prednisolone sulfobenzoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2250 630-67-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisolone sulfobenzoate
  • prednisolone metasulfobenzoate
  • prednisolone metasulfobenzoate sodium
  • prednisolone sodium metasulfobenzoate
  • prednisolone metazoate
  • prednisolone sodium metazoate
  • Molecular weight: 544.62
  • Formula: C28H32O9S
  • CLOGP: 0.82
  • LIPINSKI: 1
  • HAC: 9
  • HDO: 3
  • TPSA: 155.27
  • ALOGS: -4.11
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.22 mg/mL Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 82 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,MAPKAPK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK 20
kinase-selectivity-class AXL,GRK2,MAP2K6,TEK 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Urinary retention 70.63 50.69 23 947 37721 90589756
Head injury 62.39 50.69 20 950 31168 90596309
Hepatocellular injury 59.69 50.69 19 951 28939 90598538

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Retinal artery occlusion 37.30 33.86 9 1011 2206 42618109
Respiratory alkalosis 36.80 33.86 9 1011 2335 42617980
Fixed eruption 36.39 33.86 9 1011 2445 42617870

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatocellular injury 63.69 31.61 27 2112 50615 110536545
Hepatic cytolysis 55.10 31.61 25 2114 55028 110532132
Agranulocytosis 52.36 31.61 25 2114 61735 110525425
Cholestasis 51.32 31.61 25 2114 64493 110522667
Febrile bone marrow aplasia 50.02 31.61 17 2122 17448 110569712
Fixed eruption 47.97 31.61 12 2127 4220 110582940
Urinary retention 46.58 31.61 24 2115 69659 110517501
Head injury 44.51 31.61 20 2119 42997 110544163
Retinal artery occlusion 42.97 31.61 11 2128 4238 110582922
Rash maculo-papular 39.58 31.61 22 2117 74200 110512960
Bone marrow failure 36.00 31.61 19 2120 57829 110529331
Pancreatitis acute 35.27 31.61 19 2120 60255 110526905

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018931 Antineoplastic Agents, Hormonal
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35472 anti-inflammatory drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35816 leprostatic drug
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:37962 adrenergic agent
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:49103 drug metabolite
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50671 antithyroid drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76595 nephroprotective agent
CHEBI has role CHEBI:77715 nasal decongestant
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.78 acidic
pKa2 13.36 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D08413 KEGG_DRUG
3694-41-5 SECONDARY_CAS_RN
4017988 VANDF
TUA PDB_CHEM_ID
CHEMBL2111103 ChEMBL_ID
CHEMBL2107364 ChEMBL_ID
181625 PUBCHEM_CID
268872 RXNORM
5347 MMSL
59710 MMSL
d00084 MMSL
002155 NDDF
005522 NDDF
116601002 SNOMEDCT_US
52388000 SNOMEDCT_US
897039000 SNOMEDCT_US
C0889299 UMLSCUI
C0032950 UMLSCUI
CHEBI:135823 CHEBI
DB00860 DRUGBANK_ID
5755 PUBCHEM_CID
535 INN_ID
D011239 MESH_DESCRIPTOR_UI
SR3YX73FW2 UNII
CHEBI:8378 CHEBI
SR3YX73FW2 INXIGHT DRUGS

Pharmaceutical products:

None