Stem definition | Drug id | CAS RN |
---|---|---|
steroids, progestogens | 2279 | 57-83-0 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
5 | mg | P |
0.20 | g | R |
90 | mg | V |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.01 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 21.20 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 25 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 4, 1976 | FDA | ALZA | |
Sept. 27, 2021 | PMDA | FUJI PHARMA CO., LTD. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Ovarian hyperstimulation syndrome | 960.36 | 12.65 | 246 | 28954 | 3768 | 63456054 |
Temperature regulation disorder | 501.54 | 12.65 | 163 | 29037 | 5969 | 63453853 |
Food allergy | 413.21 | 12.65 | 166 | 29034 | 11235 | 63448587 |
Coeliac disease | 391.34 | 12.65 | 165 | 29035 | 12632 | 63447190 |
Exposure during pregnancy | 319.38 | 12.65 | 375 | 28825 | 155172 | 63304650 |
Immunodeficiency | 318.99 | 12.65 | 165 | 29035 | 20089 | 63439733 |
Bursitis | 245.46 | 12.65 | 173 | 29027 | 36868 | 63422954 |
Rash erythematous | 235.14 | 12.65 | 178 | 29022 | 42332 | 63417490 |
Premature labour | 208.82 | 12.65 | 106 | 29094 | 12398 | 63447424 |
Foetal exposure during pregnancy | 204.18 | 12.65 | 146 | 29054 | 31816 | 63428006 |
Abortion spontaneous | 199.92 | 12.65 | 169 | 29031 | 47026 | 63412796 |
Maternal exposure during pregnancy | 197.89 | 12.65 | 359 | 28841 | 219703 | 63240119 |
Fluid retention | 190.13 | 12.65 | 182 | 29018 | 59504 | 63400318 |
Premature delivery | 176.78 | 12.65 | 131 | 29069 | 30150 | 63429672 |
Hyperhidrosis | 169.94 | 12.65 | 228 | 28972 | 107608 | 63352214 |
Upper respiratory tract infection | 156.88 | 12.65 | 191 | 29009 | 81856 | 63377966 |
Product adhesion issue | 154.81 | 12.65 | 64 | 29136 | 4655 | 63455167 |
Meningioma | 118.41 | 12.65 | 50 | 29150 | 3835 | 63455987 |
Gestational diabetes | 114.04 | 12.65 | 62 | 29138 | 8334 | 63451488 |
Premature baby | 104.06 | 12.65 | 82 | 29118 | 20653 | 63439169 |
Asthma | 101.84 | 12.65 | 198 | 29002 | 127363 | 63332459 |
Erythema | 101.36 | 12.65 | 239 | 28961 | 175512 | 63284310 |
Foetal death | 101.10 | 12.65 | 63 | 29137 | 10917 | 63448905 |
Death | 97.40 | 12.65 | 26 | 29174 | 374355 | 63085467 |
Vaginal haemorrhage | 95.49 | 12.65 | 88 | 29112 | 27399 | 63432423 |
Headache | 91.43 | 12.65 | 549 | 28651 | 632692 | 62827130 |
Postmenopausal haemorrhage | 83.88 | 12.65 | 33 | 29167 | 2109 | 63457713 |
Pregnancy | 80.70 | 12.65 | 92 | 29108 | 36744 | 63423078 |
Autoimmune dermatitis | 78.48 | 12.65 | 17 | 29183 | 118 | 63459704 |
Oligohydramnios | 78.19 | 12.65 | 44 | 29156 | 6322 | 63453500 |
Premature rupture of membranes | 76.62 | 12.65 | 40 | 29160 | 4953 | 63454869 |
Hot flush | 75.69 | 12.65 | 105 | 29095 | 51054 | 63408768 |
Butterfly rash | 75.40 | 12.65 | 29 | 29171 | 1744 | 63458078 |
Maternal exposure before pregnancy | 73.49 | 12.65 | 45 | 29155 | 7558 | 63452264 |
Systemic lupus erythematosus | 70.89 | 12.65 | 7 | 29193 | 208911 | 63250911 |
Toxicity to various agents | 70.56 | 12.65 | 14 | 29186 | 247236 | 63212586 |
Pre-eclampsia | 68.33 | 12.65 | 46 | 29154 | 9087 | 63450735 |
Glossodynia | 66.28 | 12.65 | 4 | 29196 | 178872 | 63280950 |
Off label use | 66.03 | 12.65 | 532 | 28668 | 673930 | 62785892 |
Constipation | 64.89 | 12.65 | 239 | 28961 | 224704 | 63235118 |
Placenta accreta | 64.69 | 12.65 | 16 | 29184 | 210 | 63459612 |
Congenital absence of vertebra | 63.60 | 12.65 | 12 | 29188 | 36 | 63459786 |
Synovitis | 61.52 | 12.65 | 7 | 29193 | 186911 | 63272911 |
Wound | 59.45 | 12.65 | 4 | 29196 | 163259 | 63296563 |
Back pain | 58.88 | 12.65 | 259 | 28941 | 263886 | 63195936 |
Drug hypersensitivity | 58.53 | 12.65 | 290 | 28910 | 310397 | 63149425 |
Congenital vesicoureteric reflux | 55.87 | 12.65 | 10 | 29190 | 20 | 63459802 |
Ectopic pregnancy | 55.59 | 12.65 | 26 | 29174 | 2541 | 63457281 |
Atrial septal defect | 54.45 | 12.65 | 36 | 29164 | 6902 | 63452920 |
Acute kidney injury | 53.77 | 12.65 | 27 | 29173 | 263388 | 63196434 |
Pneumonia | 52.17 | 12.65 | 81 | 29119 | 456686 | 63003136 |
Normal newborn | 50.71 | 12.65 | 37 | 29163 | 8304 | 63451518 |
Arthropathy | 49.54 | 12.65 | 23 | 29177 | 234769 | 63225053 |
Vulvovaginal discomfort | 48.16 | 12.65 | 23 | 29177 | 2355 | 63457467 |
Haemorrhage in pregnancy | 46.38 | 12.65 | 21 | 29179 | 1904 | 63457918 |
Abortion threatened | 45.92 | 12.65 | 15 | 29185 | 557 | 63459265 |
Preterm premature rupture of membranes | 45.84 | 12.65 | 19 | 29181 | 1390 | 63458432 |
Ovarian enlargement | 43.92 | 12.65 | 14 | 29186 | 480 | 63459342 |
Subdural hygroma | 43.56 | 12.65 | 12 | 29188 | 245 | 63459577 |
Periorbital oedema | 43.41 | 12.65 | 29 | 29171 | 5655 | 63454167 |
Pericarditis | 43.10 | 12.65 | 5 | 29195 | 131574 | 63328248 |
Progesterone decreased | 42.05 | 12.65 | 10 | 29190 | 110 | 63459712 |
Prescribed overdose | 41.65 | 12.65 | 64 | 29136 | 34089 | 63425733 |
Small for dates baby | 40.92 | 12.65 | 24 | 29176 | 3727 | 63456095 |
Hepatic enzyme increased | 39.57 | 12.65 | 191 | 29009 | 202137 | 63257685 |
Intermenstrual bleeding | 39.02 | 12.65 | 31 | 29169 | 7895 | 63451927 |
Hormone level abnormal | 38.41 | 12.65 | 20 | 29180 | 2463 | 63457359 |
Completed suicide | 38.03 | 12.65 | 10 | 29190 | 145663 | 63314159 |
Gastroschisis | 37.66 | 12.65 | 12 | 29188 | 411 | 63459411 |
Adnexal torsion | 36.83 | 12.65 | 12 | 29188 | 442 | 63459380 |
