ramatroban Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
thromboxane A2-receptor antagonists; antithrombotic agents 2354 116649-85-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ramatroban
  • baynas
thromboxane A2 receptor antagonist; BAY u 3405 & 3406 are enantiomers of each other
  • Molecular weight: 416.47
  • Formula: C21H21FN2O4S
  • CLOGP: 3.97
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 88.40
  • ALOGS: -4.26
  • ROTB: 5

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D006401 Hematologic Agents
MeSH PA D010975 Platelet Aggregation Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Allergic rhinitis indication 61582004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.2 acidic
pKa2 9.56 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thromboxane A2 receptor GPCR INVERSE AGONIST Ki 9.24 CHEMBL KEGG DRUG
Prostaglandin D2 receptor GPCR Ki 4.96 CHEMBL
Prostaglandin D2 receptor 2 GPCR Ki 8.37 CHEMBL
Prostaglandin D2 receptor 2 Unclassified ANTAGONIST IC50 7.30 IUPHAR
Prostaglandin D2 receptor 2 Unclassified ANTAGONIST Ki 7.30 IUPHAR

External reference:

IDSource
D01128 KEGG_DRUG
CHEMBL361812 ChEMBL_ID
P1ALI72U6C UNII
7273 INN_ID
A8X PDB_CHEM_ID
CHEBI:32087 CHEBI
C063119 MESH_SUPPLEMENTAL_RECORD_UI
DB13036 DRUGBANK_ID
123879 PUBCHEM_CID
1911 IUPHAR_LIGAND_ID

Pharmaceutical products:

None