phthalylsulfathiazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2158 85-73-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phthalylsulfathiazole
  • cremothalidine
  • enteramida
  • entexidina
  • phtalazol
  • phthalazol
  • phthalylnorsulfazole
  • phthalylsulfonazole
  • phthalylsulphathiazole
  • sulfaphthalazole
  • sulfathalidine
  • sulphaphthalyl
  • phthalylsulfathiazole sodium
  • phthalylsulfathiazole monosodium salt
minor descriptor (63-86); on-line & INDEX MEDICUS search SULFATHIAZOLES (66-86); RN given refers to parent cpd
  • Molecular weight: 403.43
  • Formula: C17H13N3O5S2
  • CLOGP: 1.25
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 125.46
  • ALOGS: -4.37
  • ROTB: 5

Drug dosage:

DoseUnitRoute
9 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 5357.59 362.19 3756 124352 179970 63180944
Systemic lupus erythematosus 4820.72 362.19 3709 124399 205209 63155705
Glossodynia 4510.04 362.19 3350 124758 175526 63185388
Abdominal discomfort 3649.28 362.19 3821 124287 317064 63043850
Hand deformity 3608.37 362.19 2802 125306 156655 63204259
Alopecia 3536.08 362.19 3848 124260 333688 63027226
Wound 3009.11 362.19 2546 125562 160717 63200197
Arthropathy 2552.09 362.19 2734 125374 232058 63128856
Swelling 2500.86 362.19 2919 125189 272459 63088455
Contraindicated product administered 2499.33 362.19 2610 125498 215038 63145876
Discomfort 2390.17 362.19 2261 125847 165113 63195801
Pericarditis 2366.88 362.19 2025 126083 129554 63231360
Anti-cyclic citrullinated peptide antibody positive 2243.01 362.19 1863 126245 114349 63246565
Maternal exposure during pregnancy 2218.48 362.19 2464 125644 217598 63143316
Product use issue 1823.36 362.19 2231 125877 218289 63142625
Synovitis 1735.75 362.19 2007 126101 184911 63176003
Rheumatoid factor positive 1612.25 362.19 1346 126762 83060 63277854
Infusion related reaction 1520.92 362.19 2156 125952 243365 63117549
Hepatic enzyme increased 1461.96 362.19 1915 126193 200413 63160501
Drug intolerance 1395.80 362.19 2343 125765 306318 63054596
Duodenal ulcer perforation 1353.74 362.19 1236 126872 85973 63274941
Helicobacter infection 1326.36 362.19 1256 126852 91529 63269385
Pain 1259.06 362.19 3797 124311 736831 62624083
Treatment failure 1106.32 362.19 1662 126446 197381 63163533
Hypersensitivity 1062.71 362.19 2020 126088 290665 63070249
Rheumatic fever 1048.50 362.19 793 127315 42318 63318596
Hip arthroplasty 915.40 362.19 763 127345 46883 63314031
Swollen joint count increased 914.04 362.19 680 127428 35374 63325540
Joint swelling 799.66 362.19 1925 126183 325741 63035173
Knee arthroplasty 778.05 362.19 736 127372 53470 63307444
Liver injury 767.96 362.19 768 127340 59752 63301162
Type 2 diabetes mellitus 760.32 362.19 783 127325 63085 63297829
Blood cholesterol increased 702.19 362.19 906 127202 93126 63267788
Fall 689.58 362.19 23 128085 392311 62968603
Death 654.22 362.19 23 128085 374358 62986556
Therapeutic product effect decreased 647.98 362.19 1291 126817 191896 63169018
Rheumatoid arthritis 603.16 362.19 1477 126631 252342 63108572
Blister 590.32 362.19 990 127118 128824 63232090
Psoriatic arthropathy 584.17 362.19 817 127291 90703 63270211
Rash 537.66 362.19 2394 125714 558477 62802437
General physical health deterioration 500.58 362.19 1193 126915 200209 63160705
Nausea 496.86 362.19 599 127509 853872 62507042
Back pain 472.77 362.19 13 128095 264132 63096782
Intentional product use issue 466.51 362.19 886 127222 127006 63233908
Musculoskeletal stiffness 454.81 362.19 1090 127018 183528 63177386
Hypotension 445.79 362.19 26 128082 272578 63088336
Fatigue 435.50 362.19 3166 124942 884862 62476052
Diarrhoea 435.32 362.19 483 127625 714883 62646031
Folliculitis 423.85 362.19 611 127497 69706 63291208
Muscle injury 407.37 362.19 577 127531 64768 63296146