Abdominal discomfort | 36.50 | 12.65 | 57 | 29143 | 320828 | 63138994 |
Foetal growth restriction | 36.02 | 12.65 | 29 | 29171 | 7524 | 63452298 |
Blister | 35.67 | 12.65 | 8 | 29192 | 129806 | 63330016 |
Head discomfort | 35.46 | 12.65 | 37 | 29163 | 13378 | 63446444 |
Human herpesvirus 6 infection | 35.13 | 12.65 | 20 | 29180 | 2937 | 63456885 |
Ventricular septal defect | 35.04 | 12.65 | 23 | 29177 | 4355 | 63455467 |
Periodic limb movement disorder | 34.62 | 12.65 | 10 | 29190 | 244 | 63459578 |
Single umbilical artery | 34.31 | 12.65 | 10 | 29190 | 252 | 63459570 |
Uterine haemorrhage | 34.23 | 12.65 | 22 | 29178 | 4019 | 63455803 |
Hypersensitivity | 34.17 | 12.65 | 241 | 28959 | 292444 | 63167378 |
Blood oestrogen decreased | 34.09 | 12.65 | 10 | 29190 | 258 | 63459564 |
Photosensitivity reaction | 33.77 | 12.65 | 38 | 29162 | 14956 | 63444866 |
HELLP syndrome | 33.70 | 12.65 | 14 | 29186 | 1030 | 63458792 |
Abortion missed | 32.92 | 12.65 | 16 | 29184 | 1703 | 63458119 |
Rheumatoid arthritis | 32.60 | 12.65 | 214 | 28986 | 253605 | 63206217 |
Breast hyperplasia | 32.59 | 12.65 | 10 | 29190 | 302 | 63459520 |
Endometrial stromal sarcoma | 32.06 | 12.65 | 6 | 29194 | 17 | 63459805 |
Ovarian haemorrhage | 31.80 | 12.65 | 10 | 29190 | 328 | 63459494 |
Suicidal behaviour | 31.76 | 12.65 | 18 | 29182 | 2621 | 63457201 |
Product use issue | 31.46 | 12.65 | 191 | 29009 | 220329 | 63239493 |
Caesarean section | 31.45 | 12.65 | 39 | 29161 | 16993 | 63442829 |
Neutropenia | 31.33 | 12.65 | 21 | 29179 | 174984 | 63284838 |
Ophthalmic vein thrombosis | 31.26 | 12.65 | 9 | 29191 | 217 | 63459605 |
Swelling | 31.22 | 12.65 | 49 | 29151 | 275329 | 63184493 |
Ascites | 30.97 | 12.65 | 62 | 29138 | 40666 | 63419156 |
Confusional state | 30.86 | 12.65 | 38 | 29162 | 236342 | 63223480 |
Product odour abnormal | 30.79 | 12.65 | 14 | 29186 | 1282 | 63458540 |
Sepsis | 30.76 | 12.65 | 16 | 29184 | 153107 | 63306715 |
General physical health deterioration | 30.02 | 12.65 | 29 | 29171 | 201373 | 63258449 |
Psoriasis | 29.88 | 12.65 | 98 | 29102 | 86859 | 63372963 |
Therapeutic product effect decreased | 29.76 | 12.65 | 27 | 29173 | 193160 | 63266662 |
Retroplacental haematoma | 29.39 | 12.65 | 8 | 29192 | 156 | 63459666 |
Decreased appetite | 29.10 | 12.65 | 44 | 29156 | 251008 | 63208814 |
Twin pregnancy | 28.91 | 12.65 | 13 | 29187 | 1160 | 63458662 |
Breast tenderness | 28.20 | 12.65 | 16 | 29184 | 2334 | 63457488 |
Anaemia | 28.08 | 12.65 | 58 | 29142 | 293372 | 63166450 |
Tinnitus | 28.01 | 12.65 | 55 | 29145 | 35573 | 63424249 |
Product quality issue | 27.76 | 12.65 | 55 | 29145 | 35810 | 63424012 |
Retained placenta or membranes | 27.50 | 12.65 | 9 | 29191 | 336 | 63459486 |
Ovarian cyst | 27.05 | 12.65 | 35 | 29165 | 15910 | 63443912 |
Cardiac arrest | 26.88 | 12.65 | 5 | 29195 | 92540 | 63367282 |
Cyanosis neonatal | 26.00 | 12.65 | 9 | 29191 | 400 | 63459422 |
Decidual cast | 24.50 | 12.65 | 4 | 29196 | 3 | 63459819 |
Peripheral swelling | 24.24 | 12.65 | 54 | 29146 | 265888 | 63193934 |
Patent ductus arteriosus | 23.92 | 12.65 | 18 | 29182 | 4232 | 63455590 |
Hippocampal sclerosis | 23.58 | 12.65 | 6 | 29194 | 89 | 63459733 |
Pelvic infection | 22.83 | 12.65 | 8 | 29192 | 369 | 63459453 |
Application site pruritus | 22.71 | 12.65 | 17 | 29183 | 3967 | 63455855 |
Talipes | 22.67 | 12.65 | 12 | 29188 | 1528 | 63458294 |
Anxiety | 22.43 | 12.65 | 174 | 29026 | 217367 | 63242455 |
Complication of pregnancy | 22.35 | 12.65 | 9 | 29191 | 611 | 63459211 |
Menopausal symptoms | 22.35 | 12.65 | 14 | 29186 | 2447 | 63457375 |
Folliculitis | 22.22 | 12.65 | 3 | 29197 | 70314 | 63389508 |
Lower respiratory tract infection | 22.21 | 12.65 | 17 | 29183 | 132290 | 63327532 |
Hypotonia neonatal | 22.08 | 12.65 | 11 | 29189 | 1235 | 63458587 |
Vaginal discharge | 21.90 | 12.65 | 24 | 29176 | 9174 | 63450648 |
Application site erythema | 21.87 | 12.65 | 18 | 29182 | 4817 | 63455005 |
Product use in unapproved indication | 21.77 | 12.65 | 149 | 29051 | 178931 | 63280891 |
Subchorionic haematoma | 21.67 | 12.65 | 6 | 29194 | 125 | 63459697 |
Vomiting | 21.48 | 12.65 | 160 | 29040 | 559457 | 62900365 |
Drug abuse | 20.88 | 12.65 | 4 | 29196 | 72514 | 63387308 |
Mediastinal effusion | 20.86 | 12.65 | 5 | 29195 | 57 | 63459765 |
Malignant neoplasm progression | 20.75 | 12.65 | 6 | 29194 | 82115 | 63377707 |
Stomatitis | 20.63 | 12.65 | 20 | 29180 | 138705 | 63321117 |
Nerve compression | 20.41 | 12.65 | 23 | 29177 | 9064 | 63450758 |
Congenital umbilical hernia | 20.33 | 12.65 | 7 | 29193 | 306 | 63459516 |
Carnitine deficiency | 20.19 | 12.65 | 6 | 29194 | 162 | 63459660 |
Cardiac failure | 19.94 | 12.65 | 8 | 29192 | 89134 | 63370688 |
Hypotension | 19.79 | 12.65 | 62 | 29138 | 272542 | 63187280 |
Infection | 19.70 | 12.65 | 48 | 29152 | 229125 | 63230697 |
Application site rash | 19.69 | 12.65 | 13 | 29187 | 2485 | 63457337 |
Cholestasis of pregnancy | 19.33 | 12.65 | 10 | 29190 | 1215 | 63458607 |
Wheezing | 19.18 | 12.65 | 10 | 29190 | 95585 | 63364237 |
Hydrops foetalis | 19.11 | 12.65 | 8 | 29192 | 600 | 63459222 |
Irritable bowel syndrome | 19.10 | 12.65 | 7 | 29193 | 82405 | 63377417 |
Disease progression | 19.08 | 12.65 | 17 | 29183 | 122741 | 63337081 |
Tubo-ovarian abscess | 19.06 | 12.65 | 7 | 29193 | 370 | 63459452 |
Ovarian abscess | 18.93 | 12.65 | 6 | 29194 | 202 | 63459620 |
