anileridine indications/contra

Stem definitionDrug idCAS RN
analgesics, pethidine derivatives 220 144-14-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anileridine
  • adopol
  • alidine
  • apidol
  • leritin
  • leritine
  • nipecotan
  • anileridine hydrochloride
  • anileridine phosphate
  • anileridine HCl
  • anileridine monohydrochloride
  • anileridine dihydrochloride
minor descriptor (64-86); on line & INDEX MEDICUS search ISONIPECOTIC ACIDS (68-86); RN given refers to parent cpd
  • Molecular weight: 352.48
  • Formula: C22H28N2O2
  • CLOGP: 3.10
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 55.56
  • ALOGS: -4.46
  • ROTB: 7

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA MERCK

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N01AH05 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Opioid anesthetics
CHEBI has role CHEBI:60606 opioid receptor agonist
CHEBI has role CHEBI:35482 opioid analgesic

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.29 Basic
pKa2 3.44 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST WOMBAT-PK CHEMBL

External reference:

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IDSource
C0051908 UMLSCUI
7115 IUPHAR_LIGAND_ID
D02941 KEGG_DRUG
3584484N8V UNII
1976-75-6 SECONDARY_CAS_RN
528 INN_ID
DB00913 DRUGBANK_ID
17933 RXNORM
55793008 SNOMEDCT_US
001560 NDDF
8944 PUBCHEM_CID
CHEMBL1200543 ChEMBL_ID
CHEMBL1201047 ChEMBL_ID
CHEMBL1201347 ChEMBL_ID
C100232 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:61203 CHEBI

Pharmaceutical products:

None