rocuronium ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
neuromuscular blocking agents with rigid structure 2396 119302-91-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ORG-9426
  • ORG 9426
  • rocuronium
  • rocuronium bromide
  • zemuron
  • esmeron
Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.
  • Molecular weight: 529.79
  • Formula: C32H53N2O4
  • CLOGP: 2.23
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 1
  • TPSA: 59
  • ALOGS: -7.30
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 17 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.38 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.54 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.60 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 122 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
March 17, 1994 FDA ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic reaction 1481.02 30.01 516 10296 65584 63412626
Anaphylactic shock 1231.55 30.01 352 10460 23281 63454929
Hypotension 544.63 30.01 414 10398 272190 63206020
Cardiac arrest 456.53 30.01 249 10563 92296 63385914
Neuromuscular block prolonged 434.58 30.01 76 10736 466 63477744
Bronchospasm 404.54 30.01 140 10672 17140 63461070
Serotonin syndrome 318.77 30.01 135 10677 28547 63449663
Myoglobin urine present 259.23 30.01 52 10760 720 63477490
Circulatory collapse 239.49 30.01 102 10710 21836 63456374
Delayed recovery from anaesthesia 223.74 30.01 46 10766 725 63477485
Stress cardiomyopathy 214.99 30.01 75 10737 9375 63468835
Tachycardia 209.66 30.01 168 10644 117988 63360222
Drug interaction 204.55 30.01 222 10590 228909 63249301
Recurrence of neuromuscular blockade 197.64 30.01 32 10780 112 63478098
Bradycardia 185.50 30.01 129 10683 73098 63405112
Amylase increased 162.36 30.01 55 10757 6290 63471920
Toxic encephalopathy 156.52 30.01 54 10758 6525 63471685
Kounis syndrome 147.03 30.01 38 10774 1692 63476518
Therapeutic product effect prolonged 137.54 30.01 27 10785 332 63477878
Troponin increased 133.86 30.01 54 10758 10067 63468143
Unwanted awareness during anaesthesia 120.88 30.01 24 10788 314 63477896
Hypoventilation 112.99 30.01 39 10773 4715 63473495
Blood lactate dehydrogenase increased 104.80 30.01 59 10753 23057 63455153
Fatigue 104.79 30.01 14 10798 888014 62590196
Wrist surgery 103.24 30.01 25 10787 850 63477360
Airway peak pressure increased 99.80 30.01 20 10792 275 63477935
Blood potassium increased 97.56 30.01 52 10760 18257 63459953
Pulseless electrical activity 95.57 30.01 39 10773 7482 63470728
Neuromuscular blockade 93.65 30.01 19 10793 279 63477931
Ventricular tachycardia 93.30 30.01 52 10760 19927 63458283
Finger deformity 91.09 30.01 38 10774 7707 63470503
Paralysis 88.42 30.01 40 10772 9860 63468350
Haemodynamic instability 88.04 30.01 39 10773 9151 63469059
Oxygen saturation decreased 87.89 30.01 91 10721 88494 63389716
Blood creatine phosphokinase increased 87.39 30.01 58 10754 30372 63447838
Blood pressure decreased 85.55 30.01 78 10734 64944 63413266
Hyperthermia malignant 84.08 30.01 21 10791 813 63477397
Premature delivery 82.84 30.01 56 10756 30225 63447985
Maternal exposure during delivery 80.79 30.01 23 10789 1477 63476733
Breast cancer recurrent 78.19 30.01 29 10783 4312 63473898
Hypoxia 77.24 30.01 71 10741 59721 63418489
