ritonavir Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
HIV protease inhibitors 2391 155213-67-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ABT538
  • ABT-538
  • ritonavir
  • norvir
Ritonavir is a peptidomimetic inhibitor of the HIV-1 protease. Inhibition of HIV protease renders the enzyme incapable of processing the Gag-Pol polyprotein precursor which leads to production of non-infectious immature HIV particles.
  • Molecular weight: 720.95
  • Formula: C37H48N6O5S2
  • CLOGP: 4.94
  • LIPINSKI: 2
  • HAC: 11
  • HDO: 4
  • TPSA: 145.78
  • ALOGS: -5.76
  • ROTB: 18

Drug dosage:

DoseUnitRoute
1.20 g O
0.80 g O
0.30 g O

Approvals:

DateAgencyCompanyOrphan
March 1, 1996 FDA ABBVIE

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 6322.43 38.89 1597 13662 21572 4602161
Exposure during pregnancy 4743.68 38.89 1374 13885 31597 4592136
Premature baby 2356.01 38.89 618 14641 9433 4614300
Abortion spontaneous 2257.35 38.89 643 14616 13549 4610184
Virologic failure 2131.87 38.89 431 14828 1798 4621935
Drug interaction 1747.44 38.89 784 14475 63724 4560009
Immune reconstitution inflammatory syndrome 1745.12 38.89 386 14873 2668 4621065
Lipodystrophy acquired 1549.39 38.89 280 14979 520 4623213
Maternal exposure during pregnancy 1533.15 38.89 499 14760 16594 4607139
Cushing's syndrome 1042.64 38.89 225 15034 1356 4622377
Stillbirth 977.61 38.89 223 15036 1791 4621942
Abortion induced 952.96 38.89 251 15008 3846 4619887
Drug resistance 924.81 38.89 285 14974 7851 4615882
Premature delivery 919.15 38.89 245 15014 3939 4619794
Live birth 802.91 38.89 180 15079 1323 4622410
Anaemia 726.71 38.89 453 14806 71107 4552626
Hyperbilirubinaemia 724.56 38.89 207 15052 4344 4619389
Acute kidney injury 677.72 38.89 431 14828 70000 4553733
Foetal death 654.23 38.89 169 15090 2383 4621350
Diarrhoea 642.43 38.89 564 14695 149621 4474112
Pyrexia 570.22 38.89 457 14802 106687 4517046
Nephrolithiasis 565.81 38.89 202 15057 8837 4614896
Foetal growth restriction 552.56 38.89 148 15111 2418 4621315
Mitochondrial toxicity 546.30 38.89 101 15158 224 4623509
Congenital anomaly 530.48 38.89 139 15120 2077 4621656
Renal tubular disorder 518.48 38.89 127 15132 1421 4622312
Hepatitis 517.23 38.89 205 15054 12000 4611733
Jaundice 492.12 38.89 199 15060 12275 4611458
Caesarean section 488.90 38.89 157 15102 4941 4618792
Renal colic 488.54 38.89 107 15152 695 4623038
Renal failure 467.70 38.89 281 14978 41088 4582645
Vomiting 458.15 38.89 423 14836 119276 4504457
Viral load increased 452.65 38.89 106 15153 963 4622770
Osteoporosis 436.20 38.89 153 15106 6342 4617391
Kaposi's sarcoma 423.64 38.89 105 15154 1237 4622496
Premature labour 420.54 38.89 117 15142 2215 4621518
Nausea 416.74 38.89 482 14777 176851 4446882
Pregnancy 415.00 38.89 160 15099 8684 4615049
Low birth weight baby 412.05 38.89 119 15140 2591 4621142
Osteonecrosis 391.25 38.89 169 15090 12295 4611438
Ventricular septal defect 391.17 38.89 111 15148 2264 4621469
Alanine aminotransferase increased 390.15 38.89 219 15040 28154 4595579
Hypertriglyceridaemia 383.16 38.89 109 15150 2244 4621489
Progressive external ophthalmoplegia 376.56 38.89 58 15201 5 4623728
Trisomy 21 371.35 38.89 80 15179 475 4623258
Blood bilirubin increased 369.31 38.89 163 15096 12489 4611244
Maternal drugs affecting foetus 367.41 38.89 119 15140 3846 4619887
Polydactyly 363.53 38.89 78 15181 453 4623280
Premature rupture of membranes 348.97 38.89 85 15174 926 4622807
Treatment noncompliance 347.97 38.89 154 15105 11873 4611860
Aspartate aminotransferase increased 333.31 38.89 189 15070 24749 4598984
Viral mutation identified 332.47 38.89 84 15175 1075 4622658
HIV infection 326.03 38.89 73 15186 531 4623202
Eyelid ptosis 317.45 38.89 91 15168 1926 4621807
Renal impairment 311.84 38.89 182 15077 25156 4598577
Fanconi syndrome 309.94 38.89 71 15188 579 4623154
Hyperlipidaemia 306.78 38.89 111 15148 5034 4618699
Hepatotoxicity 298.51 38.89 124 15135 8175 4615558
Pancytopenia 291.33 38.89 173 15086 24680 4599053
Rash 290.23 38.89 316 14943 108072 4515661
Spina bifida 284.34 38.89 63 15196 434 4623299
Thrombocytopenia 284.10 38.89 218 15041 47455 4576278
Blood triglycerides increased 277.31 38.89 104 15155 5221 4618512
Hyperlactacidaemia 277.23 38.89 69 15190 827 4622906
Gastrointestinal disorder 276.47 38.89 144 15115 15917 4607816
Small for dates baby 264.14 38.89 79 15180 1948 4621785
Abdominal pain 262.06 38.89 229 15030 59795 4563938
Weight decreased 256.45 38.89 217 15042 54247 4569486
Mycobacterium avium complex infection 256.00 38.89 64 15195 782 4622951
Cholestasis 253.71 38.89 109 15150 7811 4615922
