prednisolone acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2247 52-21-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisolone acetate
  • hydroprednisone acetate
  • meticortelone acetate
  • meticotelone acetate
  • Molecular weight: 402.49
  • Formula: C23H30O6
  • CLOGP: 1.96
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -3.98
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.22 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
May 22, 1955 FDA SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Treatment failure 265.00 14.36 206 7369 198837 63282610
Corneal epithelium defect 193.80 14.36 34 7541 318 63481129
Intraocular pressure increased 188.34 14.36 56 7519 6022 63475425
Eye irritation 176.15 14.36 74 7501 21897 63459550
Eye pain 175.38 14.36 84 7491 33770 63447677
Corneal oedema 166.06 14.36 38 7537 1455 63479992
Visual acuity reduced 160.01 14.36 69 7506 21757 63459690
Endophthalmitis 146.53 14.36 41 7534 3551 63477896
Corneal disorder 143.30 14.36 35 7540 1779 63479668
Vision blurred 141.48 14.36 104 7471 91820 63389627
Corneal opacity 127.55 14.36 27 7548 716 63480731
Toxic anterior segment syndrome 109.09 14.36 28 7547 1743 63479704
Punctate keratitis 109.08 14.36 23 7552 598 63480849
Ocular hyperaemia 102.37 14.36 53 7522 25091 63456356
Anterior chamber cell 89.00 14.36 19 7556 525 63480922
Uveitis 86.46 14.36 38 7537 12515 63468932
Product delivery mechanism issue 84.18 14.36 17 7558 355 63481092
Cataract 79.77 14.36 61 7514 56992 63424455
Eye inflammation 77.32 14.36 28 7547 5571 63475876
Hypopyon 67.47 14.36 16 7559 716 63480731
Corneal transplant 63.99 14.36 13 7562 280 63481167
Vitritis 62.64 14.36 16 7559 976 63480471
Foreign body sensation in eyes 62.36 14.36 19 7556 2215 63479232
Corneal infiltrates 60.26 14.36 11 7564 131 63481316
Glaucoma 57.86 14.36 33 7542 18872 63462575
Product container issue 57.61 14.36 17 7558 1776 63479671
Keratitis bacterial 57.44 14.36 9 7566 38 63481409
Photophobia 54.55 14.36 31 7544 17604 63463843
Keratitis 54.40 14.36 19 7556 3403 63478044
Corneal graft rejection 53.70 14.36 8 7567 22 63481425
Corneal deposits 52.12 14.36 11 7564 287 63481160
Visual impairment 52 14.36 57 7518 84389 63397058
Iridocyclitis 47.89 14.36 16 7559 2506 63478941
Vitreous haemorrhage 47.00 14.36 15 7560 2035 63479412
Iritis 44.29 14.36 16 7559 3159 63478288
Corneal scar 43.10 14.36 8 7567 105 63481342
Conjunctival ulcer 42.92 14.36 7 7568 40 63481407
Cystoid macular oedema 42.28 14.36 13 7562 1562 63479885
Tractional retinal detachment 42.08 14.36 7 7568 46 63481401
Cataract subcapsular 39.51 14.36 10 7565 588 63480859
Ulcerative keratitis 39.09 14.36 14 7561 2696 63478751
Conjunctival hyperaemia 37.01 14.36 13 7562 2366 63479081
Rhegmatogenous retinal detachment 36.60 14.36 7 7568 109 63481338
Hyphaema 35.34 14.36 8 7567 291 63481156
Vitreous floaters 34.53 14.36 16 7559 5950 63475497
Retinal detachment 34.52 14.36 16 7559 5953 63475494
Infectious crystalline keratopathy 33.50 14.36 5 7570 14 63481433
Complications of transplant surgery 33.38 14.36 7 7568 177 63481270
Corneal perforation 30.53 14.36 8 7567 540 63480907