Arthralgia 74.71 30.01 6 10806 569704 62908506
Urticaria 72.28 30.01 113 10699 165689 63312521
Diarrhoea 71.86 30.01 17 10795 715349 62762861
Nausea 68.77 30.01 30 10782 854441 62623769
Headache 67.75 30.01 13 10799 633228 62844982
Anaphylactoid reaction 67.53 30.01 25 10787 3698 63474512
Tenosynovitis 67.41 30.01 37 10775 13758 63464452
Apnoea 67.19 30.01 31 10781 7991 63470219
Limb operation 65.59 30.01 25 10787 4006 63474204
Ventricular fibrillation 64.04 30.01 34 10778 11833 63466377
Dystonia 59.20 30.01 34 10778 13785 63464425
Anticholinergic syndrome 58.38 30.01 20 10792 2362 63475848
Anaesthetic complication 58.14 30.01 19 10793 1941 63476269
Type I hypersensitivity 57.97 30.01 21 10791 2921 63475289
Exposure during pregnancy 56.93 30.01 98 10714 155449 63322761
Procedural hypotension 54.12 30.01 16 10796 1174 63477036
Endotracheal intubation complication 53.91 30.01 13 10799 434 63477776
Vasoplegia syndrome 52.55 30.01 17 10795 1682 63476528
Anaphylactoid shock 52.18 30.01 12 10800 325 63477885
Airway complication of anaesthesia 51.75 30.01 11 10801 205 63478005
Alanine aminotransferase increased 48.36 30.01 73 10739 103697 63374513
Postoperative delirium 47.73 30.01 9 10803 88 63478122
Respiratory acidosis 47.20 30.01 23 10789 6692 63471518
Subcutaneous emphysema 45.38 30.01 13 10799 853 63477357
Fall 44.19 30.01 7 10805 392327 63085883
Carcinoid crisis 44.02 30.01 10 10802 256 63477954
Hyperreflexia 43.74 30.01 21 10791 5913 63472297
Skin test positive 42.94 30.01 12 10800 720 63477490
Angioedema 41.74 30.01 46 10766 47919 63430291
Diabetes insipidus 41.70 30.01 16 10796 2609 63475601
Laryngeal oedema 41.44 30.01 20 10792 5698 63472512
Vomiting 41.30 30.01 22 10790 559595 62918615
Altered state of consciousness 40.67 30.01 34 10778 25196 63453014
Muscle rigidity 40.65 30.01 25 10787 11475 63466735
Abdominal discomfort 40.31 30.01 4 10808 320881 63157329
Pulmonary oedema 39.96 30.01 48 10764 54825 63423385
Tracheal injury 39.08 30.01 7 10805 50 63478160
Neuromuscular blocking therapy 38.39 30.01 5 10807 0 63478210
Pain 38.27 30.01 42 10770 740586 62737624
Therapeutic product effect increased 36.94 30.01 12 10800 1203 63477007
Clonus 35.98 30.01 17 10795 4619 63473591
Respiratory arrest 35.00 30.01 35 10777 32610 63445600
Pain in extremity 34.95 30.01 7 10805 331479 63146731
Torsade de pointes 34.86 30.01 24 10788 13327 63464883
Atrioventricular dissociation 34.74 30.01 8 10804 218 63477992
Isoimmune haemolytic disease 34.26 30.01 6 10806 37 63478173
Myasthenic syndrome 33.62 30.01 8 10804 252 63477958
Dizziness 33.03 30.01 16 10796 429909 63048301
Multiple organ dysfunction syndrome 32.41 30.01 44 10768 56708 63421502
Unresponsive to stimuli 32.17 30.01 34 10778 33782 63444428
Post procedural stroke 32.17 30.01 6 10806 55 63478155
Decreased appetite 31.86 30.01 3 10809 251049 63227161
Death 31.84 30.01 12 10800 374369 63103841
Pruritus 31.73 30.01 11 10801 361442 63116768
Pulmonary hypertensive crisis 31.40 30.01 8 10804 336 63477874
Irregular breathing 31.30 30.01 8 10804 340 63477870
Cardiac output decreased 31.18 30.01 10 10802 962 63477248
Allergy test positive 31.12 30.01 9 10803 611 63477599
Neurodevelopmental disorder 31.01 30.01 7 10805 174 63478036
Erythema 30.70 30.01 82 10730 175669 63302541
