anhydrovinblastine indications/contra

Stem definitionDrug idCAS RN
vinca alkaloids 219 38390-45-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anhydrovinblastine
  • anhydrovincaleukoblastine
  • Molecular weight: 792.97
  • Formula: C46H56N4O8
  • CLOGP: 6.11
  • LIPINSKI: 3
  • HAC: 12
  • HDO: 2
  • TPSA: 133.87
  • ALOGS: -5.01
  • ROTB: 10

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1965 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.32 acidic
pKa2 13.81 acidic
pKa3 7.58 Basic
pKa4 6.94 Basic
pKa5 6.11 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tubulin beta-4B chain Structural WOMBAT-PK
Multidrug resistance-associated protein 7 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance protein 1 Transporter WOMBAT-PK

External reference:

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IDSource
5B622U08B3 UNII
443324 PUBCHEM_CID
DB12586 DRUGBANK_ID
CHEBI:1322 CHEBI

Pharmaceutical products:

None