aprobarbital indications/contra

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 232 77-02-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aprobarbital
  • allonal
  • allylisopropylbarbituric acid
  • allylisopropylmalonylurea
  • allylpropymal
  • allypropymal
  • aprobarbitone
  • isopropylallylbarbituric acid
  • Molecular weight: 210.23
  • Formula: C10H14N2O3
  • CLOGP: 1.10
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.27
  • ALOGS: -1.61
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.10 g O
0.10 g P

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N05CA05 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Barbiturates, plain

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Severe anxiety (panic) indication 80583007
Insomnia indication 193462001

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.05 acidic
pKa2 9.75 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
4017804 VUID
N0000179035 NUI
C0051241 UMLSCUI
CHEMBL7863 ChEMBL_ID
6464 PUBCHEM_CID
4017804 VANDF
17381 RXNORM
N0000179035 NDFRT
N0000146165 NDFRT
398724001 SNOMEDCT_US
80532007 SNOMEDCT_US
001418 NDDF
CHEBI:2791 CHEBI
C006470 MESH_SUPPLEMENTAL_RECORD_UI
DB01352 DRUGBANK_ID
Q0YKG9L6RF UNII
1161 INN_ID

Pharmaceutical products:

None