Muscle twitching 30.66 30.01 26 10786 19642 63458568
Coronary artery embolism 30.60 30.01 7 10805 185 63478025
Maternal exposure during pregnancy 30.07 30.01 94 10718 219968 63258242
Mydriasis 30.06 30.01 21 10791 11935 63466275

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 998.58 23.20 306 9426 15635 34931564
Anaphylactic reaction 765.61 23.20 300 9432 32001 34915198
Hyperthermia malignant 463.36 23.20 110 9622 2067 34945132
Neuromuscular block prolonged 310.25 23.20 61 9671 440 34946759
Bronchospasm 279.43 23.20 107 9625 10624 34936575
Hypotension 271.88 23.20 320 9412 221329 34725870
Recurrence of neuromuscular blockade 238.01 23.20 43 9689 182 34947017
Cardiac arrest 232.56 23.20 201 9531 95958 34851241
Bradycardia 186.93 23.20 160 9572 75258 34871941
Delayed recovery from anaesthesia 162.70 23.20 39 9693 762 34946437
Kounis syndrome 114.50 23.20 38 9694 2480 34944719
Neuromuscular blockade 108.91 23.20 23 9709 245 34946954
Negative pressure pulmonary oedema 106.27 23.20 22 9710 211 34946988
Pulseless electrical activity 103.31 23.20 47 9685 7164 34940035
Respiratory depression 102.40 23.20 61 9671 16184 34931015
Tachycardia 94.36 23.20 117 9615 84655 34862544
Anaesthetic complication 93.80 23.20 27 9705 1093 34946106
Blood pressure decreased 88.10 23.20 89 9643 51426 34895773
Circulatory collapse 87.95 23.20 61 9671 20977 34926222
Endotracheal intubation complication 84.50 23.20 20 9712 369 34946830
Electrocardiogram ST segment elevation 84.17 23.20 37 9695 5201 34941998
Hypoventilation 78.03 23.20 31 9701 3383 34943816
Fatigue 77.83 23.20 7 9725 370646 34576553
Oxygen saturation decreased 77.77 23.20 85 9647 53733 34893466
Haemodynamic instability 76.76 23.20 42 9690 9481 34937718
Arteriospasm coronary 71.38 23.20 29 9703 3353 34943846
Procedural hypotension 67.09 23.20 20 9712 916 34946283
Airway complication of anaesthesia 66.82 23.20 14 9718 143 34947056
Ventricular fibrillation 61.42 23.20 51 9681 22903 34924296
Hypoxia 61.16 23.20 76 9656 55019 34892180
Ventricular tachycardia 58.86 23.20 53 9679 26526 34920673
Diabetes insipidus 58.02 23.20 24 9708 2904 34944295
Respiratory arrest 56.42 23.20 53 9679 27990 34919209
Multiple organ dysfunction syndrome 55.49 23.20 86 9646 76480 34870719
Serotonin syndrome 54.81 23.20 45 9687 19888 34927311
Respiratory acidosis 51.29 23.20 26 9706 5024 34942175
Hypercapnia 49.42 23.20 24 9708 4231 34942968
Airway peak pressure increased 47.77 23.20 8 9724 19 34947180
Drug ineffective 46.95 23.20 250 9482 456501 34490698
Intensive care unit acquired weakness 44.70 23.20 15 9717 1012 34946187
Unwanted awareness during anaesthesia 44.63 23.20 8 9724 32 34947167
Pulmonary alveolar haemorrhage 44.19 23.20 27 9705 7485 34939714
Rhabdomyolysis 43.13 23.20 72 9660 68091 34879108
Respiratory failure 43.09 23.20 94 9638 108478 34838721
Death 41.96 23.20 30 9702 398019 34549180
Burkholderia test positive 40.83 23.20 14 9718 1009 34946190
Allergy test negative 40.62 23.20 9 9723 122 34947077
Diarrhoea 40.29 23.20 30 9702 389882 34557317
Cardio-respiratory arrest 39.90 23.20 62 9670 55211 34891988
Brain oedema 39.67 23.20 32 9700 13789 34933410
Urticaria 39.61 23.20 66 9666 62311 34884888
Acidosis 39.42 23.20 29 9703 10916 34936283
Hypoxic-ischaemic encephalopathy 39.34 23.20 21 9711 4511 34942688