Product residue present 30.51 14.36 13 7562 3966 63477481
Eye infection toxoplasmal 30.09 14.36 7 7568 288 63481159
Fibrous histiocytoma 29.98 14.36 8 7567 579 63480868
Blindness 29.85 14.36 23 7552 21676 63459771
Ocular discomfort 29.74 14.36 13 7562 4220 63477227
Product quality issue 28.91 14.36 28 7547 35837 63445610
Foreign body in eye 28.87 14.36 6 7569 145 63481302
Hypotony of eye 28.68 14.36 6 7569 150 63481297
Liquid product physical issue 28.55 14.36 9 7566 1173 63480274
Immobile 28.48 14.36 14 7561 5929 63475518
Eye discharge 28.22 14.36 14 7561 6049 63475398
Eye disorder 26.83 14.36 22 7553 22663 63458784
Scleral thinning 25.51 14.36 4 7571 17 63481430
Corneal thinning 24.59 14.36 5 7570 108 63481339
Infective keratitis 22.64 14.36 4 7571 39 63481408
Instillation site pain 22.32 14.36 7 7568 897 63480550
Macular oedema 21.20 14.36 10 7565 3867 63477580
Astigmatism 21.18 14.36 7 7568 1060 63480387
Corneal abrasion 20.82 14.36 7 7568 1117 63480330
Metamorphopsia 20.59 14.36 7 7568 1156 63480291
Lenticular opacities 20.52 14.36 5 7570 251 63481196
Lacrimation increased 20.29 14.36 18 7557 20613 63460834
Off label use 19.95 14.36 143 7432 674319 62807128
Instillation site foreign body sensation 19.70 14.36 3 7572 10 63481437
Angle closure glaucoma 19.54 14.36 8 7567 2211 63479236
Blindness unilateral 19.37 14.36 11 7564 6230 63475217
Vitreous opacities 19.31 14.36 5 7570 322 63481125
Persistent corneal epithelial defect 19.28 14.36 3 7572 12 63481435
Corneal neovascularisation 18.65 14.36 4 7571 113 63481334
Product complaint 18.55 14.36 14 7561 12795 63468652
Bedridden 18.08 14.36 13 7562 11038 63470409
Corneal endotheliitis 17.99 14.36 3 7572 20 63481427
Lower limb fracture 17.83 14.36 18 7557 24203 63457244
Corneal thickening 17.74 14.36 3 7572 22 63481425
Accidental exposure to product 17.72 14.36 19 7556 27386 63454061
Cytomegalovirus chorioretinitis 17.63 14.36 7 7568 1786 63479661
Keratitis fungal 17.23 14.36 4 7571 163 63481284
Corynebacterium infection 16.65 14.36 5 7570 554 63480893
Foot fracture 16.21 14.36 17 7558 23897 63457550
Eye swelling 16.21 14.36 17 7558 23901 63457546
Keratopathy 16.18 14.36 5 7570 611 63480836
Conjunctival haemorrhage 15.86 14.36 8 7567 3579 63477868
Product substitution issue 15.82 14.36 14 7561 15982 63465465
Eye operation 15.74 14.36 7 7568 2365 63479082
Product physical consistency issue 15.55 14.36 5 7570 694 63480753
Conjunctival oedema 15.53 14.36 5 7570 697 63480750
Retinitis viral 15.33 14.36 3 7572 53 63481394
Vitreous haze 15.33 14.36 3 7572 53 63481394
Open angle glaucoma 15.26 14.36 4 7571 270 63481177
Corneal erosion 14.86 14.36 4 7571 299 63481148
Anterior chamber inflammation 14.56 14.36 4 7571 323 63481124
Abnormal sensation in eye 14.36 14.36 6 7569 1743 63479704

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Endophthalmitis 264.47 17.09 69 5485 3439 34947938
Treatment failure 256.82 17.09 132 5422 46565 34904812
Intraocular pressure increased 222.08 17.09 66 5488 5317 34946060
Eye pain 205.18 17.09 78 5476 13384 34937993
Visual acuity reduced 144.77 17.09 64 5490 16085 34935292
Corneal oedema 123.46 17.09 31 5523 1320 34950057
