dithranol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
226 1143-38-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anthralin
  • chrysodermol
  • dithranol
  • cigthranol
An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.
  • Molecular weight: 226.23
  • Formula: C14H10O3
  • CLOGP: 4.03
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 57.53
  • ALOGS: -3.09
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D05AC01 DERMATOLOGICALS
ANTIPSORIATICS
ANTIPSORIATICS FOR TOPICAL USE
Antracen derivatives
ATC D05AC51 DERMATOLOGICALS
ANTIPSORIATICS
ANTIPSORIATICS FOR TOPICAL USE
Antracen derivatives
MeSH PA D003879 Dermatologic Agents
CHEBI has role CHEBI:50748 antipsoriatic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Psoriasis off-label use 9014002 DOID:8893
Alopecia areata off-label use 68225006 DOID:986




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.42 acidic
pKa2 11.19 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Arachidonate 12-lipoxygenase, 12R-type Enzyme WOMBAT-PK
NAD-dependent protein deacylase sirtuin-5, mitochondrial Enzyme IC50 7 CHEMBL
Serine protease hepsin Enzyme IC50 6.64 CHEMBL
5-lipoxygenase Enzyme IC50 4.43 CHEMBL
Trypsin Enzyme IC50 5.90 CHEMBL

External reference:

IDSource
4018598 VUID
N0000146914 NUI
D00233 KEGG_DRUG
873 RXNORM
C0003166 UMLSCUI
CHEBI:37510 CHEBI
CHEMBL46469 ChEMBL_ID
DB11157 DRUGBANK_ID
2202 PUBCHEM_CID
24 MMSL
4206 MMSL
387293003 SNOMEDCT_US
53800008 SNOMEDCT_US
D000875 MESH_DESCRIPTOR_UI
83 INN_ID
4018598 VANDF
U8CJK0JH5M UNII
001984 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DRITHO-CREME HP HUMAN PRESCRIPTION DRUG LABEL 1 11086-037 CREAM 1 g TOPICAL unapproved drug other 7 sections
ZITHRANOL-RR HUMAN PRESCRIPTION DRUG LABEL 1 42783-101 cream 0.01 g TOPICAL unapproved drug other 12 sections
Zithranol HUMAN PRESCRIPTION DRUG LABEL 1 42783-111 SHAMPOO 1 g TOPICAL unapproved drug other 12 sections