Renal failure | 18.64 | 12.65 | 16 | 29184 | 117636 | 63342186 |
Oestradiol increased | 18.64 | 12.65 | 5 | 29195 | 92 | 63459730 |
Gastrointestinal haemorrhage | 18.63 | 12.65 | 7 | 29193 | 81169 | 63378653 |
Temporal lobe epilepsy | 18.47 | 12.65 | 7 | 29193 | 404 | 63459418 |
Haemoglobin decreased | 18.34 | 12.65 | 24 | 29176 | 145461 | 63314361 |
Eosinophilic pneumonia acute | 18.23 | 12.65 | 7 | 29193 | 419 | 63459403 |
Renal impairment | 18.09 | 12.65 | 9 | 29191 | 88346 | 63371476 |
Cardiac failure congestive | 18.06 | 12.65 | 10 | 29190 | 92423 | 63367399 |
Muscle injury | 18.00 | 12.65 | 4 | 29196 | 65341 | 63394481 |
Hypogonadism | 17.89 | 12.65 | 5 | 29195 | 108 | 63459714 |
Fallopian tube disorder | 17.74 | 12.65 | 7 | 29193 | 451 | 63459371 |
Febrile neutropenia | 17.70 | 12.65 | 17 | 29183 | 118432 | 63341390 |
Low birth weight baby | 17.67 | 12.65 | 19 | 29181 | 7110 | 63452712 |
Dyspnoea | 17.66 | 12.65 | 207 | 28993 | 661106 | 62798716 |
Postpartum haemorrhage | 17.31 | 12.65 | 11 | 29189 | 1970 | 63457852 |
Therapeutic response unexpected | 17.29 | 12.65 | 31 | 29169 | 18728 | 63441094 |
Turner's syndrome | 17.12 | 12.65 | 5 | 29195 | 127 | 63459695 |
Abdominal pain lower | 17.07 | 12.65 | 37 | 29163 | 25641 | 63434181 |
Selective eating disorder | 16.86 | 12.65 | 11 | 29189 | 2061 | 63457761 |
Diarrhoea | 16.84 | 12.65 | 230 | 28970 | 715136 | 62744686 |
Breast enlargement | 16.62 | 12.65 | 10 | 29190 | 1626 | 63458196 |
Feeling abnormal | 16.59 | 12.65 | 121 | 29079 | 148271 | 63311551 |
Neonatal asphyxia | 16.45 | 12.65 | 6 | 29194 | 311 | 63459511 |
Ultrasound liver abnormal | 16.35 | 12.65 | 4 | 29196 | 50 | 63459772 |
Mobility decreased | 16.30 | 12.65 | 19 | 29181 | 121140 | 63338682 |
Endometrial hyperplasia | 16.28 | 12.65 | 8 | 29192 | 872 | 63458950 |
Enlarged clitoris | 16.23 | 12.65 | 5 | 29195 | 153 | 63459669 |
Biochemical pregnancy | 16.16 | 12.65 | 3 | 29197 | 8 | 63459814 |
COVID-19 | 16.13 | 12.65 | 98 | 29102 | 113005 | 63346817 |
Application site irritation | 16.00 | 12.65 | 10 | 29190 | 1740 | 63458082 |
Overdose | 15.96 | 12.65 | 99 | 29101 | 114979 | 63344843 |
Palatal polyp | 15.90 | 12.65 | 3 | 29197 | 9 | 63459813 |
Platelet count decreased | 15.85 | 12.65 | 18 | 29182 | 116104 | 63343718 |
Drug exposure before pregnancy | 15.83 | 12.65 | 8 | 29192 | 926 | 63458896 |
Opisthotonus | 15.77 | 12.65 | 6 | 29194 | 350 | 63459472 |
Primary hypogonadism | 15.62 | 12.65 | 5 | 29195 | 174 | 63459648 |
Premature separation of placenta | 15.44 | 12.65 | 10 | 29190 | 1851 | 63457971 |
Injection site pain | 15.17 | 12.65 | 107 | 29093 | 129693 | 63330129 |
Chronic obstructive pulmonary disease | 15.08 | 12.65 | 5 | 29195 | 62681 | 63397141 |
Incorrect dose administered | 15.02 | 12.65 | 61 | 29139 | 59907 | 63399915 |
Impaired healing | 15.00 | 12.65 | 15 | 29185 | 102527 | 63357295 |
Fall | 14.63 | 12.65 | 113 | 29087 | 392221 | 63067601 |
Product taste abnormal | 14.48 | 12.65 | 10 | 29190 | 2057 | 63457765 |
Retinal vein occlusion | 14.16 | 12.65 | 10 | 29190 | 2133 | 63457689 |
Arterial intramural haematoma | 14.09 | 12.65 | 3 | 29197 | 19 | 63459803 |
Heterotopic pregnancy | 14.09 | 12.65 | 3 | 29197 | 19 | 63459803 |
Cardio-respiratory arrest | 14.05 | 12.65 | 5 | 29195 | 59954 | 63399868 |
Binge eating | 14.01 | 12.65 | 6 | 29194 | 476 | 63459346 |
Pulmonary oedema | 13.88 | 12.65 | 4 | 29196 | 54869 | 63404953 |
Anti-Muellerian hormone level decreased | 13.75 | 12.65 | 4 | 29196 | 100 | 63459722 |
Application site urticaria | 13.73 | 12.65 | 5 | 29195 | 258 | 63459564 |
Chorioretinopathy | 13.67 | 12.65 | 7 | 29193 | 832 | 63458990 |
Respiratory disorder neonatal | 13.67 | 12.65 | 8 | 29192 | 1237 | 63458585 |
Endometrial cancer stage I | 13.66 | 12.65 | 5 | 29195 | 262 | 63459560 |
Product physical issue | 13.64 | 12.65 | 14 | 29186 | 4966 | 63454856 |
Dehydration | 13.60 | 12.65 | 38 | 29162 | 173316 | 63286506 |
Foetal hypokinesia | 13.57 | 12.65 | 6 | 29194 | 514 | 63459308 |
Amniotic cavity infection | 13.56 | 12.65 | 8 | 29192 | 1255 | 63458567 |
Blood oestrogen increased | 13.46 | 12.65 | 4 | 29196 | 108 | 63459714 |
Keratoconus | 13.37 | 12.65 | 3 | 29197 | 25 | 63459797 |
Lung disorder | 13.27 | 12.65 | 6 | 29194 | 62255 | 63397567 |
Pancytopenia | 13.26 | 12.65 | 15 | 29185 | 96918 | 63362904 |
Feeling hot | 13.23 | 12.65 | 52 | 29148 | 50302 | 63409520 |
Oesophageal atresia | 13.20 | 12.65 | 6 | 29194 | 549 | 63459273 |
Abortion early | 13.16 | 12.65 | 3 | 29197 | 27 | 63459795 |
Drug intolerance | 12.91 | 12.65 | 86 | 29114 | 308575 | 63151247 |
Pyogenic granuloma | 12.87 | 12.65 | 5 | 29195 | 309 | 63459513 |
Liver tenderness | 12.81 | 12.65 | 4 | 29196 | 128 | 63459694 |
Bradycardia | 12.81 | 12.65 | 9 | 29191 | 73218 | 63386604 |
Abortion | 12.80 | 12.65 | 10 | 29190 | 2486 | 63457336 |
Live birth | 12.77 | 12.65 | 33 | 29167 | 25597 | 63434225 |
Malaise | 12.76 | 12.65 | 126 | 29074 | 415828 | 63043994 |
Musculoskeletal stiffness | 12.68 | 12.65 | 43 | 29157 | 184575 | 63275247 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Foetal exposure during pregnancy | 701.50 | 85.14 | 173 | 933 | 37928 | 34917897 |
Premature baby | 362.17 | 85.14 | 90 | 1016 | 19543 | 34936282 |
Atrial septal defect | 151.22 | 85.14 | 37 | 1069 | 7355 | 34948470 |
Low birth weight baby | 133.79 | 85.14 | 34 | 1072 | 7871 | 34947954 |
