promegestone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids, progestogens | 2285 | 34184-77-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G03DB07 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS Pregnadien derivatives |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:59826 | progestins |
| CHEBI has role | CHEBI:70709 | progesterone receptor agonists |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Progesterone receptor | Nuclear hormone receptor | Kd | 9.40 | CHEMBL | |||||
| Androgen receptor | Transcription factor | IC50 | 5.88 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167398 | NUI |
| D08431 | KEGG_DRUG |
| C0033401 | UMLSCUI |
| CHEBI:73390 | CHEBI |
| CHEMBL196003 | ChEMBL_ID |
| DB13602 | DRUGBANK_ID |
| D011397 | MESH_DESCRIPTOR_UI |
| 36709 | PUBCHEM_CID |
| 2877 | IUPHAR_LIGAND_ID |
| 4287 | INN_ID |
| 9XE0V2SQYX | UNII |
| 8744 | RXNORM |
| 005721 | NDDF |
| 713439003 | SNOMEDCT_US |
Pharmaceutical products:
None