Lactic acidosis 249.09 38.89 122 15137 11834 4611899
Drug reaction with eosinophilia and systemic symptoms 248.46 38.89 121 15138 11592 4612141
Cardiac murmur 248.05 38.89 83 15176 2972 4620761
Hepatocellular injury 244.12 38.89 106 15153 7794 4615939
CD4 lymphocytes decreased 242.71 38.89 62 15197 831 4622902
Depression 236.69 38.89 196 15063 47537 4576196
Cerebral ventricle dilatation 233.40 38.89 54 15205 462 4623271
Rash maculo-papular 233.14 38.89 105 15154 8424 4615309
Dyslipidaemia 229.04 38.89 68 15191 1633 4622100
Treatment failure 226.86 38.89 121 15138 14026 4609707
Adrenal insufficiency 220.92 38.89 76 15183 2964 4620769
Normal newborn 213.05 38.89 65 15194 1717 4622016
Asthenia 212.72 38.89 241 15018 85922 4537811
Gamma-glutamyltransferase increased 211.25 38.89 107 15152 11147 4612586
Exomphalos 205.61 38.89 43 15216 216 4623517
Oesophageal atresia 205.01 38.89 45 15214 295 4623438
Proteinuria 204.89 38.89 89 15170 6547 4617186
Fanconi syndrome acquired 198.64 38.89 51 15208 698 4623035
Pre-eclampsia 197.30 38.89 60 15199 1567 4622166
Skull malformation 195.75 38.89 43 15216 283 4623450
Diplopia 194.22 38.89 85 15174 6366 4617367
Pancreatitis 191.90 38.89 116 15143 17062 4606671
Adrenal suppression 190.56 38.89 43 15216 325 4623408
Liver disorder 190.43 38.89 105 15154 12993 4610740
Hepatitis C 187.95 38.89 77 15182 4893 4618840
HIV-associated neurocognitive disorder 187.61 38.89 35 15224 83 4623650
Hypercholesterolaemia 187.28 38.89 67 15192 2936 4620797
Patent ductus arteriosus 187.16 38.89 58 15201 1616 4622117
Diabetes mellitus 187.01 38.89 110 15149 15391 4608342
Myocardial infarction 186.99 38.89 174 15085 49202 4574531
Portal hypertension 185.90 38.89 55 15204 1304 4622429
Atrial septal defect 184.75 38.89 69 15190 3420 4620313
Low set ears 184.24 38.89 38 15221 176 4623557
Hepatic cirrhosis 183.70 38.89 78 15181 5424 4618309
Progressive multifocal leukoencephalopathy 183.51 38.89 72 15187 4085 4619648
Ascites 183.24 38.89 100 15159 12125 4611608
Pneumonia 183.20 38.89 244 15015 102571 4521162
General physical health deterioration 183.16 38.89 137 15122 28641 4595092
Pneumocystis jirovecii pneumonia 182.08 38.89 77 15182 5301 4618432
Umbilical cord abnormality 181.02 38.89 38 15221 195 4623538
Eosinophilia 178.19 38.89 82 15177 6911 4616822
Lipohypertrophy 177.39 38.89 37 15222 183 4623550
Cytomegalovirus chorioretinitis 177.09 38.89 46 15213 661 4623072
Hepatic failure 176.42 38.89 100 15159 13049 4610684
Congenital naevus 176.02 38.89 31 15228 45 4623688
Blood creatinine increased 175.52 38.89 130 15129 26770 4596963
Cushingoid 173.75 38.89 50 15209 1072 4622661
Nervous system disorder 172.01 38.89 78 15181 6353 4617380
Neuropathy peripheral 171.75 38.89 122 15137 23547 4600186
Transaminases increased 170.60 38.89 88 15171 9518 4614215
Headache 165.93 38.89 255 15004 122118 4501615
Neutropenia 164.46 38.89 160 15099 47790 4575943
Cerebral toxoplasmosis 162.44 38.89 37 15222 293 4623440
Insomnia 160.57 38.89 154 15105 45191 4578542
Oesophageal candidiasis 157.33 38.89 49 15210 1388 4622345
Oligohydramnios 156.11 38.89 47 15212 1185 4622548
Hepatomegaly 155.77 38.89 62 15197 3653 4620080
Blood lactic acid increased 154.61 38.89 52 15207 1890 4621843
Blood creatine phosphokinase increased 153.43 38.89 96 15163 15003 4608730
Spine malformation 153.18 38.89 31 15228 128 4623605
Meningomyelocele 152.33 38.89 34 15225 243 4623490
Lipoatrophy 151.51 38.89 35 15224 297 4623436
Fatigue 151.17 38.89 269 14990 145297 4478436
Hypokalaemia 150.83 38.89 103 15156 18657 4605076
Hypophosphataemia 149.21 38.89 56 15203 2813 4620920
Abdominal distension 147.56 38.89 100 15159 17889 4605844
Dysmorphism 147.22 38.89 43 15216 973 4622760
Cholelithiasis 146.70 38.89 79 15180 9323 4614410
Gestational diabetes 146.14 38.89 47 15212 1481 4622252
Drug level increased 145.56 38.89 69 15190 6217 4617516
Myalgia 145.45 38.89 141 15118 41907 4581826
Neural tube defect 143.64 38.89 29 15230 118 4623615
Polyhydramnios 141.32 38.89 35 15224 410 4623323
Liver function test abnormal 140.75 38.89 90 15169 14602 4609131
Cloacal exstrophy 139.32 38.89 22 15237 6 4623727
Hypertension 138.79 38.89 150 15109 50648 4573085
Anal atresia 138.59 38.89 31 15228 224 4623509
Death 138.20 38.89 310 14949 197853 4425880
Gastrointestinal disorder congenital 137.36 38.89 23 15236 19 4623714
Metabolic acidosis 136.31 38.89 83 15176 12357 4611376
Acquired immunodeficiency syndrome 136.05 38.89 28 15231 128 4623605
Blood alkaline phosphatase increased 135.90 38.89 83 15176 12424 4611309
