quinapril Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 2340 85441-61-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • quinapril
  • ectren
  • koretic
  • quinapril hydrochloride
  • quinapril HCl
  • Molecular weight: 438.52
  • Formula: C25H30N2O5
  • CLOGP: 1.74
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 95.94
  • ALOGS: -4.71
  • ROTB: 10

Drug dosage:

DoseUnitRoute
15 mg O
15 mg P

Approvals:

DateAgencyCompanyOrphan
Nov. 19, 1991 FDA PFIZER PHARMS

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 371.29 31.45 105 672 35575 3349507
Angioedema 204.11 31.45 55 722 15080 3370002
Hypotension 98.91 31.45 43 734 49471 3335611
Swollen tongue 92.42 31.45 25 752 6818 3378264
Blood pressure inadequately controlled 88.74 31.45 18 759 1402 3383680
Hyperkalaemia 84.26 31.45 26 751 11268 3373814
Blood pressure increased 74.23 31.45 28 749 22202 3362880
Dizziness 72.62 31.45 40 737 76472 3308610
Hypertension 68.85 31.45 31 746 38435 3346647
Cough 64.65 31.45 30 747 39828 3345254
Acute kidney injury 64.25 31.45 32 745 49651 3335431
Dyspnoea 54.30 31.45 37 740 102897 3282185
Drug interaction 54.19 31.45 28 749 46784 3338298
Orthostatic hypotension 52.32 31.45 15 762 5021 3380061
Toxicity to various agents 51.18 31.45 27 750 47027 3338055
Nausea 46.64 31.45 37 740 129608 3255474
Drug ineffective 45.79 31.45 35 742 116055 3269027
Hyponatraemia 43.23 31.45 18 759 18341 3366741
Condition aggravated 41.16 31.45 22 755 39211 3345871
Balance disorder 39.01 31.45 15 762 12424 3372658
Lactic acidosis 38.40 31.45 13 764 7487 3377595
Product quality issue 36.75 31.45 18 759 26717 3358365
Hypersensitivity 36.02 31.45 18 759 27882 3357200
Blood glucose increased 35.94 31.45 16 761 19139 3365943
Diabetes mellitus inadequate control 35.90 31.45 10 767 3009 3382073
Bartter's syndrome 35.34 31.45 5 772 41 3385041
Bradycardia 34.76 31.45 15 762 16654 3368428
Headache 34.57 31.45 27 750 91953 3293129
Product substitution issue 34.34 31.45 12 765 7588 3377494
Medication residue present 34.22 31.45 9 768 2184 3382898
Diarrhoea 31.57 31.45 27 750 104321 3280761
Syncope 31.50 31.45 16 761 25617 3359465

Pharmacologic Action:

SourceCodeDescription
ATC C09AA06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
FDA EPC N0000175562 Angiotensin Converting Enzyme Inhibitor
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:35457 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Atrial fibrillation off-label use 49436004 DOID:0060224
Diabetic renal disease off-label use 127013003
Acute scleroderma renal crisis off-label use 236503001
Diastolic heart failure off-label use 418304008 DOID:9775
Nondiabetic Proteinuric Nephropathy off-label use
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Acute cerebrovascular insufficiency contraindication 29322000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:2527
Disorder of connective tissue contraindication 105969002 DOID:65
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Myocardial ischemia contraindication 414795007 DOID:3393
Azotemia contraindication 445009001
Hemodialysis with High-Flux Membrane contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.96 acidic
pKa2 5.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 8.08 CHEMBL CHEMBL
Angiotensin-converting enzyme Enzyme IC50 5.40 DRUG MATRIX

External reference:

IDSource
4020549 VUID
N0000148256 NUI
C0072857 UMLSCUI
6350 IUPHAR_LIGAND_ID
D00459 KEGG_DRUG
33067B3N2M UNII
82586-55-8 SECONDARY_CAS_RN
6356 INN_ID
DB00881 DRUGBANK_ID
4020549 VANDF
N0000006736 NDFRT
N0000148256 NDFRT
003612 NDDF
d00365 MMSL
35208 RXNORM
108578004 SNOMEDCT_US
386874003 SNOMEDCT_US
54892 PUBCHEM_CID
CHEMBL1592 ChEMBL_ID
CHEMBL1733 ChEMBL_ID
CHEMBL1201011 ChEMBL_ID
C041125 MESH_SUPPLEMENTAL_RECORD_UI
C054501 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:8713 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 21695-393 TABLET 5 mg ORAL ANDA 12 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 21695-394 TABLET 10 mg ORAL ANDA 12 sections
Quinapril Hydrochloride and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 54868-1802 TABLET, FILM COATED 10 mg ORAL ANDA 13 sections
Quinapril Hydrochloride and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 54868-2847 TABLET, FILM COATED 20 nmol ORAL ANDA 13 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 54868-5241 TABLET, FILM COATED 20 mg ORAL ANDA 13 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 54868-5245 TABLET, FILM COATED 10 mg ORAL ANDA 13 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 54868-5246 TABLET, FILM COATED 40 mg ORAL ANDA 13 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 54868-5279 TABLET, FILM COATED 5 mg ORAL ANDA 13 sections
Quinapril Hydrochloride and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 54868-5475 TABLET, FILM COATED 20 mg ORAL ANDA 13 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 55111-621 TABLET 5 mg ORAL ANDA 12 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 55111-622 TABLET 10 mg ORAL ANDA 12 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 55111-623 TABLET 20 mg ORAL ANDA 12 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 55111-624 TABLET 40 mg ORAL ANDA 12 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 62756-310 TABLET, FILM COATED 5 mg ORAL ANDA 12 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 62756-311 TABLET, FILM COATED 10 mg ORAL ANDA 12 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 62756-312 TABLET, FILM COATED 20 mg ORAL ANDA 12 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 62756-313 TABLET, FILM COATED 40 mg ORAL ANDA 12 sections
Quinapril HUMAN PRESCRIPTION DRUG LABEL 1 63629-1241 TABLET, FILM COATED 20 mg ORAL ANDA 11 sections
Quinapril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 68151-1020 TABLET, FILM COATED 5 mg ORAL NDA AUTHORIZED GENERIC 12 sections
Quinapril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 68151-1021 TABLET, FILM COATED 10 mg ORAL NDA AUTHORIZED GENERIC 12 sections
Quinapril Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 68151-1022 TABLET, FILM COATED 20 mg ORAL NDA AUTHORIZED GENERIC 12 sections