Cataract 109.96 17.09 62 5492 26124 34925253
Corneal epithelium defect 102.04 17.09 21 5533 358 34951019
Ulcerative keratitis 97.21 17.09 27 5527 1702 34949675
Corneal opacity 82.18 17.09 19 5535 567 34950810
Glaucoma 73.73 17.09 31 5523 6881 34944496
Choroiditis 73.04 17.09 20 5534 1195 34950182
Toxic anterior segment syndrome 69.15 17.09 19 5535 1150 34950227
Ocular hyperaemia 67.46 17.09 34 5520 11418 34939959
Uveitis 64.70 17.09 29 5525 7506 34943871
Corneal scar 55.74 17.09 11 5543 150 34951227
Vision blurred 55.60 17.09 51 5503 45912 34905465
Eye irritation 55.20 17.09 26 5528 7535 34943842
Foreign body sensation in eyes 55.20 17.09 14 5540 620 34950757
Cystoid macular oedema 53.53 17.09 14 5540 701 34950676
Anterior chamber cell 46.47 17.09 11 5543 364 34951013
Flat anterior chamber of eye 45.49 17.09 8 5546 55 34951322
Corneal disorder 45.31 17.09 13 5541 921 34950456
Keratitis 43.74 17.09 14 5540 1437 34949940
Astigmatism 43.25 17.09 13 5541 1084 34950293
Corneal perforation 41.68 17.09 9 5545 195 34951182
Vitritis 41.43 17.09 12 5542 879 34950498
NPM1 gene mutation 39.95 17.09 8 5546 118 34951259
Corneal thinning 38.72 17.09 8 5546 139 34951238
Corneal infiltrates 37.99 17.09 8 5546 153 34951224
Photophobia 36.16 17.09 19 5535 6945 34944432
Bronchiolitis obliterans syndrome 36.03 17.09 8 5546 198 34951179
Chimerism 34.71 17.09 8 5546 235 34951142
Iris adhesions 34.36 17.09 8 5546 246 34951131
Eye infection 34.30 17.09 15 5539 3658 34947719
Eye inflammation 30.70 17.09 12 5542 2206 34949171
CSF pressure increased 30.70 17.09 5 5549 20 34951357
Corneal deposits 30.01 17.09 7 5547 217 34951160
Iris atrophy 29.93 17.09 6 5548 89 34951288
Corneal graft rejection 28.74 17.09 5 5549 32 34951345
Keratitis fungal 27.20 17.09 6 5548 144 34951233
Idiopathic intracranial hypertension 26.31 17.09 8 5546 693 34950684
Hypopyon 26.05 17.09 7 5547 389 34950988
Retinal detachment 25.99 17.09 14 5540 5377 34946000
Visual impairment 25.63 17.09 30 5524 35772 34915605
Necrotising scleritis 24.77 17.09 5 5549 77 34951300
Liquid product physical issue 24.41 17.09 7 5547 495 34950882
Ocular discomfort 24.19 17.09 10 5544 2124 34949253
Eye disorder 23.26 17.09 16 5538 9512 34941865
Conjunctival hyperaemia 23.05 17.09 10 5544 2392 34948985
Pupillary disorder 22.59 17.09 6 5548 319 34951058
Ophthalmic herpes simplex 22.50 17.09 6 5548 324 34951053
Vitreous opacities 21.86 17.09 6 5548 361 34951016
Persistent corneal epithelial defect 21.79 17.09 4 5550 36 34951341
Product delivery mechanism issue 21.19 17.09 5 5549 163 34951214
Iris hypopigmentation 20.98 17.09 4 5550 45 34951332
Ocular hypertension 20.82 17.09 7 5547 837 34950540
Blindness 20.81 17.09 18 5536 14968 34936409
Blood immunoglobulin G decreased 20.49 17.09 8 5546 1465 34949912
Open globe injury 20.30 17.09 3 5551 5 34951372
Vitreous floaters 19.23 17.09 10 5544 3575 34947802
Immunosuppression 18.81 17.09 12 5542 6292 34945085
Dry eye 18.61 17.09 14 5540 9561 34941816
Epstein-Barr virus associated lymphoproliferative disorder 18.27 17.09 8 5546 1956 34949421
Eye discharge 18.11 17.09 8 5546 1998 34949379