Pulmonary oedema 38.12 23.20 56 9676 47473 34899726
Shock 38.07 23.20 40 9692 24139 34923060
Anaesthetic complication neurological 36.73 23.20 10 9722 329 34946870
Decreased appetite 35.21 23.20 3 9729 166389 34780810
Thyrotoxic crisis 34.73 23.20 10 9722 405 34946794
Hypotonic-hyporesponsive episode 33.68 23.20 6 9726 23 34947176
Arthralgia 33.55 23.20 4 9728 170037 34777162
Therapeutic product effect decreased 32.39 23.20 44 9688 34699 34912500
Trigemino-cardiac reflex 32.08 23.20 8 9724 185 34947014
Hyperkalaemia 32.08 23.20 64 9668 69325 34877874
Tachypnoea 31.86 23.20 32 9700 18320 34928879
Endotracheal intubation 31.77 23.20 16 9716 3049 34944150
Drug reaction with eosinophilia and systemic symptoms 31.07 23.20 42 9690 32970 34914229
Headache 30.54 23.20 9 9723 200626 34746573
Blood catecholamines increased 30.45 23.20 5 9727 10 34947189
Propofol infusion syndrome 30.10 23.20 11 9721 955 34946244
Therapeutic product effect prolonged 29.69 23.20 8 9724 253 34946946
Prinzmetal angina 29.53 23.20 11 9721 1008 34946191
Dizziness 29.48 23.20 12 9720 218509 34728690
Muscle rigidity 29.44 23.20 24 9708 10494 34936705
Fall 29.28 23.20 10 9722 202875 34744324
Acute respiratory distress syndrome 29.06 23.20 36 9696 25933 34921266
Laryngospasm 28.56 23.20 12 9720 1509 34945690
Apnoea 27.07 23.20 19 9713 6645 34940554
Product measured potency issue 26.70 23.20 6 9726 87 34947112
Anaphylactoid reaction 26.65 23.20 13 9719 2312 34944887
Catecholamine crisis 25.67 23.20 5 9727 34 34947165
Anaemia 25.29 23.20 17 9715 233318 34713881
Nausea 25.00 23.20 35 9697 339873 34607326
Oromandibular dystonia 24.54 23.20 8 9724 493 34946706
Procedural complication 24.18 23.20 15 9717 4268 34942931
Sinus arrest 23.84 23.20 11 9721 1729 34945470
Malaise 23.79 23.20 11 9721 185814 34761385
Metabolic acidosis 23.52 23.20 43 9689 43637 34903562
Atrioventricular block complete 23.46 23.20 20 9712 9299 34937900
Dehydration 23.43 23.20 4 9728 129965 34817234
Phaeochromocytoma crisis 23.28 23.20 5 9727 58 34947141

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 2132.28 23.12 642 18823 35354 79689569
Anaphylactic reaction 2059.29 23.12 770 18695 82973 79641950
Hypotension 715.00 23.12 693 18772 439624 79285299
Neuromuscular block prolonged 708.03 23.12 134 19331 896 79724027
Bronchospasm 635.39 23.12 236 19229 24623 79700300
Cardiac arrest 630.18 23.12 436 19029 171660 79553263
Hyperthermia malignant 522.11 23.12 125 19340 2792 79722131
Delayed recovery from anaesthesia 353.37 23.12 82 19383 1591 79723332
Recurrence of neuromuscular blockade 352.33 23.12 62 19403 257 79724666
Bradycardia 327.12 23.12 268 19197 135289 79589634
Serotonin syndrome 315.50 23.12 173 19292 44854 79680069
Circulatory collapse 298.27 23.12 157 19308 37511 79687412
Tachycardia 275.71 23.12 274 19191 177494 79547429
Kounis syndrome 250.97 23.12 76 19389 4206 79720717
Myoglobin urine present 208.41 23.12 48 19417 899 79724024
Stress cardiomyopathy 203.43 23.12 83 19382 11083 79713840
Pulseless electrical activity 190.84 23.12 85 19380 14075 79710848
Neuromuscular blockade 180.30 23.12 39 19426 541 79724382
Blood pressure decreased 168.34 23.12 161 19304 99305 79625618
Drug interaction 158.73 23.12 327 19138 414856 79310067
