quinagolide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
dopamine receptor agonists, ergoline derivatives	2339	87056-78-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

quinagolide
norprolac

Molecular weight: 395.56
Formula: C20H33N3O3S
CLOGP: 3.73
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 72.88
ALOGS: -3.41
ROTB: 5

Drug dosage:

Dose	Unit	Route
75	mcg	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	99 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G02CB04	GENITO URINARY SYSTEM AND SEX HORMONES OTHER GYNECOLOGICALS OTHER GYNECOLOGICALS Prolactine inhibitors
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018491	Dopamine Agonists
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.45	acidic
pKa2	11.15	acidic
pKa3	8.35	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Serotonin (5-HT) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT1A_RAT 5HT1B_RAT 5HT1D_RAT 5HT1F_RAT 5HT2B_RAT 5HT6R_RAT 5HT7R_RAT 5HT5A_RAT 5HT5B_RAT 5HT3A_RAT 5HT4R_RAT 5HT3B_RAT		IC50	5.64		CHEMBL
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		IC50	5.25		CHEMBL
Dopamine receptor	GPCR		DRD2_BOVIN DRD1_BOVIN		IC50	7.72		CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		IC50	5.22		CHEMBL

External reference:

ID	Source
D07217	KEGG_DRUG
C0256089	UMLSCUI
CHEBI:135627	CHEBI
CHEMBL2218861	ChEMBL_ID
CHEMBL290962	ChEMBL_ID
DB09097	DRUGBANK_ID
C046650	MESH_SUPPLEMENTAL_RECORD_UI
3086400	PUBCHEM_CID
6545	INN_ID
80Q9QWN15M	UNII
152131	RXNORM
005470	NDDF
326066005	SNOMEDCT_US
395850005	SNOMEDCT_US

Pharmaceutical products:

None