Transplant rejection 17.69 17.09 14 5540 10297 34941080
Acute myeloid leukaemia recurrent 17.51 17.09 8 5546 2162 34949215
Steroid diabetes 17.42 17.09 8 5546 2187 34949190
Articular disc disorder 17.41 17.09 3 5551 18 34951359
Blepharitis 17.16 17.09 7 5547 1438 34949939
Punctate keratitis 17.11 17.09 5 5549 378 34950999

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Endophthalmitis 388.45 13.91 103 10862 6325 79727098
Intraocular pressure increased 365.12 13.91 106 10859 9099 79724324
Corneal epithelium defect 280.30 13.91 53 10912 666 79732757
Visual acuity reduced 267.68 13.91 113 10852 29356 79704067
Eye pain 263.19 13.91 120 10845 37458 79695965
Corneal oedema 262.88 13.91 63 10902 2557 79730866
Corneal opacity 180.70 13.91 39 10926 981 79732442
Corneal disorder 163.89 13.91 42 10923 2249 79731174
Toxic anterior segment syndrome 151.38 13.91 41 10924 2723 79730700
Uveitis 134.53 13.91 59 10906 16771 79716652
Anterior chamber cell 127.88 13.91 29 10936 920 79732503
Vision blurred 127.41 13.91 110 10855 105788 79627635
Ulcerative keratitis 122.29 13.91 37 10928 3652 79729771
Cataract 119.11 13.91 85 10880 62035 79671388
Punctate keratitis 116.11 13.91 27 10938 959 79732464
Glaucoma 104.31 13.91 52 10913 19709 79713714
Vitritis 100.06 13.91 27 10938 1767 79731656
Eye irritation 99.17 13.91 51 10914 20630 79712793
Ocular hyperaemia 97.52 13.91 56 10909 28150 79705273
Hypopyon 86.91 13.91 22 10943 1120 79732303
Corneal scar 84.97 13.91 17 10948 291 79733132
Foreign body sensation in eyes 77.39 13.91 23 10942 2134 79731289
Astigmatism 76.32 13.91 20 10945 1169 79732254
Cystoid macular oedema 74.92 13.91 22 10943 1958 79731465
Corneal infiltrates 73.00 13.91 15 10950 295 79733128
Corneal deposits 71.34 13.91 16 10949 482 79732941
Keratitis 69.10 13.91 25 10940 4297 79729126
Choroiditis 68.72 13.91 19 10946 1362 79732061
Eye inflammation 66.30 13.91 27 10938 6386 79727037
Corneal transplant 65.60 13.91 14 10951 333 79733090
Keratitis bacterial 63.21 13.91 12 10953 154 79733269
Photophobia 61.09 13.91 37 10928 20491 79712932
Hypotony of eye 57.93 13.91 12 10953 246 79733177
Corneal perforation 54.63 13.91 14 10951 749 79732674
Conjunctival hyperaemia 54.05 13.91 21 10944 4392 79729031
Vitreous haemorrhage 53.89 13.91 20 10945 3693 79729730
Corneal graft rejection 53.25 13.91 9 10956 56 79733367
Iritis 49.55 13.91 19 10946 3836 79729587
Corneal thinning 49.35 13.91 10 10955 183 79733240
Iridocyclitis 46.70 13.91 18 10947 3686 79729737
NPM1 gene mutation 46.35 13.91 9 10956 131 79733292
Visual impairment 44.54 13.91 59 10906 92072 79641351
Keratitis fungal 44.19 13.91 10 10955 314 79733109
Blindness 43.54 13.91 34 10931 28349 79705074
Rhegmatogenous retinal detachment 43.33 13.91 9 10956 187 79733236
Cataract subcapsular 42.24 13.91 12 10953 949 79732474
Vitreous floaters 40.98 13.91 20 10945 7236 79726187
Persistent corneal epithelial defect 39.99 13.91 7 10958 55 79733368
Chimerism 39.63 13.91 9 10956 287 79733136
Retinal detachment 39.18 13.91 21 10944 9226 79724197
Hyphaema 38.44 13.91 11 10954 893 79732530
Bronchiolitis obliterans syndrome 38.42 13.91 9 10956 330 79733093
