arbutamine indications/contra

Stem definitionDrug idCAS RN
237 128470-16-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • genesa
  • arbutamine
  • arbutamine hydrochloride
  • arbutamine HCl
  • Molecular weight: 317.39
  • Formula: C18H23NO4
  • CLOGP: 1.65
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 5
  • TPSA: 92.95
  • ALOGS: -3.58
  • ROTB: 8

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 12, 1997 FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C01CA22 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000318 Adrenergic beta-Agonists
CHEBI has role CHEBI:35522 beta-adrenergic agonist
CHEBI has role CHEBI:38147 cardiotonic drug
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D020011 Protective Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Cardiac Function Studies indication
Tachyarrhythmia contraindication 6285003
Cardiac pacemaker, device contraindication 14106009
Hyperthyroidism contraindication 34486009 DOID:7998
Chronic heart failure contraindication 48447003
Supraventricular arrhythmia contraindication 72654001
Idiopathic hypertrophic subaortic stenosis contraindication 360465008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Acute coronary syndrome contraindication 394659003
Hypertensive urgency contraindication 443482000

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.97 acidic
pKa2 10.65 acidic
pKa3 12.82 acidic
pKa4 13.76 acidic
pKa5 8.7 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR AGONIST SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

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IDSource
4024125 VUID
N0000022130 NUI
C0172021 UMLSCUI
D02976 KEGG_DRUG
DB01102 DRUGBANK_ID
4024125 VANDF
N0000022130 NDFRT
N0000006927 NDFRT
d04216 MMSL
61609 RXNORM
006945 NDDF
B07L15YAEV UNII
6757 INN_ID
60789 PUBCHEM_CID
CHEMBL1200385 ChEMBL_ID
CHEMBL1201251 ChEMBL_ID
C076559 MESH_SUPPLEMENTAL_RECORD_UI
125251-66-3 SECONDARY_CAS_RN
CHEBI:50580 CHEBI

Pharmaceutical products:

None