Hypospadias | 107.59 | 85.14 | 24 | 1082 | 3177 | 34952648 |
Congenital hydronephrosis | 101.95 | 85.14 | 18 | 1088 | 715 | 34955110 |
Human herpesvirus 6 infection | 88.86 | 85.14 | 19 | 1087 | 2062 | 34953763 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Ovarian hyperstimulation syndrome | 1015.01 | 14.18 | 228 | 21815 | 3343 | 79719002 |
Temperature regulation disorder | 545.18 | 14.18 | 153 | 21890 | 5700 | 79716645 |
Food allergy | 464.34 | 14.18 | 156 | 21887 | 10668 | 79711677 |
Coeliac disease | 453.15 | 14.18 | 155 | 21888 | 11196 | 79711149 |
Immunodeficiency | 361.61 | 14.18 | 157 | 21886 | 21611 | 79700734 |
Exposure during pregnancy | 322.40 | 14.18 | 248 | 21795 | 100884 | 79621461 |
Bursitis | 303.91 | 14.18 | 163 | 21880 | 35681 | 79686664 |
Maternal exposure during pregnancy | 257.65 | 14.18 | 248 | 21795 | 136290 | 79586055 |
Rash erythematous | 246.22 | 14.18 | 169 | 21874 | 57600 | 79664745 |
Fluid retention | 224.09 | 14.18 | 172 | 21871 | 69637 | 79652708 |
Premature delivery | 188.49 | 14.18 | 103 | 21940 | 23364 | 79698981 |
Upper respiratory tract infection | 178.28 | 14.18 | 169 | 21874 | 90999 | 79631346 |
Hyperhidrosis | 155.17 | 14.18 | 200 | 21843 | 151292 | 79571053 |
Abortion spontaneous | 153.99 | 14.18 | 98 | 21945 | 29409 | 79692936 |
Premature labour | 144.13 | 14.18 | 62 | 21981 | 8328 | 79714017 |
Asthma | 139.34 | 14.18 | 179 | 21864 | 134916 | 79587429 |
Headache | 130.20 | 14.18 | 436 | 21607 | 653336 | 79069009 |
Gestational diabetes | 123.08 | 14.18 | 51 | 21992 | 6242 | 79716103 |
Erythema | 110.60 | 14.18 | 211 | 21832 | 223079 | 79499266 |
Meningioma | 108.97 | 14.18 | 42 | 22001 | 4256 | 79718089 |
Foetal death | 101.73 | 14.18 | 48 | 21995 | 7996 | 79714349 |
Rheumatoid arthritis | 100.77 | 14.18 | 195 | 21848 | 208275 | 79514070 |
Hepatic enzyme increased | 98.44 | 14.18 | 179 | 21864 | 182431 | 79539914 |
Death | 97.95 | 14.18 | 19 | 22024 | 566495 | 79155850 |
Butterfly rash | 91.11 | 14.18 | 29 | 22014 | 1667 | 79720678 |
Back pain | 90.10 | 14.18 | 234 | 21809 | 303946 | 79418399 |
Drug hypersensitivity | 88.58 | 14.18 | 230 | 21813 | 298686 | 79423659 |
Premature rupture of membranes | 86.47 | 14.18 | 35 | 22008 | 4034 | 79718311 |
Pre-eclampsia | 85.94 | 14.18 | 41 | 22002 | 7000 | 79715345 |
Acute kidney injury | 82.55 | 14.18 | 21 | 22022 | 519383 | 79202962 |
Vaginal haemorrhage | 81.65 | 14.18 | 59 | 21984 | 21758 | 79700587 |
Maternal exposure before pregnancy | 80.68 | 14.18 | 34 | 22009 | 4339 | 79718006 |
Autoimmune dermatitis | 77.82 | 14.18 | 16 | 22027 | 149 | 79722196 |
Toxicity to various agents | 77.49 | 14.18 | 12 | 22031 | 421528 | 79300817 |
Constipation | 75.97 | 14.18 | 210 | 21833 | 282840 | 79439505 |
Hypersensitivity | 73.81 | 14.18 | 198 | 21845 | 262041 | 79460304 |
Placenta accreta | 73.74 | 14.18 | 16 | 22027 | 197 | 79722148 |
Normal newborn | 70.86 | 14.18 | 36 | 22007 | 7036 | 79715309 |
Product adhesion issue | 67.04 | 14.18 | 26 | 22017 | 2678 | 79719667 |
Haemorrhage in pregnancy | 59.10 | 14.18 | 20 | 22023 | 1394 | 79720951 |
Keratoconus | 57.86 | 14.18 | 12 | 22031 | 117 | 79722228 |
Ovarian enlargement | 55.05 | 14.18 | 14 | 22029 | 354 | 79721991 |
Prescribed overdose | 51.81 | 14.18 | 58 | 21985 | 37825 | 79684520 |
Abortion threatened | 48.31 | 14.18 | 13 | 22030 | 412 | 79721933 |
Off label use | 47.51 | 14.18 | 419 | 21624 | 906796 | 78815549 |
Pneumonia | 46.69 | 14.18 | 69 | 21974 | 660177 | 79062168 |
Periorbital oedema | 46.55 | 14.18 | 29 | 22014 | 8373 | 79713972 |
Hot flush | 46.27 | 14.18 | 66 | 21977 | 54811 | 79667534 |
Uterine haemorrhage | 45.13 | 14.18 | 20 | 22023 | 2883 | 79719462 |
Head discomfort | 44.87 | 14.18 | 35 | 22008 | 14467 | 79707878 |
HELLP syndrome | 44.20 | 14.18 | 14 | 22029 | 792 | 79721553 |
Ectopic pregnancy | 44.07 | 14.18 | 17 | 22026 | 1726 | 79720619 |
Contraindicated product administered | 41.32 | 14.18 | 116 | 21927 | 157422 | 79564923 |
Product use issue | 40.64 | 14.18 | 139 | 21904 | 209683 | 79512662 |
Fatigue | 40.48 | 14.18 | 413 | 21630 | 929314 | 78793031 |
Vulvovaginal discomfort | 39.71 | 14.18 | 16 | 22027 | 1822 | 79720523 |
Breast hyperplasia | 39.23 | 14.18 | 9 | 22034 | 145 | 79722200 |
Completed suicide | 38.85 | 14.18 | 10 | 22033 | 245757 | 79476588 |
Postmenopausal haemorrhage | 38.75 | 14.18 | 15 | 22028 | 1537 | 79720808 |
Neutropenia | 37.96 | 14.18 | 16 | 22027 | 287694 | 79434651 |
Pain | 37.76 | 14.18 | 327 | 21716 | 703475 | 79018870 |
Ovarian haemorrhage | 37.49 | 14.18 | 10 | 22033 | 306 | 79722039 |
Photosensitivity reaction | 37.17 | 14.18 | 37 | 22006 | 21090 | 79701255 |
Cardiac arrest | 36.33 | 14.18 | 3 | 22040 | 172093 | 79550252 |
Adnexal torsion | 35.59 | 14.18 | 10 | 22033 | 373 | 79721972 |
Ophthalmic vein thrombosis | 35.26 | 14.18 | 9 | 22034 | 231 | 79722114 |
Pregnancy | 34.82 | 14.18 | 40 | 22003 | 26811 | 79695534 |
Twin pregnancy | 34.82 | 14.18 | 12 | 22031 | 884 | 79721461 |
Psoriasis | 34.05 | 14.18 | 76 | 21967 | 89511 | 79632834 |
Caesarean section | 33.99 | 14.18 | 28 | 22015 | 12507 | 79709838 |
Suicidal behaviour | 33.91 | 14.18 | 17 | 22026 | 3230 | 79719115 |
Drug abuse | 33.89 | 14.18 | 3 | 22040 | 162688 | 79559657 |
Intermenstrual bleeding | 31.82 | 14.18 | 20 | 22023 | 5864 | 79716481 |
Sepsis | 30.99 | 14.18 | 18 | 22025 | 269410 | 79452935 |