Fatigue 157.05 23.12 21 19444 929706 78795217
Hypoventilation 153.48 23.12 60 19405 7164 79717759
Haemodynamic instability 153.48 23.12 78 19387 17304 79707619
Oxygen saturation decreased 146.90 23.12 169 19296 128878 79596045
Ventricular tachycardia 140.66 23.12 101 19364 41834 79683089
Airway peak pressure increased 134.61 23.12 28 19437 318 79724605
Anaesthetic complication 130.83 23.12 42 19423 2817 79722106
Unwanted awareness during anaesthesia 130.43 23.12 27 19438 299 79724624
Airway complication of anaesthesia 129.20 23.12 28 19437 392 79724531
Procedural hypotension 127.57 23.12 38 19427 1985 79722938
Ventricular fibrillation 121.29 23.12 83 19382 31843 79693080
Hypoxia 118.78 23.12 136 19329 103107 79621816
Endotracheal intubation complication 115.45 23.12 29 19436 793 79724130
Electrocardiogram ST segment elevation 115.03 23.12 51 19414 8346 79716577
Therapeutic product effect prolonged 114.98 23.12 27 19438 552 79724371
Negative pressure pulmonary oedema 114.64 23.12 23 19442 215 79724708
Amylase increased 109.86 23.12 54 19411 11155 79713768
Diarrhoea 106.78 23.12 41 19424 880448 78844475
Arthralgia 103.65 23.12 10 19455 571793 79153130
Diabetes insipidus 99.05 23.12 40 19425 5197 79719726
Toxic encephalopathy 97.11 23.12 50 19415 11390 79713533
Arteriospasm coronary 95.90 23.12 42 19423 6674 79718249
Headache 94.48 23.12 22 19443 653750 79071173
Urticaria 92.91 23.12 164 19301 185037 79539886
Respiratory depression 91.38 23.12 66 19399 27564 79697359
Paralysis 90.46 23.12 50 19415 13127 79711796
Nausea 90.16 23.12 62 19403 957134 78767789
Respiratory acidosis 89.47 23.12 47 19418 11153 79713770
Troponin increased 85.05 23.12 55 19410 19200 79705723
Anaphylactoid reaction 84.27 23.12 36 19429 5386 79719537
Respiratory arrest 80.40 23.12 84 19381 57466 79667457
Apnoea 79.22 23.12 44 19421 11660 79713263
Multiple organ dysfunction syndrome 75.73 23.12 118 19347 120128 79604795
Pulmonary oedema 73.68 23.12 99 19366 88155 79636768
Fall 73.24 23.12 15 19450 487614 79237309
Anticholinergic syndrome 73.21 23.12 29 19436 3582 79721341
Maternal exposure during delivery 70.83 23.12 22 19443 1324 79723599
Hypercapnia 69.97 23.12 37 19428 8898 79716025
Vomiting 65.44 23.12 41 19424 665787 79059136
Muscle rigidity 64.61 23.12 47 19418 19835 79705088
Type I hypersensitivity 64.41 23.12 28 19437 4370 79720553
Pain in extremity 64.36 23.12 7 19458 364531 79360392
Dystonia 63.74 23.12 48 19417 21351 79703572
Wrist surgery 63.26 23.12 18 19447 799 79724124
Dizziness 62.85 23.12 25 19440 526416 79198507
Respiratory failure 62.49 23.12 137 19328 180774 79544149
Decreased appetite 61.93 23.12 6 19459 342412 79382511
Skin test positive 60.99 23.12 19 19446 1155 79723768
Anaphylactoid shock 59.54 23.12 17 19448 764 79724159
Laryngospasm 57.08 23.12 25 19440 3972 79720951
Postoperative delirium 56.97 23.12 14 19451 349 79724574
Carcinoid crisis 56.63 23.12 15 19450 508 79724415
Blood potassium increased 56.43 23.12 51 19414 29224 79695699
Blood lactate dehydrogenase increased 56.18 23.12 58 19407 39112 79685811
Trigemino-cardiac reflex 55.82 23.12 13 19452 256 79724667
Weight increased 55.47 23.12 3 19462 277383 79447540
Shock 54.53 23.12 60 19405 43488 79681435
Neutropenia 52.13 23.12 5 19460 287705 79437218
Death 51.46 23.12 38 19427 566476 79158447