Ocular discomfort 38.29 13.91 17 10948 4966 79728457
Vitreous opacities 36.90 13.91 10 10955 665 79732758
Complications of transplant surgery 35.76 13.91 10 10955 747 79732676
Iris adhesions 34.16 13.91 9 10956 537 79732886
Macular oedema 33.67 13.91 16 10949 5458 79727965
Infective keratitis 33.45 13.91 6 10959 55 79733368
Iris atrophy 33.28 13.91 7 10958 155 79733268
Flat anterior chamber of eye 33.28 13.91 7 10958 155 79733268
Fibrous histiocytoma 31.70 13.91 9 10956 710 79732713
Eye infection 31.69 13.91 20 10945 11900 79721523
Corneal abrasion 30.90 13.91 10 10955 1229 79732194
Tractional retinal detachment 30.73 13.91 6 10959 90 79733333
Blindness unilateral 30.37 13.91 17 10948 8129 79725294
Necrotising scleritis 30.36 13.91 7 10958 239 79733184
Eye discharge 29.26 13.91 15 10950 6019 79727404
Scleral thinning 28.16 13.91 5 10960 43 79733380
Immobile 27.22 13.91 15 10950 6958 79726465
Lacrimation increased 26.27 13.91 23 10942 22454 79710969
Corynebacterium infection 26.20 13.91 9 10956 1329 79732094
Retinal vasculitis 26.10 13.91 9 10956 1344 79732079
Off label use 26.07 13.91 213 10752 907002 78826421
Scleral disorder 25.97 13.91 6 10959 207 79733216
Idiopathic intracranial hypertension 24.78 13.91 11 10954 3211 79730212
Cytomegalovirus chorioretinitis 24.76 13.91 13 10952 5477 79727946
Infectious crystalline keratopathy 24.58 13.91 4 10961 19 79733404
Pupillary disorder 24.45 13.91 7 10958 569 79732854
Keratoplasty 23.68 13.91 3 10962 0 79733423
Eye disorder 23.52 13.91 22 10943 23390 79710033
Transplant rejection 22.94 13.91 20 10945 19417 79714006
Instillation site pain 22.88 13.91 7 10958 716 79732707
Angle closure glaucoma 22.38 13.91 10 10955 2966 79730457
Blepharitis 21.91 13.91 10 10955 3114 79730309
Anterior chamber fibrin 21.68 13.91 5 10960 171 79733252
Open angle glaucoma 21.55 13.91 6 10959 441 79732982
Bipolar II disorder 21.50 13.91 6 10959 445 79732978
Ocular hypertension 21.37 13.91 8 10957 1512 79731911
Blood immunoglobulin G decreased 21.08 13.91 10 10955 3399 79730024
Osteoporosis 20.70 13.91 31 10934 54081 79679342
Optic nerve cupping 20.55 13.91 4 10961 59 79733364
Eye infection toxoplasmal 20.30 13.91 6 10959 546 79732877
Iris hypopigmentation 20.19 13.91 4 10961 65 79733358
Anterior chamber inflammation 20.07 13.91 6 10959 568 79732855
Conjunctivitis 19.96 13.91 21 10944 25694 79707729
CSF pressure increased 19.76 13.91 5 10960 254 79733169
Choroidal detachment 19.46 13.91 6 10959 630 79732793
Keratopathy 19.44 13.91 7 10958 1187 79732236
Foreign body in eye 19.39 13.91 5 10960 274 79733149
Tuberculosis of eye 19.22 13.91 4 10961 84 79733339
Necrotising retinitis 19.15 13.91 7 10958 1238 79732185
Immunosuppression 18.91 13.91 15 10950 12788 79720635
Metamorphopsia 18.89 13.91 7 10958 1286 79732137
Corneal endotheliitis 18.87 13.91 4 10961 92 79733331
Graft complication 18.49 13.91 6 10959 743 79732680
Vitreous haze 18.36 13.91 4 10961 105 79733318
Acute graft versus host disease in skin 18.26 13.91 12 10953 7646 79725777
Acute myeloid leukaemia recurrent 18.13 13.91 9 10956 3374 79730049
Glare 18.01 13.91 4 10961 115 79733308
Corneal erosion 17.86 13.91 5 10960 375 79733048