Anaemia | 30.92 | 14.18 | 47 | 21996 | 444968 | 79277377 |
Synovitis | 30.81 | 14.18 | 3 | 22040 | 150731 | 79571614 |
Preterm premature rupture of membranes | 30.71 | 14.18 | 12 | 22031 | 1261 | 79721084 |
Retroplacental haematoma | 29.94 | 14.18 | 7 | 22036 | 123 | 79722222 |
Hypotension | 29.17 | 14.18 | 48 | 21995 | 440269 | 79282076 |
Confusional state | 29.12 | 14.18 | 27 | 22016 | 317970 | 79404375 |
Endometrial stromal sarcoma | 29.04 | 14.18 | 5 | 22038 | 15 | 79722330 |
Menopausal symptoms | 28.84 | 14.18 | 13 | 22030 | 1950 | 79720395 |
Hormone level abnormal | 28.59 | 14.18 | 13 | 22030 | 1989 | 79720356 |
Oligohydramnios | 27.45 | 14.18 | 15 | 22028 | 3397 | 79718948 |
Tinnitus | 27.13 | 14.18 | 46 | 21997 | 44287 | 79678058 |
Renal failure | 26.78 | 14.18 | 11 | 22032 | 200957 | 79521388 |
Pelvic infection | 26.69 | 14.18 | 8 | 22035 | 376 | 79721969 |
Ovarian abscess | 26.68 | 14.18 | 6 | 22037 | 88 | 79722257 |
Product odour abnormal | 26.64 | 14.18 | 11 | 22032 | 1333 | 79721012 |
Decidual cast | 26.54 | 14.18 | 4 | 22039 | 3 | 79722342 |
Decreased appetite | 25.93 | 14.18 | 34 | 22009 | 342384 | 79379961 |
Oestradiol increased | 25.91 | 14.18 | 6 | 22037 | 101 | 79722244 |
Febrile neutropenia | 25.76 | 14.18 | 16 | 22027 | 230983 | 79491362 |
Ovarian cyst | 25.73 | 14.18 | 24 | 22019 | 12631 | 79709714 |
Progesterone decreased | 25.34 | 14.18 | 5 | 22038 | 37 | 79722308 |
Foetal growth restriction | 24.83 | 14.18 | 12 | 22031 | 2107 | 79720238 |
Foetal exposure during pregnancy | 24.78 | 14.18 | 17 | 22026 | 5773 | 79716572 |
Retained placenta or membranes | 24.71 | 14.18 | 7 | 22036 | 269 | 79722076 |
Ascites | 24.24 | 14.18 | 60 | 21983 | 75502 | 79646843 |
Abortion missed | 23.75 | 14.18 | 10 | 22033 | 1273 | 79721072 |
Blood oestrogen decreased | 23.62 | 14.18 | 6 | 22037 | 151 | 79722194 |
Gastrointestinal haemorrhage | 23.35 | 14.18 | 6 | 22037 | 147713 | 79574632 |
Mediastinal effusion | 23.24 | 14.18 | 5 | 22038 | 59 | 79722286 |
Tubo-ovarian abscess | 23.21 | 14.18 | 7 | 22036 | 336 | 79722009 |
Cardiac failure | 23.16 | 14.18 | 7 | 22036 | 154835 | 79567510 |
Cholestasis of pregnancy | 22.69 | 14.18 | 9 | 22034 | 984 | 79721361 |
Complication of pregnancy | 22.48 | 14.18 | 7 | 22036 | 374 | 79721971 |
Bradycardia | 22.42 | 14.18 | 5 | 22038 | 135552 | 79586793 |
Swelling face | 22.26 | 14.18 | 56 | 21987 | 71156 | 79651189 |
General physical health deterioration | 22.22 | 14.18 | 26 | 22017 | 275212 | 79447133 |
Abdominal pain lower | 22.18 | 14.18 | 35 | 22008 | 31747 | 79690598 |
Renal impairment | 22.08 | 14.18 | 8 | 22035 | 157775 | 79564570 |
Hypotonia neonatal | 21.94 | 14.18 | 5 | 22038 | 78 | 79722267 |
Fallopian tube disorder | 21.89 | 14.18 | 7 | 22036 | 408 | 79721937 |
Nerve compression | 21.69 | 14.18 | 19 | 22024 | 9220 | 79713125 |
Postpartum haemorrhage | 21.66 | 14.18 | 10 | 22033 | 1585 | 79720760 |
Porphyria non-acute | 21.44 | 14.18 | 8 | 22035 | 741 | 79721604 |
Systemic lupus erythematosus | 21.01 | 14.18 | 4 | 22039 | 121145 | 79601200 |
Amniotic cavity infection | 20.67 | 14.18 | 8 | 22035 | 819 | 79721526 |
Malignant neoplasm progression | 20.60 | 14.18 | 6 | 22037 | 135984 | 79586361 |
Carnitine deficiency | 20.16 | 14.18 | 6 | 22037 | 275 | 79722070 |
Injection site pain | 20.06 | 14.18 | 80 | 21963 | 129758 | 79592587 |
Hirsutism | 19.82 | 14.18 | 9 | 22034 | 1373 | 79720972 |
Nephrocalcinosis | 19.10 | 14.18 | 9 | 22034 | 1493 | 79720852 |
Breast enlargement | 18.62 | 14.18 | 9 | 22034 | 1580 | 79720765 |
Platelet count decreased | 18.44 | 14.18 | 16 | 22027 | 194648 | 79527697 |
Breast tenderness | 18.32 | 14.18 | 10 | 22033 | 2258 | 79720087 |
Placental insufficiency | 18.31 | 14.18 | 8 | 22035 | 1115 | 79721230 |
Cardio-respiratory arrest | 17.95 | 14.18 | 4 | 22039 | 108506 | 79613839 |
Primary hypogonadism | 17.91 | 14.18 | 5 | 22038 | 182 | 79722163 |
Haemoglobin decreased | 17.91 | 14.18 | 21 | 22022 | 222098 | 79500247 |
Feeling hot | 17.66 | 14.18 | 46 | 21997 | 59688 | 79662657 |
COVID-19 | 17.46 | 14.18 | 88 | 21955 | 157586 | 79564759 |
Congenital hydronephrosis | 17.43 | 14.18 | 3 | 22040 | 9 | 79722336 |
Cardiac failure congestive | 17.10 | 14.18 | 9 | 22034 | 142393 | 79579952 |
Respiratory failure | 16.97 | 14.18 | 15 | 22028 | 180896 | 79541449 |
Blister | 16.81 | 14.18 | 6 | 22037 | 119470 | 79602875 |
Glossodynia | 16.72 | 14.18 | 4 | 22039 | 103333 | 79619012 |
Binge eating | 16.66 | 14.18 | 6 | 22037 | 503 | 79721842 |
Arthropathy | 16.24 | 14.18 | 15 | 22028 | 177096 | 79545249 |
Ovarian cyst ruptured | 16.13 | 14.18 | 7 | 22036 | 959 | 79721386 |
Failed induction of labour | 15.83 | 14.18 | 5 | 22038 | 280 | 79722065 |
Anti-Muellerian hormone level decreased | 15.77 | 14.18 | 4 | 22039 | 100 | 79722245 |
Heterotopic pregnancy | 15.61 | 14.18 | 3 | 22040 | 19 | 79722326 |
Product taste abnormal | 15.60 | 14.18 | 9 | 22034 | 2262 | 79720083 |
Dehydration | 15.55 | 14.18 | 28 | 22015 | 248159 | 79474186 |
Endometrial hyperplasia | 15.36 | 14.18 | 6 | 22037 | 630 | 79721715 |
Subchorionic haematoma | 15.34 | 14.18 | 4 | 22039 | 112 | 79722233 |
Eosinophilic pneumonia acute | 15.27 | 14.18 | 7 | 22036 | 1091 | 79721254 |
Pulmonary oedema | 15.12 | 14.18 | 3 | 22040 | 88251 | 79634094 |
Heavy menstrual bleeding | 15.10 | 14.18 | 19 | 22024 | 13992 | 79708353 |
Pericarditis | 15.07 | 14.18 | 5 | 22038 | 104231 | 79618114 |