Blood creatine phosphokinase increased 50.42 23.12 71 19394 66019 79658904
Malaise 49.70 23.12 29 19436 489840 79235083
Weight decreased 49.17 23.12 13 19452 355185 79369738
Anaesthetic complication neurological 49.01 23.12 14 19451 630 79724293
Pulmonary alveolar haemorrhage 48.81 23.12 32 19433 11425 79713498
Back pain 48.54 23.12 8 19457 304172 79420751
Laryngeal oedema 48.12 23.12 28 19437 8101 79716822
Angioedema 46.99 23.12 74 19391 75961 79648962
Pain 46.92 23.12 62 19403 703740 79021183
Procedural complication 45.94 23.12 27 19438 7956 79716967
Premature delivery 45.46 23.12 41 19424 23426 79701497
Pruritus 45.04 23.12 20 19445 394628 79330295
Finger deformity 44.92 23.12 26 19439 7448 79717475
Infusion related reaction 44.48 23.12 3 19462 230234 79494689
Endotracheal intubation 44.15 23.12 22 19443 4675 79720248
Erythema 43.95 23.12 137 19328 223153 79501770
Hypoxic-ischaemic encephalopathy 43.83 23.12 26 19439 7794 79717129
Abdominal discomfort 43.76 23.12 5 19460 250722 79474201
Acidosis 43.23 23.12 37 19428 19725 79705198
Vasoplegia syndrome 43.23 23.12 20 19445 3610 79721313
Subcutaneous emphysema 42.02 23.12 16 19449 1778 79723145
Cardio-respiratory arrest 41.86 23.12 86 19379 108424 79616499
Exposure during pregnancy 41.21 23.12 82 19383 101050 79623873
Anaesthetic complication pulmonary 39.95 23.12 8 19457 74 79724849
Asthenia 39.54 23.12 40 19425 511649 79213274
Thyrotoxic crisis 39.51 23.12 14 19451 1270 79723653
Clonus 39.01 23.12 23 19442 6817 79718106
Drug reaction with eosinophilia and systemic symptoms 38.97 23.12 62 19403 64182 79660741
Anaemia 38.91 23.12 31 19434 444984 79279939
Procedural haemorrhage 38.30 23.12 20 19445 4686 79720237
Limb operation 38.09 23.12 18 19447 3408 79721515
Upper airway obstruction 38.06 23.12 14 19451 1414 79723509
Drug ineffective 37.87 23.12 416 19049 1080497 78644426
Atrioventricular dissociation 37.83 23.12 10 19455 336 79724587
Rhabdomyolysis 37.75 23.12 80 19385 103051 79621872
Product measured potency issue 37.70 23.12 9 19456 198 79724725
Atrioventricular block second degree 37.59 23.12 23 19442 7289 79717634
Intensive care unit acquired weakness 37.37 23.12 15 19450 1918 79723005
Post procedural haemorrhage 36.92 23.12 29 19436 13715 79711208
Gait disturbance 36.55 23.12 4 19461 207502 79517421
Accelerated idioventricular rhythm 36.48 23.12 9 19456 228 79724695
Dehydration 36.46 23.12 8 19457 248179 79476744
Insomnia 35.82 23.12 8 19457 245162 79479761
Hypertensive crisis 35.80 23.12 34 19431 20736 79704187
Infection 35.08 23.12 8 19457 241704 79483219
Allergy test positive 34.56 23.12 11 19454 717 79724206
Tracheal injury 34.46 23.12 7 19458 70 79724853
Hypotonia 34.24 23.12 27 19438 12843 79712080
Sinus arrest 34.15 23.12 17 19448 3605 79721318
Atrioventricular block complete 34.11 23.12 30 19435 16580 79708343
Sinusitis 33.85 23.12 4 19461 195497 79529426
Propofol infusion syndrome 33.59 23.12 14 19451 1969 79722954
Allergy test negative 33.42 23.12 9 19456 325 79724598
Therapeutic product effect increased 33.19 23.12 13 19452 1558 79723365
Abdominal pain 32.97 23.12 28 19437 389541 79335382
Neuromuscular blocking therapy 32.65 23.12 5 19460 6 79724917
Torsade de pointes 32.12 23.12 31 19434 19281 79705642
Hyperdynamic left ventricle 31.75 23.12 9 19456 394 79724529