Weight increased 134.72 38.89 127 15132 36454 4587279
Calculus urinary 134.53 38.89 35 15224 506 4623227
Cortisol decreased 133.88 38.89 34 15225 444 4623289
Bladder agenesis 133.80 38.89 22 15237 14 4623719
Pruritus 133.35 38.89 175 15084 72397 4551336
Dysphagia 130.89 38.89 107 15152 25424 4598309
Blood HIV RNA increased 130.38 38.89 32 15227 360 4623373
Sepsis 130.36 38.89 134 15125 42705 4581028
Mitochondrial cytopathy 130.21 38.89 27 15232 129 4623604
Hepatic function abnormal 129.84 38.89 85 15174 14351 4609382
Nephropathy toxic 129.17 38.89 56 15203 4096 4619637
Blood bilirubin unconjugated increased 128.82 38.89 31 15228 319 4623414
Hydrocephalus 128.65 38.89 46 15213 2011 4621722
Pathogen resistance 128.61 38.89 50 15209 2766 4620967
Cryptorchism 126.14 38.89 32 15227 416 4623317
Talipes 125.61 38.89 39 15220 1093 4622640
Rhabdomyolysis 124.13 38.89 93 15166 19465 4604268
Ocular icterus 122.40 38.89 40 15219 1327 4622406
Vertigo 122.31 38.89 83 15176 14873 4608860
Cholestasis of pregnancy 122.25 38.89 25 15234 110 4623623
Pancreatitis acute 122.06 38.89 68 15191 8575 4615158
Renal tubular necrosis 121.11 38.89 53 15206 3965 4619768
Tubulointerstitial nephritis 120.13 38.89 60 15199 6059 4617674
Meconium stain 120.11 38.89 23 15236 66 4623667
Hepatic enzyme increased 119.67 38.89 88 15171 17903 4605830
Dehydration 119.21 38.89 127 15132 42163 4581570
Supernumerary nipple 118.13 38.89 20 15239 19 4623714
Oral candidiasis 118.13 38.89 50 15209 3447 4620286
Foetal distress syndrome 117.99 38.89 35 15224 837 4622896
Tethered cord syndrome 117.38 38.89 22 15237 54 4623679
Caudal regression syndrome 115.98 38.89 22 15237 59 4623674
Placenta praevia 115.86 38.89 27 15232 239 4623494
Hyperglycaemia 115.04 38.89 72 15187 11250 4612483
Ergot poisoning 114.67 38.89 22 15237 64 4623669
Genitalia external ambiguous 114.41 38.89 22 15237 65 4623668
Trisomy 18 112.70 38.89 25 15234 173 4623560
Congenital central nervous system anomaly 112.26 38.89 29 15230 407 4623326
Blood cholesterol increased 110.82 38.89 64 15195 8642 4615091
Placental insufficiency 110.15 38.89 27 15232 302 4623431
Glycosuria 110.07 38.89 30 15229 523 4623210
Encephalitis 107.55 38.89 43 15216 2562 4621171
Syphilis 106.37 38.89 23 15236 139 4623594
Atypical mycobacterial infection 106.29 38.89 28 15231 426 4623307
Limb malformation 106.21 38.89 27 15232 354 4623379
Lymphadenopathy 105.36 38.89 66 15193 10326 4613407
Placental disorder 104.31 38.89 27 15232 382 4623351
Congenital musculoskeletal anomaly 104.27 38.89 24 15235 200 4623533
Decreased appetite 101.98 38.89 135 15124 56262 4567471
Malaise 101.68 38.89 173 15086 89984 4533749
CSF HIV escape syndrome 101.55 38.89 17 15242 14 4623719
Hyperuricaemia 101.18 38.89 37 15222 1726 4622007
Congenital hydronephrosis 99.20 38.89 24 15235 253 4623480
Acoustic stimulation tests abnormal 99.10 38.89 19 15240 55 4623678
Hepatic steatosis 99.01 38.89 53 15206 6175 4617558
Alpha 1 foetoprotein abnormal 98.57 38.89 18 15241 36 4623697
Pyelocaliectasis 98.47 38.89 25 15234 326 4623407
Cachexia 97.01 38.89 37 15222 1942 4621791
Congenital genital malformation 96.38 38.89 18 15241 43 4623690
Multiple-drug resistance 95.59 38.89 28 15231 640 4623093
Hyperadrenocorticism 94.72 38.89 20 15239 106 4623627
Heart disease congenital 94.68 38.89 32 15227 1180 4622553
Acute myocardial infarction 94.51 38.89 70 15189 14389 4609344
Toxicity to various agents 94.43 38.89 148 15111 71892 4551841
Gastrointestinal malformation 93.20 38.89 19 15240 82 4623651
Varices oesophageal 92.20 38.89 31 15228 1125 4622608
Foetal heart rate abnormal 91.38 38.89 23 15236 289 4623444
Haemolytic anaemia 91.06 38.89 44 15215 4134 4619599
Hyponatraemia 89.35 38.89 85 15174 24645 4599088
Death neonatal 89.16 38.89 25 15234 486 4623247
Lymphoma 88.36 38.89 45 15214 4733 4619000
Septic shock 87.44 38.89 71 15188 16695 4607038
Face oedema 87.33 38.89 50 15209 6640 4617093
Condition aggravated 86.84 38.89 127 15132 58044 4565689
Pulmonary tuberculosis 86.72 38.89 35 15224 2137 4621596
Toxic skin eruption 86.12 38.89 43 15216 4337 4619396
Cytomegalovirus infection 83.96 38.89 50 15209 7143 4616590
Congenital heart valve disorder 83.84 38.89 17 15242 71 4623662
Hepatosplenomegaly 83.10 38.89 29 15230 1179 4622554
Coronary artery disease 83.02 38.89 68 15191 16184 4607549
Oedema peripheral 82.91 38.89 105 15154 41867 4581866
Cardiac malposition 82.48 38.89 15 15244 29 4623704
Dyspnoea 81.99 38.89 204 15055 138781 4484952
Secondary adrenocortical insufficiency 81.96 38.89 22 15237 361 4623372
Tachypnoea 81.47 38.89 43 15216 4868 4618865
Microcephaly 81.41 38.89 23 15236 460 4623273
