prothipendyl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vasodilators 2315 303-69-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prothipendyl hydrochloride
  • prothipendyl
  • phrenotropin
  • dominal
  • prothipendyl HCl
a neuroleptic azaphenothiazine; RN given refers to parent cpd
  • Molecular weight: 285.41
  • Formula: C16H19N3S
  • CLOGP: 4.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 19.37
  • ALOGS: -3.35
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.24 g O
0.24 g P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 63.99 56.94 35 592 229096 63259299
Skin maceration 60.24 56.94 7 620 41 63488354

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Labelled drug-drug interaction medication error 56.59 45.77 18 670 14921 34941322

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Labelled drug-drug interaction medication error 101.20 37.72 30 1090 27620 79715648
Disorientation 66.58 37.72 27 1093 62749 79680519
Drug interaction 66.36 37.72 51 1069 415132 79328136
Skin maceration 54.45 37.72 7 1113 70 79743198
General physical health deterioration 53.24 37.72 38 1082 275200 79468068
Helplessness 50.70 37.72 8 1112 364 79742904
Restlessness 45.85 37.72 19 1101 46473 79696795
Product prescribing error 43.13 37.72 18 1102 44795 79698473
Delirium 37.81 37.72 20 1100 84607 79658661

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AX07 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Other antipsychotics

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.01 Basic
pKa2 2.74 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07313 KEGG_DRUG
1225-65-6 SECONDARY_CAS_RN
C0139007 UMLSCUI
CHEBI:135182 CHEBI
CHEMBL2111030 ChEMBL_ID
CHEMBL2107124 ChEMBL_ID
DB12958 DRUGBANK_ID
C069248 MESH_SUPPLEMENTAL_RECORD_UI
14670 PUBCHEM_CID
691 INN_ID
5O6VWA87VA UNII
236710 RXNORM
006649 NDDF
006650 NDDF
27766008 SNOMEDCT_US

Pharmaceutical products:

None