Acute respiratory distress syndrome 31.63 23.12 46 19419 44021 79680902
Hypothermia 31.39 23.12 33 19432 22713 79702210
Pneumonia 31.35 23.12 72 19393 660174 79064749
Abdominal pain upper 31.32 23.12 8 19457 223811 79501112
Hyperreflexia 29.95 23.12 21 19444 8364 79716559
Tachypnoea 29.89 23.12 38 19427 32025 79692898
Urinary tract infection 29.63 23.12 15 19450 274497 79450426
Coronary artery embolism 29.06 23.12 8 19457 314 79724609
Completed suicide 28.74 23.12 12 19453 245755 79479168
Phaeochromocytoma crisis 28.70 23.12 8 19457 329 79724594
Pulse absent 28.62 23.12 22 19443 10081 79714842
Pyrexia 28.36 23.12 79 19386 678630 79046293
Spinal cord infarction 27.88 23.12 9 19456 614 79724309
Tenosynovitis 27.83 23.12 26 19439 15528 79709395
Supraventricular tachycardia 27.83 23.12 30 19435 21240 79703683
Product administered to patient of inappropriate age 27.36 23.12 17 19448 5536 79719387
Dyskinesia 26.86 23.12 43 19422 44730 79680193
Post procedural complication 26.71 23.12 31 19434 23798 79701125
Post procedural stroke 26.27 23.12 6 19459 108 79724815
Paraplegia 26.24 23.12 16 19449 5037 79719886
COVID-19 treatment 26.07 23.12 8 19457 462 79724461
Renal injury 25.97 23.12 26 19439 16901 79708022
Febrile neutropenia 25.87 23.12 12 19453 230987 79493936
Blood catecholamines increased 25.84 23.12 5 19460 38 79724885
Muscle twitching 25.74 23.12 31 19434 24733 79700190
Prinzmetal angina 25.35 23.12 11 19454 1709 79723214
Irregular breathing 25.31 23.12 8 19457 510 79724413
Resuscitation 24.81 23.12 12 19453 2392 79722531
Catecholamine crisis 24.71 23.12 5 19460 49 79724874
Electrocardiogram ST segment depression 24.20 23.12 15 19450 4863 79720060
Fear 23.64 23.12 28 19437 21958 79702965
Altered state of consciousness 23.48 23.12 40 19425 43782 79681141
Mydriasis 23.29 23.12 25 19440 17618 79707305

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03AC09 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
Other quaternary ammonium compounds
MeSH PA D009465 Neuromuscular Agents
MeSH PA D009466 Neuromuscular Blocking Agents
MeSH PA D003473 Neuromuscular Nondepolarizing Agents
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:51371 muscle relaxants
FDA EPC N0000175720 Nondepolarizing Neuromuscular Blocker
FDA PE N0000175732 Neuromuscular Nondepolarizing Blockade

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Muscle relaxation, function indication 11977004
General anesthesia indication 50697003
Skeletal Muscle Relaxation for Endotracheal Intubation indication
Respiratory acidosis contraindication 12326000
Alkalosis contraindication 21420006
Acidosis contraindication 51387008
Eaton-Lambert syndrome contraindication 56989000 DOID:0050214
Pulmonary hypertension contraindication 70995007 DOID:6432
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Respiratory alkalosis contraindication 111378004
Disease of liver contraindication 235856003 DOID:409
Disorder of electrolytes contraindication 237840007
Malignant hyperthermia contraindication 405501007




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholine receptor Ion channel ANTAGONIST IC50 7.77 WOMBAT-PK CHEMBL
Acetylcholine receptor; alpha1/beta1/delta/gamma Ion channel IC50 7.09 CHEMBL

External reference:

IDSource
D00765 KEGG_DRUG