Single umbilical artery 81.21 38.89 18 15241 124 4623609
Congenital foot malformation 81.14 38.89 19 15240 172 4623561
Drug-induced liver injury 80.70 38.89 52 15207 8539 4615194
Congenital choroid plexus cyst 80.35 38.89 18 15241 131 4623602
Hodgkin's disease 80.33 38.89 30 15229 1485 4622248
Hydronephrosis 80.28 38.89 36 15223 2853 4620880
Herpes zoster 80.25 38.89 66 15193 15797 4607936
Ultrasound antenatal screen abnormal 79.75 38.89 17 15242 95 4623638
Splenomegaly 79.50 38.89 40 15219 4100 4619633
Leukopenia 79.07 38.89 75 15184 21661 4602072
Multiple organ dysfunction syndrome 78.50 38.89 70 15189 18686 4605047
Hepatitis cholestatic 76.92 38.89 34 15225 2604 4621129
Haematotoxicity 76.87 38.89 36 15223 3153 4620580
Electrocardiogram QT prolonged 76.04 38.89 63 15196 15232 4608501
Encephalopathy 75.91 38.89 53 15206 9934 4613799
Sudden infant death syndrome 75.68 38.89 19 15240 236 4623497
Meningitis cryptococcal 75.09 38.89 23 15236 615 4623118
Amylase increased 73.80 38.89 33 15226 2597 4621136
Diaphragmatic hernia 73.78 38.89 18 15241 197 4623536
Central obesity 73.37 38.89 18 15241 202 4623531
Polyneuropathy 73.07 38.89 37 15222 3844 4619889
Chronic kidney disease 72.87 38.89 53 15206 10592 4613141
Depressed mood 72.09 38.89 49 15210 8795 4614938
Respiratory failure 71.50 38.89 83 15176 30243 4593490
Seizure 71.10 38.89 107 15152 50130 4573603
Myositis 70.91 38.89 34 15225 3139 4620594
Cell death 70.25 38.89 23 15236 767 4622966
Human immunodeficiency virus transmission 69.93 38.89 14 15245 54 4623679
Cough 69.75 38.89 112 15147 55475 4568258
Overdose 69.22 38.89 98 15161 43461 4580272
Hepatic displacement 68.90 38.89 11 15248 4 4623729
Anaemia neonatal 68.18 38.89 17 15242 205 4623528
Foetal arrhythmia 68.10 38.89 15 15244 100 4623633
Retinoblastoma 67.84 38.89 14 15245 65 4623668
Hemivertebra 67.49 38.89 14 15245 67 4623666
Mycobacterial infection 67.04 38.89 21 15238 606 4623127
Anogenital warts 66.62 38.89 18 15241 303 4623430
Suicide attempt 66.61 38.89 67 15192 20775 4602958
Epilepsy 66.54 38.89 48 15211 9470 4614263
Respiratory distress 66.39 38.89 51 15208 11065 4612668
Ectopic pregnancy 66.18 38.89 22 15237 770 4622963
Coarctation of the aorta 65.93 38.89 19 15240 409 4623324
Gastritis 65.88 38.89 45 15214 8141 4615592
Gastroenteritis 65.84 38.89 39 15220 5516 4618217
Hepatitis B 65.80 38.89 31 15228 2752 4620981
Congenital skin dimples 65.41 38.89 14 15245 80 4623653
Pyelonephritis 65.39 38.89 32 15227 3090 4620643
Spinal compression fracture 65.10 38.89 31 15228 2818 4620915
Ear malformation 65.02 38.89 16 15243 182 4623551
Alpha 1 foetoprotein increased 64.94 38.89 17 15242 252 4623481
Drug intolerance 64.23 38.89 67 15192 21679 4602054
Amniotic cavity infection 64.04 38.89 18 15241 353 4623380
Arthralgia 63.37 38.89 134 15125 81860 4541873
Alanine aminotransferase abnormal 63.23 38.89 20 15239 596 4623137
Nodular regenerative hyperplasia 62.55 38.89 17 15242 293 4623440
Foetal heart rate disorder 62.53 38.89 13 15246 63 4623670
Uveitis 62.16 38.89 31 15228 3117 4620616
Prenatal screening test abnormal 62.04 38.89 11 15248 17 4623716
Toxoplasmosis 61.96 38.89 18 15241 399 4623334
Abdominal pain upper 61.79 38.89 83 15176 35032 4588701
Haematuria 61.52 38.89 52 15207 12918 4610815
Congenital aortic anomaly 61.39 38.89 13 15246 70 4623663
Prurigo 60.85 38.89 18 15241 426 4623307
Haemoglobin decreased 60.23 38.89 85 15174 37572 4586161
Candida infection 59.79 38.89 36 15223 5245 4618488
Tuberculosis 59.44 38.89 34 15225 4505 4619228
Congenital renal disorder 59.01 38.89 12 15247 51 4623682
Haemophilic arthropathy 58.98 38.89 11 15248 26 4623707
Anembryonic gestation 58.91 38.89 15 15244 198 4623535
Ophthalmoplegia 58.46 38.89 18 15241 490 4623243
Brain herniation 58.19 38.89 23 15236 1329 4622404
Heterotaxia 57.92 38.89 12 15247 57 4623676
Burkitt's lymphoma 57.01 38.89 15 15244 227 4623506
Spinocerebellar disorder 56.99 38.89 10 15249 14 4623719
Cerebellar hypoplasia 56.77 38.89 12 15247 64 4623669
Enanthema 56.17 38.89 15 15244 241 4623492
Congenital bowing of long bones 56.12 38.89 11 15248 37 4623696
Dizziness 56.09 38.89 144 15115 99727 4524006
CD4 lymphocytes abnormal 55.46 38.89 11 15248 40 4623693
Ventricular hypertrophy 55.45 38.89 23 15236 1506 4622227
Hypotonia 55.08 38.89 30 15229 3616 4620117
CSF test abnormal 54.97 38.89 14 15245 185 4623548
Foetal malnutrition 54.63 38.89 11 15248 44 4623689
Unevaluable event 54.55 38.89 54 15205 16422 4607311
Congenital hydrocephalus 54.49 38.89 14 15245 192 4623541
Lipase increased 54.44 38.89 29 15230 3343 4620390
Foetal chromosome abnormality 54.43 38.89 11 15248 45 4623688
Renal disorder 53.70 38.89 42 15217 9354 4614379
Genotype drug resistance test positive 53.61 38.89 17 15242 511 4623222
Congenital pulmonary valve disorder 53.49 38.89 11 15248 50 4623683
Blood iron decreased 53.47 38.89 24 15235 1905 4621828
Syndactyly 53.33 38.89 15 15244 295 4623438
Hypersensitivity 53.16 38.89 81 15178 38340 4585393
Abdominal hernia 52.83 38.89 20 15239 1028 4622705
Agranulocytosis 52.75 38.89 38 15221 7479 4616254
Hepatic encephalopathy 52.51 38.89 31 15228 4356 4619377
Nephropathy 52.46 38.89 24 15235 1992 4621741
Osteoporotic fracture 52.36 38.89 17 15242 552 4623181
Strabismus 52.34 38.89 19 15240 867 4622866
Placental infarction 52.24 38.89 12 15247 99 4623634
Anencephaly 52.02 38.89 14 15245 232 4623501
Adverse event 51.69 38.89 52 15207 16120 4607613
Anal cancer 51.58 38.89 14 15245 240 4623493
Disturbance in attention 51.37 38.89 43 15216 10538 4613195
Congenital anomaly in offspring 51.23 38.89 11 15248 64 4623669
Left ventricular dilatation 51.21 38.89 12 15247 109 4623624
Skin disorder 51.18 38.89 35 15224 6341 4617392
Skin striae 50.87 38.89 15 15244 351 4623382
Cerebral infarction 50.49 38.89 43 15216 10789 4612944
HIV associated nephropathy 50.34 38.89 9 15250 15 4623718
Stevens-Johnson syndrome 50.20 38.89 39 15220 8600 4615133
Ichthyosis 50.12 38.89 11 15248 72 4623661
Teratogenicity 50.08 38.89 12 15247 121 4623612
Coma 49.99 38.89 53 15206 17466 4606267
Blood corticotrophin decreased 49.81 38.89 12 15247 124 4623609
Ultrasound scan abnormal 49.70 38.89 13 15246 192 4623541
Herpes simplex 49.64 38.89 23 15236 1965 4621768
Cleft palate 49.14 38.89 17 15242 673 4623060
Dermatitis exfoliative 48.79 38.89 26 15233 3000 4620733
Diaphragmatic aplasia 48.71 38.89 8 15251 5 4623728
Congenital mitral valve incompetence 48.18 38.89 10 15249 48 4623685
Vitamin D deficiency 47.98 38.89 23 15236 2122 4621611
Jaundice neonatal 47.78 38.89 16 15243 573 4623160
Erectile dysfunction 47.60 38.89 30 15229 4739 4618994
Neurological symptom 47.59 38.89 22 15237 1870 4621863
Arnold-Chiari malformation 47.56 38.89 13 15246 229 4623504
Breast disorder 47.52 38.89 15 15244 444 4623289
Neonatal respiratory arrest 47.52 38.89 10 15249 52 4623681
Intraventricular haemorrhage 47.48 38.89 19 15240 1134 4622599
Volvulus 47.41 38.89 16 15243 587 4623146
Genital herpes simplex 47.20 38.89 10 15249 54 4623679
Umbilical cord vascular disorder 47.05 38.89 10 15249 55 4623678
Leishmaniasis 47.03 38.89 11 15248 99 4623634
Neonatal disorder 47.02 38.89 17 15242 767 4622966
Adverse drug reaction 46.39 38.89 47 15212 14692 4609041
Liver injury 46.38 38.89 30 15229 4955 4618778
Confusional state 46.33 38.89 87 15172 48747 4574986
C-reactive protein increased 46.18 38.89 44 15215 12768 4610965
Platelet count decreased 45.90 38.89 72 15187 34930 4588803
Gastroschisis 45.77 38.89 12 15247 179 4623554
Drug level decreased 45.72 38.89 23 15236 2356 4621377
Retinal toxicity 45.30 38.89 14 15245 386 4623347
Acute hepatic failure 45.26 38.89 31 15228 5631 4618102
Tachycardia 44.98 38.89 67 15192 31078 4592655
Developmental delay 44.68 38.89 18 15241 1093 4622640
Ureterolithiasis 44.59 38.89 16 15243 706 4623027
Amyotrophy 44.47 38.89 12 15247 201 4623532
Sepsis neonatal 44.42 38.89 13 15246 296 4623437
Portal vein thrombosis 44.41 38.89 19 15240 1344 4622389
Cytogenetic abnormality 44.33 38.89 15 15244 555 4623178
Pulmonary valve sclerosis 44.26 38.89 7 15252 2 4623731
Gestational hypertension 44.17 38.89 14 15245 420 4623313
Renal tubular acidosis 43.42 38.89 16 15243 762 4622971
Cerebral dysgenesis 43.17 38.89 8 15251 18 4623715
Micrognathia 43.15 38.89 12 15247 226 4623507
Musculoskeletal deformity 43.06 38.89 9 15250 45 4623688
Neonatal respiratory distress syndrome 43.03 38.89 20 15239 1721 4622012
Fibrous histiocytoma 43.00 38.89 11 15248 148 4623585
Blood phosphorus decreased 42.97 38.89 18 15241 1208 4622525
Congenital hearing disorder 42.89 38.89 9 15250 46 4623687
Dermatitis exfoliative generalised 42.80 38.89 16 15243 794 4622939
Intestinal malrotation 42.76 38.89 10 15249 90 4623643
Blood antidiuretic hormone increased 42.73 38.89 9 15250 47 4623686
Suicidal ideation 42.59 38.89 54 15205 21529 4602204
Cerebral haemorrhage 42.55 38.89 43 15216 13398 4610335
Osteomalacia 42.13 38.89 15 15244 647 4623086
Neonatal hyponatraemia 42.11 38.89 9 15250 51 4623682
Porphyria non-acute 42.10 38.89 12 15247 248 4623485
Hyperkalaemia 41.83 38.89 46 15213 15791 4607942
Parkinsonism 41.75 38.89 24 15235 3209 4620524
Back pain 41.75 38.89 85 15174 50514 4573219
Bone marrow toxicity 41.72 38.89 16 15243 852 4622881
Mental disorder 41.59 38.89 33 15226 7501 4616232
Vanishing bile duct syndrome 41.57 38.89 13 15246 373 4623360
Premature separation of placenta 41.22 38.89 14 15245 524 4623209
Drug eruption 40.97 38.89 31 15228 6572 4617161
Pneumococcal sepsis 40.93 38.89 12 15247 275 4623458
Bone marrow failure 40.78 38.89 41 15218 12697 4611036
Bradycardia 40.68 38.89 54 15205 22515 4601218
Opportunistic infection 40.66 38.89 16 15243 913 4622820
Psychiatric decompensation 40.45 38.89 14 15245 555 4623178
Osteopenia 40.38 38.89 22 15237 2652 4621081
Chills 40.16 38.89 61 15198 28778 4594955
Renal aplasia 40.05 38.89 12 15247 297 4623436
Oropharyngeal candidiasis 40.05 38.89 12 15247 297 4623436
Hypotension 39.69 38.89 99 15160 67301 4556432
Aspartate aminotransferase abnormal 39.52 38.89 13 15246 440 4623293
Anuria 39.43 38.89 25 15234 3990 4619743
Twin pregnancy 39.38 38.89 12 15247 315 4623418
Genital herpes 39.21 38.89 13 15246 451 4623282
Blood lactate dehydrogenase increased 39.20 38.89 32 15227 7571 4616162
Dyschromatopsia 39.13 38.89 10 15249 134 4623599
Staphylococcal infection 39.08 38.89 37 15222 10651 4613082
Pneumonia pneumococcal 38.99 38.89 14 15245 619 4623114

Pharmacologic Action:

SourceCodeDescription
ATC J05AE03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Protease inhibitors
ATC J05AP52 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HCV infections
ATC J05AP53 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HCV infections
ATC J05AR10 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HIV infections, combinations
ATC J05AR23 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HIV infections, combinations
ATC J05AR26 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Antivirals for treatment of HIV infections, combinations
FDA EPC N0000191001 Cytochrome P450 3A Inhibitor
FDA EPC N0000175889 Protease Inhibitor
FDA MoA N0000190114 Cytochrome P450 3A Inhibitors
FDA MoA N0000182137 Cytochrome P450 2D6 Inhibitors
FDA MoA N0000185607 Cytochrome P450 2C19 Inducers
FDA MoA N0000190118 Cytochrome P450 3A Inducers
FDA MoA N0000185503 P-Glycoprotein Inhibitors
FDA MoA N0000190113 Breast Cancer Resistance Protein Inhibitors
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000191266 Cytochrome P450 1A2 Inducers
FDA MoA N0000185507 Cytochrome P450 2C9 Inducers
FDA MoA N0000187064 Cytochrome P450 2B6 Inducers
FDA MoA N0000190117 UDP Glucuronosyltransferases Inducers
MeSH PA D019380 Anti-HIV Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D044966 Anti-Retroviral Agents
MeSH PA D000998 Antiviral Agents
MeSH PA D065692 Cytochrome P-450 CYP3A Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D017320 HIV Protease Inhibitors
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:36044 antiviral drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Human immunodeficiency virus infection indication 86406008 DOID:526
Chronic hepatitis C indication 128302006
Coronavirus infection off-label use 186747009
Prevention of HIV Infection after Exposure off-label use
Hypercholesterolemia contraindication 13644009
Hyperbilirubinemia contraindication 14783006 DOID:2741
Cirrhosis of liver contraindication 19943007 DOID:5082
Complete atrioventricular block contraindication 27885002
Hereditary factor VIII deficiency disease contraindication 28293008 DOID:12134
Torsades de pointes contraindication 31722008
Hyperuricemia contraindication 35885006 DOID:1920
Hereditary factor IX deficiency disease contraindication 41788008 DOID:12259
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic type B viral hepatitis contraindication 61977001
Diabetes mellitus contraindication 73211009 DOID:9351
Pancreatitis contraindication 75694006 DOID:4989
Hyperglycemia contraindication 80394007 DOID:4195
Cardiomyopathy contraindication 85898001 DOID:0050700
Gout contraindication 90560007 DOID:13189
Prolonged QT interval contraindication 111975006
Structural disorder of heart contraindication 128599005
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Mixed hyperlipidemia contraindication 267434003
Hypertriglyceridemia contraindication 302870006
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Congenital long QT syndrome contraindication 442917000
First Degree Atrioventricular Heart Block contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.39 acidic
pKa2 13.84 acidic
pKa3 3.62 Basic
pKa4 2.45 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 8501238 Sept. 17, 2028 USE OF DASABUVIR TO INHIBIT VIRAL REPLICATION FOR THE TREATMENT OF HCV INFECTION.