Articular disc disorder 17.84 13.91 3 10962 18 79733405
Steroid diabetes 17.83 13.91 9 10956 3497 79729926
Epstein-Barr virus associated lymphoproliferative disorder 17.76 13.91 9 10956 3523 79729900
Conjunctival retraction 17.70 13.91 3 10962 19 79733404
Corneal thickening 17.44 13.91 3 10962 21 79733402
Radiation pneumonitis 16.85 13.91 9 10956 3924 79729499
Corneal neovascularisation 16.74 13.91 4 10961 160 79733263
Anterior chamber flare 16.71 13.91 4 10961 161 79733262
Product delivery mechanism issue 16.46 13.91 4 10961 172 79733251
Lower limb fracture 16.34 13.91 18 10947 23197 79710226
Posterior capsule opacification 16.03 13.91 4 10961 192 79733231
Conjunctival haemorrhage 15.99 13.91 10 10955 5855 79727568
Mycotic endophthalmitis 15.91 13.91 4 10961 198 79733225
Ciliary body disorder 15.77 13.91 3 10962 39 79733384
Cytomegalovirus infection 15.70 13.91 24 10941 42620 79690803
Bedridden 15.42 13.91 13 10952 12066 79721357
Product container issue 15.30 13.91 6 10959 1285 79732138
Aortic aneurysm rupture 15.28 13.91 6 10959 1289 79732134
Vitreous disorder 14.89 13.91 4 10961 257 79733166
Toxicity to various agents 14.71 13.91 22 10943 421518 79311905
Macular fibrosis 14.69 13.91 5 10960 718 79732705
Diffuse large B-cell lymphoma refractory 14.69 13.91 6 10959 1429 79731994
Scleromalacia 14.65 13.91 3 10962 58 79733365
Ophthalmic herpes simplex 14.64 13.91 5 10960 725 79732698
Eye pruritus 14.56 13.91 16 10949 20554 79712869
Eye swelling 14.42 13.91 18 10947 26450 79706973
Intraocular pressure fluctuation 14.19 13.91 3 10962 68 79733355
Ciliary hyperaemia 14.03 13.91 3 10962 72 79733351
Overdose 13.97 13.91 4 10961 184202 79549221

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D006728 Hormones
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D005938 Glucocorticoids
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:49103 drug metabolites
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Blepharoconjunctivitis indication 68659002 DOID:2456
Iridocyclitis indication 77971008
Bacterial conjunctivitis indication 128350005 DOID:9700
Uveitis indication 128473001 DOID:13141
Infective blepharitis indication 312219000
Superficial Ocular Infection indication
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Tuberculosis of eye contraindication 49107007
Diabetes mellitus contraindication 73211009 DOID:9351
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Eye infection contraindication 128351009
Bacterial infection of eye contraindication 128984004
Viral eye infection contraindication 312132001
Vaccinia keratitis contraindication 397552005
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Conjunctivitis Indication
Dogs Otitis externa Indication
Cats Inflammation Indication
Cats Acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis Indication
Cats Supportive therapy in nonspecific dermatosis such as summer eczema and atopy Indication
Cats Supportive therapy pre- and post-operatively Indication
Cats Infectious allergic keratitis Indication
Cats Traumatic keratitis Indication
Cats Conjunctivitis Indication
Cats Otitis externa Indication
