phthalylsulfathiazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-infectives, sulfonamides	2158	85-73-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: phthalylsulfathiazole cremothalidine enteramida entexidina phtalazol phthalazol phthalylnorsulfazole phthalylsulfonazole phthalylsulphathiazole sulfaphthalazole sulfathalidine sulphaphthalyl phthalylsulfathiazole sodium phthalylsulfathiazole monosodium salt	minor descriptor (63-86); on-line & INDEX MEDICUS search SULFATHIAZOLES (66-86); RN given refers to parent cpd Molecular weight: 403.43 Formula: C17H13N3O5S2 CLOGP: 1.25 LIPINSKI: 0 HAC: 8 HDO: 3 TPSA: 125.46 ALOGS: -4.37 ROTB: 5

Molecule

Description

Molfile Inchi Smiles

Synonyms:

phthalylsulfathiazole
cremothalidine
enteramida
entexidina
phtalazol
phthalazol
phthalylnorsulfazole
phthalylsulfonazole
phthalylsulphathiazole
sulfaphthalazole
sulfathalidine
sulphaphthalyl
phthalylsulfathiazole sodium
phthalylsulfathiazole monosodium salt

minor descriptor (63-86); on-line & INDEX MEDICUS search SULFATHIAZOLES (66-86); RN given refers to parent cpd

Molecular weight: 403.43
Formula: C17H13N3O5S2
CLOGP: 1.25
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 125.46
ALOGS: -4.37
ROTB: 5

Drug dosage:

Dose	Unit	Route
9	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	5357.59	362.19	3756	124352	179970	63180944
Systemic lupus erythematosus	4820.72	362.19	3709	124399	205209	63155705
Glossodynia	4510.04	362.19	3350	124758	175526	63185388
Abdominal discomfort	3649.28	362.19	3821	124287	317064	63043850
Hand deformity	3608.37	362.19	2802	125306	156655	63204259
Alopecia	3536.08	362.19	3848	124260	333688	63027226
Wound	3009.11	362.19	2546	125562	160717	63200197
Arthropathy	2552.09	362.19	2734	125374	232058	63128856
Swelling	2500.86	362.19	2919	125189	272459	63088455
Contraindicated product administered	2499.33	362.19	2610	125498	215038	63145876
Discomfort	2390.17	362.19	2261	125847	165113	63195801
Pericarditis	2366.88	362.19	2025	126083	129554	63231360
Anti-cyclic citrullinated peptide antibody positive	2243.01	362.19	1863	126245	114349	63246565
Maternal exposure during pregnancy	2218.48	362.19	2464	125644	217598	63143316
Product use issue	1823.36	362.19	2231	125877	218289	63142625
Synovitis	1735.75	362.19	2007	126101	184911	63176003
Rheumatoid factor positive	1612.25	362.19	1346	126762	83060	63277854
Infusion related reaction	1520.92	362.19	2156	125952	243365	63117549
Hepatic enzyme increased	1461.96	362.19	1915	126193	200413	63160501
Drug intolerance	1395.80	362.19	2343	125765	306318	63054596
Duodenal ulcer perforation	1353.74	362.19	1236	126872	85973	63274941
Helicobacter infection	1326.36	362.19	1256	126852	91529	63269385
Pain	1259.06	362.19	3797	124311	736831	62624083
Treatment failure	1106.32	362.19	1662	126446	197381	63163533
Hypersensitivity	1062.71	362.19	2020	126088	290665	63070249
Rheumatic fever	1048.50	362.19	793	127315	42318	63318596
Hip arthroplasty	915.40	362.19	763	127345	46883	63314031
Swollen joint count increased	914.04	362.19	680	127428	35374	63325540
Joint swelling	799.66	362.19	1925	126183	325741	63035173
Knee arthroplasty	778.05	362.19	736	127372	53470	63307444
Liver injury	767.96	362.19	768	127340	59752	63301162
Type 2 diabetes mellitus	760.32	362.19	783	127325	63085	63297829
Blood cholesterol increased	702.19	362.19	906	127202	93126	63267788
Fall	689.58	362.19	23	128085	392311	62968603
Death	654.22	362.19	23	128085	374358	62986556
Therapeutic product effect decreased	647.98	362.19	1291	126817	191896	63169018
Rheumatoid arthritis	603.16	362.19	1477	126631	252342	63108572
Blister	590.32	362.19	990	127118	128824	63232090
Psoriatic arthropathy	584.17	362.19	817	127291	90703	63270211
Rash	537.66	362.19	2394	125714	558477	62802437
General physical health deterioration	500.58	362.19	1193	126915	200209	63160705
Nausea	496.86	362.19	599	127509	853872	62507042
Back pain	472.77	362.19	13	128095	264132	63096782
Intentional product use issue	466.51	362.19	886	127222	127006	63233908
Musculoskeletal stiffness	454.81	362.19	1090	127018	183528	63177386
Hypotension	445.79	362.19	26	128082	272578	63088336
Fatigue	435.50	362.19	3166	124942	884862	62476052
Diarrhoea	435.32	362.19	483	127625	714883	62646031
Folliculitis	423.85	362.19	611	127497	69706	63291208
Muscle injury	407.37	362.19	577	127531	64768	63296146

