ramosetron 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| serotonin receptor antagonists (5-HT3) | 2357 | 132036-88-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 2.65 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 7.03 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.94 hours | Lombardo F, Berellini G, Obach RS |
| BA (Bioavailability) | 0.56 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 10, 1996 | PMDA | Astellas |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Platelet count decreased | 60.61 | 39.79 | 36 | 1065 | 194628 | 79548659 |
| White blood cell count decreased | 53.88 | 39.79 | 33 | 1068 | 188255 | 79555032 |
| Neutrophil count decreased | 47.56 | 39.79 | 24 | 1077 | 93935 | 79649352 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000932 | Antiemetics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018490 | Serotonin Agents |
| MeSH PA | D012702 | Serotonin Antagonists |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Irritable bowel syndrome with diarrhea | indication | 197125005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.88 | acidic |
| pKa2 | 5.69 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 3A | Ion channel | ANTAGONIST | Ki | 10.22 | CHEMBL | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| D02016 | KEGG_DRUG |
| C0526950 | UMLSCUI |
| CHEBI:32088 | CHEBI |
| CHEMBL1643895 | ChEMBL_ID |
| CHEMBL3181841 | ChEMBL_ID |
| DB09290 | DRUGBANK_ID |
| C071315 | MESH_SUPPLEMENTAL_RECORD_UI |
| 108000 | PUBCHEM_CID |
| 2301 | IUPHAR_LIGAND_ID |
| 7161 | INN_ID |
| 132907-72-3 | SECONDARY_CAS_RN |
| 7ZRO0SC54Y | UNII |
| 010967 | NDDF |
| 010968 | NDDF |
Pharmaceutical products:
None