Cats Chronic otitis externa Indication
Dogs Inflammation Indication
Dogs Acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis Indication
Dogs Supportive therapy in nonspecific dermatosis such as summer eczema and atopy Indication
Dogs Supportive therapy pre- and post-operatively Indication
Dogs Infectious allergic keratitis Indication
Dogs Traumatic keratitis Indication
Dogs Chronic otitis externa Indication
Horses Inflammation Indication
Horses Acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis Indication
Horses Supportive therapy in nonspecific dermatosis such as summer eczema and atopy Indication
Horses Supportive therapy pre- and post-operatively Indication
Horses Infectious allergic keratitis Indication
Horses Traumatic keratitis Indication
Horses Conjunctivitis Indication
Horses Otitis externa Indication
Horses Chronic otitis externa Indication

🐶 Veterinary products

ProductApplicantIngredients
Meticortelone Acetate Intervet Inc. 1
Neo-Delta-Cortef with Tetracaine Ointment Zoetis Inc. 3
Neo-Delta Cortef Sterile Solution Zoetis Inc. 2
Surolan Elanco US Inc. 3

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.65 acidic
pKa2 13.36 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 15MG BASE/5ML FLO-PRED TARO N022067 Jan. 17, 2008 DISCN SUSPENSION ORAL 7799331 Oct. 11, 2028 TREATMENT OF ALLERGIC REACTIONS
EQ 15MG BASE/5ML FLO-PRED TARO N022067 Jan. 17, 2008 DISCN SUSPENSION ORAL 7799331 Oct. 11, 2028 TREATMENT OF ASTHMA
EQ 5MG BASE/5ML FLO-PRED TARO N022067 Jan. 17, 2008 DISCN SUSPENSION ORAL 7799331 Oct. 11, 2028 TREATMENT OF ALLERGIC REACTIONS
EQ 5MG BASE/5ML FLO-PRED TARO N022067 Jan. 17, 2008 DISCN SUSPENSION ORAL 7799331 Oct. 11, 2028 TREATMENT OF ASTHMA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4017989 VUID
N0000179219 NUI
D00980 KEGG_DRUG
4017988 VANDF
4017989 VANDF
C0071839 UMLSCUI
CHEBI:8380 CHEBI
CHEBI:8378 CHEBI
TUA PDB_CHEM_ID
CHEMBL1152 ChEMBL_ID
DB15566 DRUGBANK_ID
C009935 MESH_SUPPLEMENTAL_RECORD_UI
5834 PUBCHEM_CID
8B2807733D UNII
DB00860 DRUGBANK_ID
34372 RXNORM
25176 MMSL
4601 MMSL
5347 MMSL
5348 MMSL
59710 MMSL
d00084 MMSL
002155 NDDF
002156 NDDF
116601002 SNOMEDCT_US
52388000 SNOMEDCT_US
96334000 SNOMEDCT_US
C0032950 UMLSCUI
535 INN_ID
5755 PUBCHEM_CID
D011239 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PRED-G HUMAN PRESCRIPTION DRUG LABEL 2 0023-0066 OINTMENT 6 mg OPHTHALMIC NDA 17 sections
PRED-G HUMAN PRESCRIPTION DRUG LABEL 2 0023-0106 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA 18 sections
BLEPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 2 0023-0313 OINTMENT 2 mg OPHTHALMIC ANDA 19 sections
BLEPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 2 11980-022 SUSPENSION/ DROPS 2 mg OPHTHALMIC NDA 20 sections
PRED MILD HUMAN PRESCRIPTION DRUG LABEL 1 11980-174 SUSPENSION/ DROPS 1.20 mg OPHTHALMIC NDA 18 sections
PRED MILD HUMAN PRESCRIPTION DRUG LABEL 1 11980-174 SUSPENSION/ DROPS 1.20 mg OPHTHALMIC NDA 18 sections
PRED FORTE HUMAN PRESCRIPTION DRUG LABEL 1 11980-180 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA 18 sections
PRED FORTE HUMAN PRESCRIPTION DRUG LABEL 1 11980-180 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA 18 sections
