octatropine methylbromide indications/contra

Stem definitionDrug idCAS RN
atropine derivatives 223 80-50-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • octatropine methylbromide
  • anisotropine methylbromide
  • anisotropine methobromide
  • anisotropine methyl bromide
  • valpin
minor descriptor (65-86); on line & INDEX MEDICUS search TROPANES (69-86); RN given refers to endo-isomer
  • Molecular weight: 282.45
  • Formula: C17H32NO2
  • CLOGP: -0.82
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 26.30
  • ALOGS: -6.61
  • ROTB: 7

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 23, 1962 FDA ENDO PHARMS

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:50370 parasympatholytic

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Gastric ulcer indication 397825006 DOID:10808
Irritable bowel syndrome off-label use 10743008 DOID:9778

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST DRUGBANK CHEMBL
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST DRUGBANK CHEMBL

External reference:

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IDSource
DB00517 DRUGBANK_ID
4018547 VUID
N0000179041 NUI
C0051923 UMLSCUI
62M960DHIL UNII
913 INN_ID
657201 PUBCHEM_CID
4018547 VANDF
17945 RXNORM
N0000146869 NDFRT
N0000179041 NDFRT
367554003 SNOMEDCT_US
400569008 SNOMEDCT_US
001748 NDDF
CHEBI:2739 CHEBI
CHEMBL1578 ChEMBL_ID
C100237 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None