promegestone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 2285 34184-77-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • promegestone
  • surgestone
A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.
  • Molecular weight: 326.48
  • Formula: C22H30O2
  • CLOGP: 4.07
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS: -4.63
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03DB07 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS
Pregnadien derivatives
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:59826 progestins
CHEBI has role CHEBI:70709 progesterone receptor agonists

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Progesterone receptor Nuclear hormone receptor Kd 9.40 CHEMBL
Androgen receptor Transcription factor IC50 5.88 CHEMBL

External reference:

IDSource
N0000167398 NUI
D08431 KEGG_DRUG
C0033401 UMLSCUI
CHEBI:73390 CHEBI
CHEMBL196003 ChEMBL_ID
DB13602 DRUGBANK_ID
D011397 MESH_DESCRIPTOR_UI
36709 PUBCHEM_CID
2877 IUPHAR_LIGAND_ID
4287 INN_ID
9XE0V2SQYX UNII
8744 RXNORM
005721 NDDF
713439003 SNOMEDCT_US

Pharmaceutical products:

None