Depressed mood | 15.02 | 14.18 | 38 | 22005 | 48442 | 79673903 |
Live birth | 15 | 14.18 | 22 | 22021 | 18722 | 79703623 |
Genital haemorrhage | 14.96 | 14.18 | 13 | 22030 | 6242 | 79716103 |
Vaginal discharge | 14.88 | 14.18 | 14 | 22029 | 7449 | 79714896 |
Embedded device | 14.81 | 14.18 | 10 | 22033 | 3309 | 79719036 |
Retinal vein occlusion | 14.80 | 14.18 | 10 | 22033 | 3313 | 79719032 |
Erythema nodosum | 14.67 | 14.18 | 12 | 22031 | 5305 | 79717040 |
Drug interaction | 14.65 | 14.18 | 62 | 21981 | 415121 | 79307224 |
Hallucination | 14.51 | 14.18 | 3 | 22040 | 85742 | 79636603 |
Chronic obstructive pulmonary disease | 14.43 | 14.18 | 3 | 22040 | 85416 | 79636929 |
Product quality issue | 14.26 | 14.18 | 30 | 22013 | 33910 | 79688435 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Human herpesvirus 6 infection | 46.81 | 37.71 | 15 | 363 | 45 | 89369 |
Congestive cardiomyopathy | 40.41 | 37.71 | 14 | 364 | 57 | 89357 |
Source | Code | Description |
---|---|---|
ATC | G03DA04 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS Pregnen (4) derivatives |
ATC | G03FA04 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, fixed combinations |
FDA CS | M0017672 | Progesterone |
MeSH PA | D009465 | Neuromuscular Agents |
MeSH PA | D009466 | Neuromuscular Blocking Agents |
MeSH PA | D003473 | Neuromuscular Nondepolarizing Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D006728 | Hormones |
MeSH PA | D011372 | Progestins |
FDA EPC | N0000175601 | Progesterone |
CHEBI has role | CHEBI:49323 | contraceptive drugs |
CHEBI has role | CHEBI:59826 | progestins |
CHEBI has role | CHEBI:70709 | progesterone receptor agonists |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Contraception | indication | 13197004 | |
Dysfunctional uterine bleeding | indication | 19155002 | |
Atrophic vaginitis | indication | 52441000 | |
Secondary physiologic amenorrhea | indication | 86030004 | |
Secondary malignant neoplasm of kidney | indication | 94360002 | |
Postmenopausal osteoporosis | indication | 102447009 | |
Endometriosis | indication | 129103003 | |
Menopausal flushing | indication | 198436008 | |
Endometrial carcinoma | indication | 254878006 | DOID:2871 |
Infertility Secondary to Progesterone Deficiency | indication | ||
Amenorrhea Secondary to Ovarian Dysfunction | indication | ||
Prevention of Premature Labor | indication | ||
Endometrial Hyperplasia Prevention | indication | ||
Corpus Luteum Insufficiency Syndrome | indication | ||
Polycystic ovaries | off-label use | 69878008 | |
Menorrhagia | off-label use | 386692008 | |
Precocious puberty | off-label use | 400179000 | |
Endogenous Estrogen Production Test | off-label use | ||
Female Hormonal Imbalance | off-label use | ||
Hyperlipoproteinemia | contraindication | 3744001 | DOID:1168 |
Hypocalcemia | contraindication | 5291005 | |
Alcoholism | contraindication | 7200002 | |
Weight gain finding | contraindication | 8943002 | |
Impaired glucose tolerance | contraindication | 9414007 | |
Hypercholesterolemia | contraindication | 13644009 | |
Jaundice | contraindication | 18165001 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Fibroadenosis of breast | contraindication | 23260002 | DOID:10352 |
Diplopia | contraindication | 24982008 | |
Retinal hemorrhage | contraindication | 28998008 | |
Ectopic pregnancy | contraindication | 34801009 | DOID:0060329 |
Depressive disorder | contraindication | 35489007 | |
Chloasma | contraindication | 36209000 | |
Migraine | contraindication | 37796009 | DOID:6364 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Mild pre-eclampsia | contraindication | 41114007 | |
Body fluid retention | contraindication | 43498006 | |
Thrombosis of retinal vein | contraindication | 46085004 | |
Humoral hypercalcemia of malignancy | contraindication | 47709007 | |
Chronic heart failure | contraindication | 48447003 | |
Dementia | contraindication | 52448006 | |
Hepatic porphyria | contraindication | 55056006 | DOID:3133 |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
Anorexia nervosa | contraindication | 56882008 | DOID:8689 |
Hepatic failure | contraindication | 59927004 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Thrombophlebitis | contraindication | 64156001 | DOID:3875 |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Intermenstrual bleeding - irregular | contraindication | 64996003 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Breast lump | contraindication | 89164003 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Malignant neoplasm of liver | contraindication | 93870000 | DOID:3571 |
Uterine leiomyoma | contraindication | 95315005 | DOID:13223 |
Neoplasm of liver | contraindication | 126851005 | DOID:3571 |
Deep venous thrombosis | contraindication | 128053003 | |
Seizure disorder | contraindication | 128613002 | |
Incomplete miscarriage | contraindication | 156072005 | |
Bed-ridden | contraindication | 160685001 | |
Mammography abnormal | contraindication | 168750009 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Cerebrovascular accident | contraindication | 230690007 | |
Pulmonary thromboembolism | contraindication | 233935004 | |
Thrombophilia | contraindication | 234467004 | DOID:2452 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Chorea | contraindication | 271700006 | |
Pregnancy, function | contraindication | 289908002 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Osteopenia | contraindication | 312894000 | |
