dithranol indications/contra

Stem definitionDrug idCAS RN
226 1143-38-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anthralin
  • chrysodermol
  • dithranol
  • cigthranol
An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.
  • Molecular weight: 226.23
  • Formula: C14H10O3
  • CLOGP: 4.06
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 57.53
  • ALOGS: -3.09
  • ROTB: 0

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC D05AC01 DERMATOLOGICALS
ANTIPSORIATICS
ANTIPSORIATICS FOR TOPICAL USE
Antracen derivatives
ATC D05AC51 DERMATOLOGICALS
ANTIPSORIATICS
ANTIPSORIATICS FOR TOPICAL USE
Antracen derivatives
CHEBI has role CHEBI:50748 antipsoriatic
MeSH PA D003879 Dermatologic Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Psoriasis off-label use 9014002 DOID:8893
Alopecia areata off-label use 68225006 DOID:986

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.42 acidic
pKa2 11.19 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Arachidonate 12-lipoxygenase, 12R-type Enzyme WOMBAT-PK
5-lipoxygenase Enzyme IC50 4.43 CHEMBL

External reference:

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IDSource
4018598 VUID
N0000146914 NUI
C0003166 UMLSCUI
D00233 KEGG_DRUG
CHEMBL46469 ChEMBL_ID
2202 PUBCHEM_CID
4018598 VANDF
387293003 SNOMEDCT_US
24 MMSL
873 RXNORM
53800008 SNOMEDCT_US
4206 MMSL
N0000006034 NDFRT
N0000146914 NDFRT
001984 NDDF
CHEBI:37510 CHEBI
U8CJK0JH5M UNII
83 INN_ID
DB11157 DRUGBANK_ID
D000875 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
DRITHO-CREME HUMAN PRESCRIPTION DRUG LABEL 1 11086-037 CREAM 1 g TOPICAL unapproved drug other 6 sections
ZITHRANOL-RR HUMAN PRESCRIPTION DRUG LABEL 1 42783-101 CREAM 0.01 g TOPICAL unapproved drug other 2 sections
Zithranol HUMAN PRESCRIPTION DRUG LABEL 1 42783-111 SHAMPOO 1 g TOPICAL unapproved drug other 2 sections