rubitecan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, topoisomerase I inhibitors 2411 91421-42-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rubitecan
  • 9-Nitrocamptothecin
  • orathecin
  • Molecular weight: 393.36
  • Formula: C20H15N3O6
  • CLOGP: 1.06
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 125.55
  • ALOGS: -3.22
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059004 Topoisomerase I Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:50276 topoisomerase I inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.46 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D04031 KEGG_DRUG
C0213800 UMLSCUI
CHEBI:90225 CHEBI
CHEMBL77305 ChEMBL_ID
DB06159 DRUGBANK_ID
C079905 MESH_SUPPLEMENTAL_RECORD_UI
472335 PUBCHEM_CID
7946 INN_ID
H19C446XXB UNII

Pharmaceutical products:

None