salsalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
analgesic anti-inflammatory 2420 552-94-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salsalate
  • salicylic acid salicylate
  • disalicylic acid
  • salicyl salicylate
  • salicyloxysalicylic acid
  • salicyloylsalicylic acid
  • salicylsalicylic acid
  • sasapyrine
  • Molecular weight: 258.23
  • Formula: C14H10O5
  • CLOGP: 3.35
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 83.83
  • ALOGS: -3.02
  • ROTB: 4

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
International normalised ratio increased 35.96 30.46 15 376 47312 34909228

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 29.18 25.86 22 627 298894 79444845

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BA06 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35526 antidiabetic
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35625 beta-lactamase inhibitors
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:35718 antifungal agents
CHEBI has role CHEBI:37848 plant hormones
CHEBI has role CHEBI:50176 keratolytic drugs
CHEBI has role CHEBI:73181 ascorbate peroxidase inhibitor
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:84735 algal metabolites
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D007641 Keratolytic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Osteoarthritis indication 396275006
Gastritis contraindication 4556007 DOID:4029
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Anemia due to enzyme deficiency contraindication 111577008
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.37 acidic
pKa2 9.43 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018818 VUID
N0000179234 NUI
D00428 KEGG_DRUG
4018663 VANDF
4018818 VANDF
C0073983 UMLSCUI
CHEBI:9014 CHEBI
CHEBI:16914 CHEBI
SAL PDB_CHEM_ID
CHEMBL154111 ChEMBL_ID
DB01399 DRUGBANK_ID
C014182 MESH_SUPPLEMENTAL_RECORD_UI
5161 PUBCHEM_CID
3267 INN_ID
V9MO595C9I UNII
36108 RXNORM
1419 MMSL
5439 MMSL
5441 MMSL
9170 MMSL
d00842 MMSL
001596 NDDF
001951 NDDF
13252002 SNOMEDCT_US
387072007 SNOMEDCT_US
387253001 SNOMEDCT_US
46741005 SNOMEDCT_US
C0036079 UMLSCUI
DB00936 DRUGBANK_ID
D020156 MESH_DESCRIPTOR_UI
338 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 10135-492 TABLET, FILM COATED 500 mg ORAL UNAPPROVED DRUG OTHER 27 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 10135-493 TABLET, FILM COATED 750 mg ORAL UNAPPROVED DRUG OTHER 27 sections
Salsalate Rx HUMAN PRESCRIPTION DRUG LABEL 1 13273-209 TABLET, FILM COATED 500 mg ORAL UNAPPROVED DRUG OTHER 28 sections
Salsalate Rx HUMAN PRESCRIPTION DRUG LABEL 1 13273-210 TABLET, FILM COATED 750 mg ORAL UNAPPROVED DRUG OTHER 28 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 21695-392 TABLET 750 mg ORAL Unapproved drug other 28 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 42192-365 TABLET 500 mg ORAL unapproved drug other 27 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 42192-366 TABLET 750 mg ORAL unapproved drug other 27 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 43063-577 TABLET 750 mg ORAL unapproved drug other 27 sections
SALSALATE HUMAN PRESCRIPTION DRUG LABEL 1 43353-771 TABLET 750 mg ORAL Unapproved drug other 26 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 50682-507 TABLET, FILM COATED 500 mg ORAL Unapproved drug other 25 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 50682-508 TABLET, FILM COATED 750 mg ORAL Unapproved drug other 25 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 51293-615 TABLET 500 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 51293-615 TABLET 500 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 51293-615 TABLET 500 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 51293-616 TABLET 750 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 51293-616 TABLET 750 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 51293-616 TABLET 750 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 51293-803 TABLET 500 mg ORAL Unapproved drug other 14 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 51293-804 TABLET 750 mg ORAL Unapproved drug other 14 sections
Salsalate Human Prescription Drug Label 1 57664-103 TABLET 500 mg ORAL Unapproved drug other 28 sections
Salsalate Human Prescription Drug Label 1 57664-105 TABLET 750 mg ORAL Unapproved drug other 28 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 63629-2150 TABLET 750 mg ORAL UNAPPROVED DRUG OTHER 18 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 63629-2150 TABLET 750 mg ORAL UNAPPROVED DRUG OTHER 18 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 63629-2150 TABLET 750 mg ORAL UNAPPROVED DRUG OTHER 18 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 63629-2440 TABLET 500 mg ORAL Unapproved drug other 14 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 63629-2441 TABLET 500 mg ORAL Unapproved drug other 14 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 63629-8416 TABLET 750 mg ORAL Unapproved drug other 17 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 63629-8416 TABLET 750 mg ORAL Unapproved drug other 17 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 63629-8997 TABLET 750 mg ORAL UNAPPROVED DRUG OTHER 18 sections
Salsalate HUMAN PRESCRIPTION DRUG LABEL 1 63629-8997 TABLET 750 mg ORAL UNAPPROVED DRUG OTHER 18 sections