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 3248.47 422.55 1692 76487 97890 79568319
Systemic lupus erythematosus 2926.78 422.55 1688 76491 119461 79546748
Glossodynia 2870.15 422.55 1578 76601 101759 79564450
Hand deformity 2730.15 422.55 1530 76649 102389 79563820
Pericarditis 2112.58 422.55 1298 76881 102938 79563271
Alopecia 2065.41 422.55 1749 76430 229606 79436603
Anti-cyclic citrullinated peptide antibody positive 2062.86 422.55 1180 76999 81963 79584246
Wound 2010.29 422.55 1309 76870 114870 79551339
Abdominal discomfort 1890.10 422.55 1722 76457 249005 79417204
Arthropathy 1671.96 422.55 1384 76795 175727 79490482
Synovitis 1667.78 422.55 1293 76886 149441 79516768
Swelling 1666.71 422.55 1506 76673 215205 79451004
Discomfort 1662.61 422.55 1200 76979 124417 79541792
Contraindicated product administered 1473.62 422.55 1225 76954 156313 79509896
Rheumatoid factor positive 1447.63 422.55 836 77343 59003 79607206
Maternal exposure during pregnancy 1414.32 422.55 1127 77052 135411 79530798
Drug intolerance 1359.74 422.55 1475 76704 262644 79403565
Duodenal ulcer perforation 1330.87 422.55 821 77358 65390 79600819
Hepatic enzyme increased 1286.07 422.55 1209 76970 181401 79484808
Helicobacter infection 1269.64 422.55 812 77367 68892 79597317
Infusion related reaction 1109.94 422.55 1243 76936 228994 79437215
Hypersensitivity 1074.27 422.55 1302 76877 260937 79405272
Rheumatic fever 891.11 422.55 472 77707 28053 79638156
Treatment failure 887.61 422.55 959 77220 169527 79496682
Joint swelling 866.11 422.55 1230 76949 287416 79378793
Product use issue 858.81 422.55 1042 77137 208780 79457429
Hip arthroplasty 796.73 422.55 474 77705 35282 79630927
Blister 792.30 422.55 766 77413 118710 79547499
Therapeutic product effect decreased 790.88 422.55 886 77293 162977 79503232
Swollen joint count increased 729.17 422.55 384 77795 22543 79643666
Knee arthroplasty 670.66 422.55 456 77723 42792 79623417
Folliculitis 593.34 422.55 467 77712 54913 79611296
Blood cholesterol increased 583.55 422.55 552 77627 83168 79583041
Type 2 diabetes mellitus 578.45 422.55 466 77713 56656 79609553
Muscle injury 569.30 422.55 432 77747 48129 79618080
Pain 558.16 422.55 1731 76448 702071 78964138
Irritable bowel syndrome 487.24 422.55 438 77741 61803 79604406
Death 480.99 422.55 17 78162 566497 79099712
Fibromyalgia 463.15 422.55 432 77747 63908 79602301
Musculoskeletal stiffness 457.62 422.55 700 77479 174308 79491901
Liver injury 454.22 422.55 404 77775 56210 79609999
Sleep disorder due to general medical condition, insomnia type 435.94 422.55 353 77826 43203 79623006

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AB02 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Sulfonamides

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.73 acidic
pKa2 6.8 acidic
pKa3 13.12 acidic
pKa4 1.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02440 KEGG_DRUG
C0070975 UMLSCUI
CHEBI:9336 CHEBI
CHEMBL1524273 ChEMBL_ID
DB13248 DRUGBANK_ID
C100300 MESH_SUPPLEMENTAL_RECORD_UI
4806 PUBCHEM_CID
4175 INN_ID
6875L5852V UNII
33632 RXNORM
002838 NDDF
16359004 SNOMEDCT_US

Pharmaceutical products:

None