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pirlindole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2206 | 60762-57-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 25 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,IRAK4,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 49 | |||
| kinase-selectivity-class | AXL,EIF2AK3,PRKCZ,TTK | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D008996 | Monoamine Oxidase Inhibitors |
| MeSH PA | D011619 | Psychotropic Drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Depressive disorder | indication | 35489007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.43 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] A | Enzyme | INHIBITOR | Ki | 7.41 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Transcriptional enhancer factor TEF-1 | Transcription factor | Kd | 4.92 | CHEMBL | |||||
| Transcriptional enhancer factor TEF-3 | Transcription factor | IC50 | 4.44 | CHEMBL | |||||
| Transcriptional enhancer factor TEF-4 | Transcription factor | IC50 | 4.48 | CHEMBL | |||||
| Transcriptional enhancer factor TEF-5 | Transcription factor | IC50 | 4.36 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D08392 | KEGG_DRUG |
| 16154-78-2 | SECONDARY_CAS_RN |
| C0071143 | UMLSCUI |
| CHEBI:748117 | CHEBI |
| CHEMBL32350 | ChEMBL_ID |
| DB09244 | DRUGBANK_ID |
| 68802 | PUBCHEM_CID |
| C009830 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6638 | IUPHAR_LIGAND_ID |
| 4615 | INN_ID |
| 207572-66-5 | SECONDARY_CAS_RN |
| V39YPH45FZ | UNII |
| V39YPH45FZ | INXIGHT DRUGS |
Pharmaceutical products:
None