prednicarbate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2243 73771-04-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednicarbate
  • prednitop
  • Molecular weight: 488.58
  • Formula: C27H36O8
  • CLOGP: 3.50
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 116.20
  • ALOGS: -4.94
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.22 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Sept. 23, 1991 FDA VALEANT PHARMS NORTH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ecthyma 52.66 51.38 7 293 291 63488431

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AC18 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:49103 drug metabolites
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Telangiectasia disorder contraindication 247479008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.19 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4020905 VUID
N0000148395 NUI
D05601 KEGG_DRUG
4017988 VANDF
4020905 VANDF
C0071836 UMLSCUI
CHEBI:135791 CHEBI
CHEBI:8378 CHEBI
TUA PDB_CHEM_ID
CHEMBL1200386 ChEMBL_ID
DB01130 DRUGBANK_ID
C035287 MESH_SUPPLEMENTAL_RECORD_UI
7605 IUPHAR_LIGAND_ID
4968 INN_ID
V901LV1K7D UNII
6714002 PUBCHEM_CID
DB00860 DRUGBANK_ID
34369 RXNORM
5346 MMSL
5347 MMSL
59710 MMSL
89095 MMSL
d00084 MMSL
002155 NDDF
004400 NDDF
116601002 SNOMEDCT_US
126086006 SNOMEDCT_US
415158006 SNOMEDCT_US
52388000 SNOMEDCT_US
C0032950 UMLSCUI
535 INN_ID
5755 PUBCHEM_CID
D011239 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Prednicarbate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0410 OINTMENT 1 mg TOPICAL ANDA 20 sections
Prednicarbate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0410 OINTMENT 1 mg TOPICAL ANDA 20 sections