pipemidic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 2184 51940-44-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pipemidic acid
  • pipeacid
  • uropimid
Antimicrobial against Gram negative and some Gram positive bacteria. It is protein bound and concentrated in bile and urine and used for gastrointestinal, biliary, and urinary infections.
  • Molecular weight: 303.32
  • Formula: C14H17N5O3
  • CLOGP: -2.23
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 98.66
  • ALOGS: -2.61
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.80 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.88 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.84 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.69 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MB04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Other quinolones
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:59517 DNA synthesis inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.55 acidic
pKa2 8.04 Basic
pKa3 6.43 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167334 NUI
D08379 KEGG_DRUG
C0031953 UMLSCUI
CHEBI:75250 CHEBI
CHEMBL30116 ChEMBL_ID
DB13823 DRUGBANK_ID
D010876 MESH_DESCRIPTOR_UI
4831 PUBCHEM_CID
12774 IUPHAR_LIGAND_ID
3694 INN_ID
LT12J5HVR8 UNII
8337 RXNORM
004201 NDDF
702807004 SNOMEDCT_US
96079005 SNOMEDCT_US

Pharmaceutical products:

None