Functional visual loss | contraindication | 313165001 | |
Malignant tumor of ovary | contraindication | 363443007 | DOID:2394 |
Thromboembolic disorder | contraindication | 371039008 | |
Cardiovascular event risk | contraindication | 395112001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Estrogen receptor positive tumor | contraindication | 416053008 | |
Porphyria | contraindication | 418470004 | |
Optic disc edema | contraindication | 423341008 | DOID:146 |
Family history of malignant neoplasm of breast | contraindication | 429740004 | |
Hypertensive urgency | contraindication | 443482000 | |
Carcinoma of female breast | contraindication | 447782002 | |
Smokes tobacco daily | contraindication | 449868002 | |
Predisposition to Thrombosis | contraindication |
Species | Use | Relation |
---|---|---|
Cattle | Estrus synchronization | Indication |
Cattle | Induction of estrous cycles | Indication |
Cattle | Synchronization of the return to estrus | Indication |
Cattle | Advancement of first postpartum estrus | Indication |
Cattle | Advancement of first pubertal estrus | Indication |
Cattle | To increase rate of weight gain | Indication |
Cattle | To improve feed efficiency | Indication |
Sheep | Estrus induction | Indication |
Product | Applicant | Ingredients |
---|---|---|
Synovex C, Synovex S | Zoetis Inc. | 2 |
Component E-C with Tylan, Component E-S with Tylan | Elanco US Inc. | 3 |
EAZI-BREED CIDR Cattle Insert | Zoetis Inc. | 1 |
EAZI-BREED CIDR Sheep Insert | Zoetis Inc. | 1 |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
1.78GM | MILPROSA | FERRING PHARMS INC | N201110 | April 29, 2020 | DISCN | SYSTEM | VAGINAL | 10548904 | Feb. 3, 2029 | METHOD OF SUPPORTING EMBRYO IMPLANTATION AND EARLY PREGNANCY BY SUPPLEMENTATION OF CORPUS LUTEAL FUNCTION AS PART OF AN ASSISTED REPRODUCTIVE TECHNOLOGY (ART) TREATMENT PROGRAM FOR INFERTILE WOMEN |
1.78GM | MILPROSA | FERRING PHARMS INC | N201110 | April 29, 2020 | DISCN | SYSTEM | VAGINAL | 8580293 | Jan. 21, 2030 | METHOD OF SUPPORTING EMBRYO IMPLANTATION AND EARLY PREGNANCY BY SUPPLEMENTATION OF CORPUS LUTEAL FUNCTION AS PART OF AN ASSISTED REPRODUCTIVE TECHNOLOGY (ART) TREATMENT PROGRAM FOR INFERTILE WOMEN |
0.5MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Dec. 28, 2021 | DISCN | CAPSULE | ORAL | 10206932 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
0.5MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Dec. 28, 2021 | DISCN | CAPSULE | ORAL | 10675288 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
0.5MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Dec. 28, 2021 | DISCN | CAPSULE | ORAL | 11033626 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
0.5MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Dec. 28, 2021 | DISCN | CAPSULE | ORAL | 8846648 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
0.5MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Dec. 28, 2021 | DISCN | CAPSULE | ORAL | 8846649 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
0.5MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Dec. 28, 2021 | DISCN | CAPSULE | ORAL | 8933059 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
0.5MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Dec. 28, 2021 | DISCN | CAPSULE | ORAL | 9114145 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
0.5MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Dec. 28, 2021 | DISCN | CAPSULE | ORAL | 9114146 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
0.5MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Dec. 28, 2021 | DISCN | CAPSULE | ORAL | 9301920 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 10206932 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 10675288 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 10806740 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 11033626 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 11103513 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 8846648 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 8846649 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 9006222 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 9114145 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 9114146 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
1MG;100MG | BIJUVA | MAYNE PHARMA | N210132 | Oct. 28, 2018 | RX | CAPSULE | ORAL | 9301920 | Nov. 21, 2032 | TREATMENT OF MENOPAUSE SYMPTOMS, INCLUDING VASOMOTOR SYMPTOMS |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
1.78GM | MILPROSA | FERRING PHARMS INC | N201110 | April 29, 2020 | DISCN | SYSTEM | VAGINAL | April 29, 2023 | NEW PRODUCT |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Progesterone receptor | Nuclear hormone receptor | AGONIST | ED50 | 9.88 | WOMBAT-PK | CHEMBL | |||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.59 | CHEMBL | |||||
Multidrug resistance protein 1 | Transporter | IC50 | 4.32 | CHEMBL | |||||
Glucocorticoid receptor | Nuclear hormone receptor | Ki | 7.52 | CHEMBL | |||||
Mineralocorticoid receptor | Nuclear hormone receptor | EC50 | 11 | WOMBAT-PK | |||||
Estrogen receptor | Nuclear hormone receptor | WOMBAT-PK | |||||||
Androgen receptor | Nuclear hormone receptor | Ki | 8.07 | CHEMBL | |||||
Corticosteroid-binding globulin | Secreted | Ki | 7.38 | CHEMBL | |||||
