anisindione indications/contra

Stem definitionDrug idCAS RN
222 117-37-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anisindione
  • andion
  • miradon
  • unidone
a synthetic anticoagulant it exercises its therapeutic action by reducing the prothrombin activity of the blood by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins
  • Molecular weight: 252.27
  • Formula: C16H12O3
  • CLOGP: 2.73
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -4.30
  • ROTB: 2

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
April 5, 1957 FDA SCHERING

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
CHEBI has role CHEBI:50249 anticoagulant

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.96 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin K-dependent gamma-carboxylase Enzyme INHIBITOR DRUGBANK CHEMBL
Arachidonate 5-lipoxygenase Enzyme IC50 5.04 CHEMBL

External reference:

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IDSource
4018805 VUID
N0000147108 NUI
C0051919 UMLSCUI
6960 IUPHAR_LIGAND_ID
D07457 KEGG_DRUG
DB01125 DRUGBANK_ID
CHEMBL712 ChEMBL_ID
2197 PUBCHEM_CID
4018805 VANDF
N0000006748 NDFRT
N0000147108 NDFRT
d00519 MMSL
4203 MMSL
17941 RXNORM
38122009 SNOMEDCT_US
397228002 SNOMEDCT_US
002091 NDDF
CHEBI:133809 CHEBI
S747T1ERAJ UNII
854 INN_ID
C010679 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None