4020866 VANDF
C0209337 UMLSCUI
CHEBI:8885 CHEBI
RBR PDB_CHEM_ID
CHEMBL1201244 ChEMBL_ID
CHEMBL1200648 ChEMBL_ID
D000077123 MESH_DESCRIPTOR_UI
DB00728 DRUGBANK_ID
4003 IUPHAR_LIGAND_ID
WRE554RFEZ UNII
441290 PUBCHEM_CID
151718 RXNORM
1460 MMSL
159147 MMSL
5433 MMSL
d03766 MMSL
004442 NDDF
013418 NDDF
108449002 SNOMEDCT_US
108450002 SNOMEDCT_US
372494005 SNOMEDCT_US
6864 INN_ID
143558-00-3 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9250 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9250 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9251 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9251 INJECTION 10 mg INTRAVENOUS ANDA 26 sections
rocuronium bromide Human Prescription Drug Label 1 0409-3189 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
rocuronium bromide Human Prescription Drug Label 1 0409-7037 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0409-9558 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0409-9558 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3220 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 0781-3220 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 25021-662 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 27 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 39822-4200 SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
rocuronium bromide HUMAN PRESCRIPTION DRUG LABEL 1 39822-4200 SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 43066-007 INJECTION 50 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 43066-007 INJECTION 50 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 43066-013 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
Rocuronium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 43066-013 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 43547-530 INJECTION 50 mg INTRAVENOUS ANDA 25 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 43547-531 INJECTION 100 mg INTRAVENOUS ANDA 25 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1354 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 18 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1355 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 18 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1545 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 17 sections
ROCURONIUM BROMIDE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1546 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 17 sections
Rocuronium Bromide Human Prescription Drug Label 1 55150-225 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 25 sections
Rocuronium Bromide Human Prescription Drug Label 1 55150-225 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 25 sections
Rocuronium Bromide Human Prescription Drug Label 1 55150-226 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 25 sections
Rocuronium Bromide Human Prescription Drug Label 1 55150-226 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 25 sections
Rocuronium HUMAN PRESCRIPTION DRUG LABEL 1 63323-426 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium HUMAN PRESCRIPTION DRUG LABEL 1 63323-426 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections
Rocuronium HUMAN PRESCRIPTION DRUG LABEL 1 63323-426 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections