rimexolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids not used as glucocorticosteroids | 2384 | 49697-38-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Rimexolone is a corticosteroids indicated for the treatment of postoperative inflammation following ocular surgery and in the treatment of anterior uveitis. Corticosteroids suppress the inflammatory response to a variety of inciting agents of a mechanical, chemical, or immunological nature. They inhibit edema, cellular infiltration, capillary dilatation, fibroblastic proliferation, deposition of collagen and scar formation associated with inflammation. Placebo-controlled clinical studies demonstrated that rimexolone ophthalmic suspension is efficacious for the treatment of anterior chamber inflammation following cataract surgery.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 20 | mg | P |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 30, 1994 | FDA | ALCON |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | H02AB12 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Glucocorticoids |
| ATC | S01BA13 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Uveitis | indication | 128473001 | DOID:13141 |
| Post-Op Ocular Inflammation | indication | ||
| Herpes simplex keratitis | contraindication | 9389005 | |
| Herpes simplex dendritic keratitis | contraindication | 29943008 | |
| Fungal infection of eye | contraindication | 31194008 | |
| Tuberculosis of eye | contraindication | 49107007 | |
| Viral eye infection | contraindication | 312132001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.37 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020899 | VUID |
| N0000148392 | NUI |
| D05729 | KEGG_DRUG |
| 4020899 | VANDF |
| C0140594 | UMLSCUI |
| CHEBI:135566 | CHEBI |
| CHEMBL1200617 | ChEMBL_ID |
| DB00896 | DRUGBANK_ID |
| C013769 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5311412 | PUBCHEM_CID |
| 7099 | IUPHAR_LIGAND_ID |
| 4313 | INN_ID |
| O7M2E4264D | UNII |
| 55681 | RXNORM |
| 5427 | MMSL |
| 005059 | NDDF |
| 108852004 | SNOMEDCT_US |
| 387046003 | SNOMEDCT_US |
Pharmaceutical products:
None