proparacaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| local anaesthetics | 2294 | 499-67-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 1, 1953 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Retinopathy of prematurity | 179.28 | 89.61 | 23 | 605 | 336 | 63488058 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Conjunctival hyperaemia | 228.48 | 127.81 | 41 | 815 | 2361 | 34953714 |
| Hypopyon | 227.87 | 127.81 | 32 | 824 | 364 | 34955711 |
| Corneal epithelium defect | 188.78 | 127.81 | 27 | 829 | 352 | 34955723 |
| Corneal oedema | 188.62 | 127.81 | 32 | 824 | 1319 | 34954756 |
| Ulcerative keratitis | 180.74 | 127.81 | 32 | 824 | 1697 | 34954378 |
| Eye pain | 134.04 | 127.81 | 36 | 820 | 13426 | 34942649 |
| Corneal infiltrates | 133.87 | 127.81 | 18 | 838 | 143 | 34955932 |
| Keratopathy | 130.32 | 127.81 | 21 | 835 | 624 | 34955451 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Conjunctival hyperaemia | 280.16 | 104.55 | 50 | 1202 | 4363 | 79738773 |
| Hypopyon | 269.07 | 104.55 | 40 | 1212 | 1102 | 79742034 |
| Corneal epithelium defect | 263.07 | 104.55 | 37 | 1215 | 682 | 79742454 |
| Corneal oedema | 235.88 | 104.55 | 40 | 1212 | 2580 | 79740556 |
| Ulcerative keratitis | 196.14 | 104.55 | 36 | 1216 | 3653 | 79739483 |
| Keratopathy | 176.99 | 104.55 | 28 | 1224 | 1166 | 79741970 |
| Endophthalmitis | 152.80 | 104.55 | 32 | 1220 | 6396 | 79736740 |
| Corneal infiltrates | 146.59 | 104.55 | 20 | 1232 | 290 | 79742846 |
| Eye pain | 138.43 | 104.55 | 42 | 1210 | 37536 | 79705600 |
| Visual acuity reduced | 121.73 | 104.55 | 36 | 1216 | 29433 | 79713703 |
| Ciliary hyperaemia | 108.09 | 104.55 | 13 | 1239 | 62 | 79743074 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01HA04 | SENSORY ORGANS OPHTHALMOLOGICALS LOCAL ANESTHETICS Local anesthetics |
| FDA EPC | N0000175539 | Local Anesthetic |
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D000779 | Anesthetics, Local |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| FDA PE | N0000175976 | Local Anesthesia |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Administration of Corneal Anesthesia | indication | ||
| Local Anesthesia for Ophthalmologic Procedure | indication | ||
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Heart disease | contraindication | 56265001 | DOID:114 |
| Eye infection | contraindication | 128351009 | |
| Uveitis | contraindication | 128473001 | DOID:13141 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Multiple Species | Ophthalmic anesthetic | Indication |
| Multiple Species | Anesthetic in cauterization of corneal ulcers, minor surgery, removal of sutures from the cornea, removal of foreign bodies cornea | Indication |
| Multiple Species | For examination and treatment of painful otitis, and prior to catheterization | Indication |
| Multiple Species | For removal of foreign bodies from eye, ear, and nose | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Ophthaine Solution | Zoetis Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.8 | Basic |
| pKa2 | 3.76 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel protein type 10 subunit alpha | Ion channel | BLOCKER | DRUGBANK | CHEMBL | |||||
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | BLOCKER | IC50 | 5.72 | CHEMBL | CHEMBL | |||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 7 | DRUG MATRIX | |||||
| Amine oxidase [flavin-containing] A | Enzyme | IC50 | 5.75 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| 4019913 | VUID |
| N0000179224 | NUI |
| D02098 | KEGG_DRUG |
| 5875-06-9 | SECONDARY_CAS_RN |
| 4017727 | VANDF |
| 4019913 | VANDF |
| C0072510 | UMLSCUI |
| CHEBI:8485 | CHEBI |
| CHEMBL1196 | ChEMBL_ID |
| DB00807 | DRUGBANK_ID |
| CHEMBL1200464 | ChEMBL_ID |
| C005717 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4935 | PUBCHEM_CID |
| 7283 | IUPHAR_LIGAND_ID |
| 540 | INN_ID |
| B4OB0JHI1X | UNII |
| 203759 | RXNORM |
| 3827 | MMSL |
| 39893 | MMSL |
| 5370 | MMSL |
| 7955 | MMSL |
| 001360 | NDDF |
| 004572 | NDDF |
| 30424002 | SNOMEDCT_US |
| 349837002 | SNOMEDCT_US |
| 373465008 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-7199 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Alcaine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0998-0016 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 15 sections |
| Alcaine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0998-0016 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 15 sections |
| Alcaine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0998-0016 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 15 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13985-611 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 17 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-195 | SOLUTION | 5 mg | OPHTHALMIC | ANDA | 10 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-263 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 18 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-263 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 18 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-530 | SOLUTION | 5 mg | OPHTHALMIC | ANDA | 18 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-730 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0259 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 17 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1923 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1931 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-705 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Fluorescein Sodium and Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 59390-205 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | UNAPPROVED DRUG OTHER | 10 sections |
| Fluorescein Sodium and Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 59390-205 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | UNAPPROVED DRUG OTHER | 10 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61314-016 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61314-016 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68071-4368 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68071-4368 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68071-4701 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| proparacaine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68071-5139 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 15 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70518-3408 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Proparacaine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70518-3408 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 16 sections |
| Mydriatic-4 | HUMAN PRESCRIPTION DRUG LABEL | 4 | 71384-632 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | unapproved drug other | 2 sections |