Prednisolone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0559 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA authorized generic 18 sections
Prednisolone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0559 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA authorized generic 18 sections
Prednisolone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0561 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA authorized generic 17 sections
PREDNISOLONE ACETATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-1912 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA AUTHORIZED GENERIC 18 sections
PREDNISOLONE ACETATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-1912 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA AUTHORIZED GENERIC 18 sections
PREDNISOLONE ACETATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-5275 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA AUTHORIZED GENERIC 18 sections
PREDNISOLONE ACETATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-5275 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA AUTHORIZED GENERIC 18 sections
Flo-Pred HUMAN PRESCRIPTION DRUG LABEL 1 51672-1338 SUSPENSION 16.70 mg ORAL NDA 25 sections
PREDNISOLONE ACETATE HUMAN PRESCRIPTION DRUG LABEL 1 52959-265 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA authorized generic 18 sections
BLEPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 2 54868-0634 SUSPENSION/ DROPS 2 mg OPHTHALMIC NDA 21 sections
BLEPHAMIDE HUMAN PRESCRIPTION DRUG LABEL 2 54868-1157 OINTMENT 2 mg OPHTHALMIC ANDA 19 sections
Prednisolone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 54868-4293 SUSPENSION 10 mg OPHTHALMIC NDA authorized generic 17 sections
PRED MILD HUMAN PRESCRIPTION DRUG LABEL 1 54868-6355 SUSPENSION/ DROPS 1.20 mg OPHTHALMIC NDA 18 sections
PREDNISOLONE ACETATE HUMAN PRESCRIPTION DRUG LABEL 1 60758-119 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA AUTHORIZED GENERIC 19 sections
PREDNISOLONE ACETATE HUMAN PRESCRIPTION DRUG LABEL 1 60758-119 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA AUTHORIZED GENERIC 19 sections
Prednisolone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 61314-637 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA authorized generic 18 sections
Prednisolone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 61314-637 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA authorized generic 18 sections
PREDNISOLONE ACETATE HUMAN PRESCRIPTION DRUG LABEL 1 68071-2222 SUSPENSION/ DROPS 10 mg OPHTHALMIC NDA authorized generic 19 sections
Prednisolone Acetate PF HUMAN PRESCRIPTION DRUG LABEL 1 70261-501 SUSPENSION/ DROPS 10 mg OPHTHALMIC unapproved drug other 2 sections
Pred-Gati HUMAN PRESCRIPTION DRUG LABEL 2 70261-502 SUSPENSION 10 mg OPHTHALMIC unapproved drug other 2 sections
Pred-Gati-Brom HUMAN PRESCRIPTION DRUG LABEL 3 70261-504 SUSPENSION/ DROPS 10 mg OPHTHALMIC unapproved drug other 2 sections
Pred-Brom HUMAN PRESCRIPTION DRUG LABEL 2 70261-505 SUSPENSION/ DROPS 10 mg OPHTHALMIC unapproved drug other 2 sections