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 8501238 Sept. 17, 2028 USE OF DASABUVIR TO INHIBIT VIRAL REPLICATION FOR THE TREATMENT OF HCV INFECTION.
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 9139536 Nov. 9, 2028 TREATMENT OF HCV INFECTION USING DASABUVIR
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 9139536 Nov. 9, 2028 TREATMENT OF HCV INFECTION USING DASABUVIR
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 8188104 May 17, 2029 USE OF DASABUVIR TO INHIBIT VIRAL REPLICATION FOR THE TREATMENT OF HCV INFECTION.
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 8188104 May 17, 2029 USE OF DASABUVIR TO INHIBIT VIRAL REPLICATION FOR THE TREATMENT OF HCV INFECTION.
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 8642538 Sept. 10, 2029 TREATMENT OF HCV INFECTION USING PARITAPREVIR
50MG TECHNIVIE ABBVIE INC N207931 July 24, 2015 DISCN TABLET ORAL 8642538 Sept. 10, 2029 TREATMENT OF HCV INFECTION USING PARITAPREVIR
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 8642538 Sept. 10, 2029 TREATMENT OF HCV INFECTION USING PARITAPREVIR
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 9006387 June 10, 2030 TREATMENT OF HCV INFECTION USING OMBITASVIR
50MG TECHNIVIE ABBVIE INC N207931 July 24, 2015 DISCN TABLET ORAL 9006387 June 10, 2030 TREATMENT OF HCV INFECTION USING OMBITASVIR
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 9006387 June 10, 2030 TREATMENT OF HCV INFECTION USING OMBITASVIR
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 9044480 April 10, 2031 TREATMENT OF HCV INFECTION USING PARITAPREVIR
50MG TECHNIVIE ABBVIE INC N207931 July 24, 2015 DISCN TABLET ORAL 9044480 April 10, 2031 TREATMENT OF HCV INFECTION USING PARITAPREVIR
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 9044480 April 10, 2031 TREATMENT OF HCV INFECTION USING PARITAPREVIR
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 10201584 May 17, 2032 TREATMENT OF HCV INFECTION USING DASABUVIR/OMBITASVIR/PARITAPREVIR/RITONAVIR FIXED DOSE COMBINATION
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 8466159 Sept. 4, 2032 TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR WITH RIBAVIRIN.
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 8492386 Sept. 4, 2032 TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR, WITHOUT RIBAVIRIN
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 8680106 Sept. 4, 2032 TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR WITH RIBAVIRIN.
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 8685984 Sept. 4, 2032 TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR, WITHOUT RIBAVIRIN
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 8466159 Sept. 4, 2032 TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR WITH RIBAVIRIN.
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 8492386 Sept. 4, 2032 TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR, WITHOUT RIBAVIRIN
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 8680106 Sept. 4, 2032 TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR WITH RIBAVIRIN.
