molecular weight: 200.06 Formula: C4H3F7O CLOGP: 1.83 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: 9.23 ALOGS: -2.13 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sevoflurane
sevoflo
sevofluran
sevofrane
sevorane

A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.

Molecular weight: 200.06
Formula: C4H3F7O
CLOGP: 1.83
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA: 9.23
ALOGS: -2.13
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
June 7, 1995	FDA	ABBVIE

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Serotonin syndrome	321.07	33.99	122	7283	28560	63453057
Myoglobin urine present	291.70	33.99	54	7351	718	63480899
Hypotension	288.12	33.99	244	7161	272360	63209257
Drug interaction	266.67	33.99	217	7188	228914	63252703
Delayed recovery from anaesthesia	228.71	33.99	44	7361	727	63480890
Hyperthermia malignant	225.26	33.99	44	7361	790	63480827
Anaphylactic shock	223.51	33.99	89	7316	23544	63458073
Unwanted awareness during anaesthesia	202.73	33.99	35	7370	303	63481314
Bronchospasm	202.26	33.99	76	7329	17204	63464413
Toxic encephalopathy	185.22	33.99	56	7349	6523	63475094

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperthermia malignant	774.92	29.95	159	7121	2018	34947633
Cardiac arrest	237.07	29.95	180	7100	95979	34853672
Anaesthetic complication	235	29.95	53	7227	1067	34948584
Bradycardia	212.30	29.95	153	7127	75265	34874386
Anaphylactic reaction	207.66	29.95	111	7169	32190	34917461
Anaphylactic shock	194.41	29.95	85	7195	15856	34933795
Delayed recovery from anaesthesia	168.55	29.95	38	7242	763	34948888
Hypotension	147.04	29.95	204	7076	221445	34728206
Serotonin syndrome	140.77	29.95	73	7207	19860	34929791
Post procedural complication	139.69	29.95	61	7219	11327	34938324

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperthermia malignant	879.35	27.16	180	13628	2737	79727843
Anaesthetic complication	561.95	27.16	124	13684	2735	79727845
Anaphylactic shock	399.22	27.16	170	13638	35826	79694754
Cardiac arrest	392.99	27.16	286	13522	171810	79558770
Serotonin syndrome	387.65	27.16	178	13630	44849	79685731
Hypotension	375.51	27.16	419	13389	439898	79290682
Delayed recovery from anaesthesia	347.79	27.16	76	13732	1597	79728983
Bradycardia	315.36	27.16	228	13580	135329	79595251
Bronchospasm	280.80	27.16	119	13689	24740	79705840
Anaphylactic reaction	278.80	27.16	176	13632	83567	79647013

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	N01AB08	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Halogenated hydrocarbons
CHEBI has role	CHEBI:35488	central nervous system depressants
CHEBI has role	CHEBI:38870	inhalation anesthetics
CHEBI has role	CHEBI:50427	platelet aggregation inhibitors
FDA EPC	N0000175681	General Anesthetic
FDA PE	N0000175975	General Anesthesia
MeSH PA	D000777	Anesthetics
MeSH PA	D018685	Anesthetics, Inhalation
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
General anesthesia	indication	50697003
Hyperkalemia	contraindication	14140009
Proteinuria	contraindication	29738008	DOID:576
Low blood pressure	contraindication	45007003
Glycosuria	contraindication	45154002
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Duchenne muscular dystrophy	contraindication	76670001	DOID:11723
Kidney disease	contraindication	90708001	DOID:557
Seizure disorder	contraindication	128613002
Disease of liver	contraindication	235856003	DOID:409

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🐶 Veterinary Drug Use

Species	Use	Relation
Dogs	Induction and maintenance of general anesthesia	Indication

🐶 Veterinary products

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Product	Applicant	Ingredients
Petrem	Piramal Critical Care Inc.	1
SevoFlo	Zoetis Inc.	1
Sevoflurane	Dechra Veterinary Products LLC	1

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Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Bioact source	MoA source
Glycine receptor subunit alpha-1	Ion channel	P23415	GLRA1_HUMAN	POSITIVE MODULATOR	DRUGBANK	CHEMBL
Potassium channel subfamily K member 2	Ion channel	O95069	KCNK2_HUMAN	OPENER	CHEMBL	CHEMBL
Potassium channel subfamily K member 3	Ion channel	O14649	KCNK3_HUMAN	OPENER	CHEMBL	CHEMBL
Potassium channel subfamily K member 9	Ion channel	Q9NPC2	KCNK9_HUMAN	OPENER	CHEMBL	CHEMBL
Potassium channel subfamily K member 10	Ion channel	P57789	KCNKA_HUMAN	OPENER	CHEMBL	CHEMBL
Potassium channel subfamily K member 18	Ion channel	Q7Z418	KCNKI_HUMAN	OPENER	CHEMBL	CHEMBL
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN	POSITIVE ALLOSTERIC MODULATOR	CHEMBL	CHEMBL

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External reference:

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ID	Source
005015	NDDF
108395008	SNOMEDCT_US
1245040	RXNORM
3028	INN_ID
386842005	SNOMEDCT_US
38LVP0K73A	UNII
4020924	VUID
4020924	VANDF
5206	PUBCHEM_CID
7296	IUPHAR_LIGAND_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	0781-6160	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	20 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	0781-6160	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	20 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	0781-6160	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	20 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-651	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-651	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-651	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
SEVOFLURANE	HUMAN PRESCRIPTION DRUG LABEL	1	10019-653	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
SEVOFLURANE	HUMAN PRESCRIPTION DRUG LABEL	1	10019-653	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
SEVOFLURANE	HUMAN PRESCRIPTION DRUG LABEL	1	10019-653	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections
Sevoflurane	HUMAN PRESCRIPTION DRUG LABEL	1	10019-655	LIQUID	250 mL	RESPIRATORY (INHALATION)	ANDA	27 sections

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