Sex hormone-binding globulin | Secreted | Kd | 6.94 | CHEMBL | |||||
Sterol O-acyltransferase 1 | Enzyme | IC50 | 4.77 | CHEMBL | |||||
Fatty acid-binding protein, intestinal | Cytosolic other | Ki | 4.70 | CHEMBL | |||||
Cation channel sperm-associated protein 1 | Ion channel | ACTIVATOR | EC50 | 8.11 | IUPHAR | ||||
Cation channel sperm-associated protein 2 | Ion channel | ACTIVATOR | EC50 | 8.11 | IUPHAR | ||||
Cation channel sperm-associated protein 3 | Ion channel | ACTIVATOR | EC50 | 8.11 | IUPHAR | ||||
Cation channel sperm-associated protein 4 | Ion channel | ACTIVATOR | EC50 | 8.11 | IUPHAR | ||||
Short transient receptor potential channel 5 | Ion channel | BLOCKER | IC50 | 5.30 | IUPHAR | ||||
Sodium/nucleoside cotransporter 1 | Transporter | Ki | 5.17 | DRUG MATRIX | |||||
P2X purinoceptor 3 | Ion channel | IC50 | 5.80 | CHEMBL | |||||
Androgen receptor | Transcription factor | IC50 | 5.81 | CHEMBL | |||||
Fatty acid-binding protein, liver | Unclassified | Ki | 7.57 | CHEMBL | |||||
Progesterone receptor | Transcription factor | Ki | 8.44 | DRUG MATRIX | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Kd | 6.62 | CHEMBL | |||||
Androgen receptor | Transcription factor | IC50 | 7.43 | CHEMBL | |||||
Progesterone receptor | Transcription factor | Ki | 7.98 | CHEMBL | |||||
C-8 sterol isomerase | Enzyme | Ki | 5.35 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane other | Ki | 6.18 | CHEMBL | |||||
Steroid 5-alpha-reductase | Enzyme | IC50 | 5.80 | CHEMBL | |||||
Estrogen receptor | Transcription factor | Kd | 8.41 | CHEMBL |
ID | Source |
---|---|
4017453 | VUID |
N0000145841 | NUI |
D00066 | KEGG_DRUG |
4017453 | VANDF |
C0033308 | UMLSCUI |
CHEBI:17026 | CHEBI |
STR | PDB_CHEM_ID |
CHEMBL103 | ChEMBL_ID |
DB00396 | DRUGBANK_ID |
D011374 | MESH_DESCRIPTOR_UI |
C003549 | MESH_SUPPLEMENTAL_RECORD_UI |
5994 | PUBCHEM_CID |
2377 | IUPHAR_LIGAND_ID |
417 | INN_ID |
4G7DS2Q64Y | UNII |
8727 | RXNORM |
2110 | MMSL |
53089 | MMSL |
5365 | MMSL |
d00550 | MMSL |
001290 | NDDF |
16683002 | SNOMEDCT_US |
50318003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Crinone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6150 | GEL | 45 mg | VAGINAL | NDA | 24 sections |
Crinone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6150 | GEL | 45 mg | VAGINAL | NDA | 24 sections |
Crinone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6151 | GEL | 90 mg | VAGINAL | NDA | 24 sections |
Crinone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6151 | GEL | 90 mg | VAGINAL | NDA | 24 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9725 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 13 sections |
PROGESTERONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3128 | INJECTION, SOLUTION | 50 mg | INTRAMUSCULAR | NDA | 13 sections |
PROGESTERONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-3128 | INJECTION, SOLUTION | 50 mg | INTRAMUSCULAR | NDA | 13 sections |
PROGESTERONE | Human Prescription Drug Label | 1 | 10888-7135 | CAPSULE | 100 mg | ORAL | ANDA | 21 sections |
PROGESTERONE | Human Prescription Drug Label | 1 | 10888-7136 | CAPSULE | 200 mg | ORAL | ANDA | 21 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-157 | CAPSULE | 100 mg | ORAL | ANDA | 25 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-158 | CAPSULE | 200 mg | ORAL | ANDA | 25 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-766 | CAPSULE | 100 mg | ORAL | ANDA | 23 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-767 | CAPSULE | 200 mg | ORAL | ANDA | 23 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-349 | CAPSULE | 100 mg | ORAL | ANDA | 21 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-349 | CAPSULE | 100 mg | ORAL | ANDA | 21 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-350 | CAPSULE | 200 mg | ORAL | ANDA | 21 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-350 | CAPSULE | 200 mg | ORAL | ANDA | 21 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2527 | CAPSULE | 100 mg | ORAL | ANDA | 23 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3240 | CAPSULE | 100 mg | ORAL | NDA | 24 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4656 | CAPSULE | 100 mg | ORAL | ANDA | 23 sections |
Progesterone | Human Prescription Drug Label | 1 | 50090-5928 | CAPSULE | 100 mg | ORAL | ANDA | 22 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-6475 | CAPSULE | 100 mg | ORAL | ANDA | 24 sections |
Bijuva | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50261-211 | CAPSULE | 100 mg | ORAL | NDA | 33 sections |
Bijuva | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50261-211 | CAPSULE | 100 mg | ORAL | NDA | 33 sections |
Bijuva | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50261-251 | CAPSULE | 100 mg | ORAL | NDA | 33 sections |
Progesterone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-1760 | CAPSULE | 200 mg | ORAL | ANDA | 23 sections |
Prometrium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4230 | CAPSULE | 200 mg | ORAL | NDA | 15 sections |
Prometrium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4250 | CAPSULE | 100 mg | ORAL | NDA | 15 sections |
Prochieve | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55056-0406 | GEL | 45 mg | VAGINAL | NDA | 24 sections |
Crinone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55056-0806 | GEL | 90 mg | VAGINAL | NDA | 24 sections |