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 8685984 Sept. 4, 2032 TREATMENT OF HCV INFECTION USING PARITAPREVIR, OMBITASVIR, RITONAVIR, AND DASABUVIR, WITHOUT RIBAVIRIN
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 10201542 Oct. 18, 2033 TREATMENT OF HCV INFECTION USING DASABUVIR
None VIEKIRA PAK (COPACKAGED) ABBVIE INC N206619 Dec. 19, 2014 RX TABLET, TABLET ORAL 9629841 Oct. 18, 2033 TREATMENT OF HCV INFECTION USING DASABUVIR
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 10105365 Jan. 2, 2035 TREATMENT OF HCV INFECTION USING DASABUVIR/OMBITASVIR/PARITAPREVIR/RITONAVIR FIXED DOSE COMBINATION
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 9333204 Jan. 2, 2035 TREATMENT OF HCV INFECTION USING DASABUVIR/OMBITASVIR/PARITAPREVIR/RITONAVIR FIXED DOSE COMBINATION
33.33MG VIEKIRA XR ABBVIE INC N208624 July 22, 2016 DISCN TABLET, EXTENDED RELEASE ORAL 9744170 Jan. 2, 2035 TREATMENT OF HCV INFECTION USING DASABUVIR/OMBITASVIR/PARITAPREVIR/RITONAVIR FIXED DOSE COMBINATION

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 2D6 Enzyme IC50 4.30 DRUG MATRIX
Kappa-type opioid receptor GPCR Ki 5.26 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 7.80 DRUG MATRIX
Vasopressin V1a receptor GPCR Ki 5.30 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 7.12 DRUG MATRIX
Substance-K receptor GPCR Ki 6.06 DRUG MATRIX
Cytochrome P450 3A4 Enzyme IC50 7.55 WOMBAT-PK
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor WOMBAT-PK
Multidrug resistance protein 1 Transporter IC50 5.83 WOMBAT-PK
Solute carrier family 22 member 1 Transporter IC50 4.47 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 4.61 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 5.36 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 7.10 CHEMBL
Mu-type opioid receptor GPCR Ki 4.58 DRUG MATRIX
Pol polyprotein Enzyme INHIBITOR Ki 10.82 CHEMBL CHEMBL
Gag-Pol polyprotein Polyprotein Ki 9.23 WOMBAT-PK
Protease Enzyme Ki 10.47 CHEMBL

External reference:

IDSource
4020963 VUID
N0000148436 NUI
C0292818 UMLSCUI
D00427 KEGG_DRUG
108693005 SNOMEDCT_US
4020963 VANDF
005554 NDDF
85762 RXNORM
386896009 SNOMEDCT_US
5431 MMSL
d03984 MMSL
251788 MMSL
CHEMBL163 ChEMBL_ID
DB00503 DRUGBANK_ID
O3J8G9O825 UNII
7449 INN_ID
RIT PDB_CHEM_ID
CHEBI:45409 CHEBI
D019438 MESH_DESCRIPTOR_UI
392622 PUBCHEM_CID
8804 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ritonavir HUMAN PRESCRIPTION DRUG LABEL 1 0054-0407 TABLET, FILM COATED 100 mg ORAL ANDA 20 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 0074-0522 TABLET, FILM COATED 25 mg ORAL NDA 18 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 0074-1575 TABLET, FILM COATED 25 mg ORAL NDA 18 sections
Norvir HUMAN PRESCRIPTION DRUG LABEL 1 0074-1940 SOLUTION 80 mg ORAL NDA 21 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 0074-2605 TABLET, FILM COATED 50 mg ORAL NDA 18 sections
Viekira Pak HUMAN PRESCRIPTION DRUG LABEL 4 0074-3093 KIT 50 mg None NDA 19 sections
Norvir HUMAN PRESCRIPTION DRUG LABEL 1 0074-3333 TABLET, FILM COATED 100 mg ORAL NDA 21 sections
Norvir HUMAN PRESCRIPTION DRUG LABEL 1 0074-3399 POWDER 100 mg ORAL NDA 21 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 0074-3956 SOLUTION 20 mg ORAL NDA 18 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 0074-6799 TABLET, FILM COATED 50 mg ORAL NDA 18 sections
Lopinavir-Ritonavir HUMAN PRESCRIPTION DRUG LABEL 2 0527-1947 SOLUTION 20 mg ORAL ANDA 19 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 11819-342 TABLET, FILM COATED 50 mg ORAL NDA 18 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 21695-362 TABLET, FILM COATED 50 mg ORAL NDA 18 sections
Ritonavir HUMAN PRESCRIPTION DRUG LABEL 1 31722-597 TABLET 100 mg ORAL ANDA 20 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 53808-0276 TABLET, FILM COATED 50 mg ORAL NDA 18 sections
Norvir HUMAN PRESCRIPTION DRUG LABEL 1 53808-1119 TABLET, FILM COATED 100 mg ORAL NDA 20 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 54868-5566 TABLET, FILM COATED 50 mg ORAL NDA 18 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 55289-947 TABLET, FILM COATED 50 mg ORAL NDA 18 sections
Ritonavir HUMAN PRESCRIPTION DRUG LABEL 1 60687-364 TABLET, FILM COATED 100 mg ORAL ANDA 21 sections
Ritonavir HUMAN PRESCRIPTION DRUG LABEL 1 60687-420 TABLET, FILM COATED 100 mg ORAL ANDA 21 sections
Lopinavir and Ritonavir HUMAN PRESCRIPTION DRUG LABEL 2 65015-299 GRANULE 10 mg ORAL Export only 1 sections
Ritonavir HUMAN PRESCRIPTION DRUG LABEL 1 65162-061 TABLET 100 mg ORAL ANDA 20 sections
Ritonavir HUMAN PRESCRIPTION DRUG LABEL 1 65862-687 TABLET, FILM COATED 100 mg ORAL ANDA 20 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 66336-624 TABLET, FILM COATED 50 mg ORAL NDA 18 sections
Norvir HUMAN PRESCRIPTION DRUG LABEL 1 67296-1234 TABLET, FILM COATED 100 mg ORAL NDA 19 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 68258-1972 TABLET, FILM COATED 50 mg ORAL NDA 18 sections
Kaletra HUMAN PRESCRIPTION DRUG LABEL 2 70518-0091 TABLET, FILM COATED 50 mg ORAL NDA 18 sections
Ritonavir HUMAN PRESCRIPTION DRUG LABEL 1 70518-1086 TABLET, FILM COATED 100 mg ORAL ANDA 19 sections
Ritonavir HUMAN PRESCRIPTION DRUG LABEL 1 70518-1519 TABLET 100 mg ORAL ANDA 20 sections
Ritonavir HUMAN PRESCRIPTION DRUG LABEL 1 70518-2007 TABLET, FILM COATED 100 mg ORAL ANDA 20 sections