anecortave indications/contra

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 217 7753-60-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anecortave acetate
  • anecortave
  • retaane
  • Molecular weight: 386.49
  • Formula: C23H30O5
  • CLOGP: 2.87
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 80.67
  • ALOGS: -4.53
  • ROTB: 4

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 2006 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC S01LA02 SENSORY ORGANS
OPHTHALMOLOGICALS
OCULAR VASCULAR DISORDER AGENTS
Antineovascularisation agents
MeSH PA D020533 Angiogenesis Inhibitors
MeSH PA D043924 Angiogenesis Modulating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D006131 Growth Inhibitors
MeSH PA D006133 Growth Substances

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Exudative age-related macular degeneration indication 414173003 DOID:10873

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.5 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Plasminogen activator inhibitor 1 Secreted WOMBAT-PK

External reference:

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IDSource
D01733 KEGG_DRUG
011285 NDDF
111332 PUBCHEM_CID
C108424 MESH_SUPPLEMENTAL_RECORD_UI
C418047 MESH_SUPPLEMENTAL_RECORD_UI
DB05288 DRUGBANK_ID
CHEMBL2106613 ChEMBL_ID
R5Y8O51589 UNII
10184-70-0 SECONDARY_CAS_RN
DB12081 DRUGBANK_ID
7747 INN_ID
CHEBI:31215 CHEBI

Pharmaceutical products:

None