proxyphylline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
N-methylated xanthine derivatives 2323 603-00-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • proxyphylline
  • hydroxypropyltheophylline
  • monophylline
  • oxypropyltheophylline
  • proxiphylline
  • purophyllin
  • beta-Hydroxypropyltheophylline
  • Molecular weight: 238.25
  • Formula: C10H14N4O3
  • CLOGP: -0.56
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 78.67
  • ALOGS: -1.21
  • ROTB: 2

Drug dosage:

DoseUnitRoute
1.20 g O
1.20 g P
1.20 g R

ADMET properties:

PropertyValueReference
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.59 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.17 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.80 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03DA03 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines
ATC R03DB03 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines and adrenergics
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01771 KEGG_DRUG
C0072511 UMLSCUI
CHEBI:32070 CHEBI
CHEMBL37019 ChEMBL_ID
CHEMBL37390 ChEMBL_ID
CHEMBL290644 ChEMBL_ID
DB13449 DRUGBANK_ID
4977 PUBCHEM_CID
C003237 MESH_SUPPLEMENTAL_RECORD_UI
969 INN_ID
13G1DMN4P0 UNII
34906 RXNORM
006056 NDDF

Pharmaceutical products:

None