proglumide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| cholecystokinine antagonists, antiulcer, anxiolytic agents | 2281 | 6620-60-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.20 | g | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A02BX06 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD) |
| MeSH PA | D000897 | Anti-Ulcer Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| CHEBI has role | CHEBI:35482 | narcotic analgesic |
| CHEBI has role | CHEBI:48873 | acetylcholine receptor antagonist |
| CHEBI has role | CHEBI:49103 | drug metabolites |
| CHEBI has role | CHEBI:49201 | anti-ulcer drugs |
| CHEBI has role | CHEBI:55324 | gastrointestinal drugs |
| CHEBI has role | CHEBI:73296 | CCK antagonist |
| CHEBI has role | CHEBI:76206 | xenobiotic metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.19 | acidic |
| pKa2 | 13.51 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Gastrin/cholecystokinin type B receptor | GPCR | ANTAGONIST | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
| Histamine H2 receptor | GPCR | IC50 | 2.60 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000170242 | NUI |
| D01818 | KEGG_DRUG |
| C0033321 | UMLSCUI |
| CHEBI:32058 | CHEBI |
| CHEMBL316561 | ChEMBL_ID |
| DB13431 | DRUGBANK_ID |
| D011377 | MESH_DESCRIPTOR_UI |
| 4922 | PUBCHEM_CID |
| 893 | IUPHAR_LIGAND_ID |
| 2161 | INN_ID |
| EPL8W5565D | UNII |
| 8730 | RXNORM |
| 006165 | NDDF |
Pharmaceutical products:
None