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	3248.47	422.55	1692	76487	97890	79568319
Systemic lupus erythematosus	2926.78	422.55	1688	76491	119461	79546748
Glossodynia	2870.15	422.55	1578	76601	101759	79564450
Hand deformity	2730.15	422.55	1530	76649	102389	79563820
Pericarditis	2112.58	422.55	1298	76881	102938	79563271
Alopecia	2065.41	422.55	1749	76430	229606	79436603
Anti-cyclic citrullinated peptide antibody positive	2062.86	422.55	1180	76999	81963	79584246
Wound	2010.29	422.55	1309	76870	114870	79551339
Abdominal discomfort	1890.10	422.55	1722	76457	249005	79417204
Arthropathy	1671.96	422.55	1384	76795	175727	79490482
Synovitis	1667.78	422.55	1293	76886	149441	79516768
Swelling	1666.71	422.55	1506	76673	215205	79451004
Discomfort	1662.61	422.55	1200	76979	124417	79541792
Contraindicated product administered	1473.62	422.55	1225	76954	156313	79509896
Rheumatoid factor positive	1447.63	422.55	836	77343	59003	79607206
Maternal exposure during pregnancy	1414.32	422.55	1127	77052	135411	79530798
Drug intolerance	1359.74	422.55	1475	76704	262644	79403565
Duodenal ulcer perforation	1330.87	422.55	821	77358	65390	79600819
Hepatic enzyme increased	1286.07	422.55	1209	76970	181401	79484808
Helicobacter infection	1269.64	422.55	812	77367	68892	79597317
Infusion related reaction	1109.94	422.55	1243	76936	228994	79437215
Hypersensitivity	1074.27	422.55	1302	76877	260937	79405272
Rheumatic fever	891.11	422.55	472	77707	28053	79638156
Treatment failure	887.61	422.55	959	77220	169527	79496682
Joint swelling	866.11	422.55	1230	76949	287416	79378793
Product use issue	858.81	422.55	1042	77137	208780	79457429
Hip arthroplasty	796.73	422.55	474	77705	35282	79630927
Blister	792.30	422.55	766	77413	118710	79547499
Therapeutic product effect decreased	790.88	422.55	886	77293	162977	79503232
Swollen joint count increased	729.17	422.55	384	77795	22543	79643666
Knee arthroplasty	670.66	422.55	456	77723	42792	79623417
Folliculitis	593.34	422.55	467	77712	54913	79611296
Blood cholesterol increased	583.55	422.55	552	77627	83168	79583041
Type 2 diabetes mellitus	578.45	422.55	466	77713	56656	79609553
Muscle injury	569.30	422.55	432	77747	48129	79618080
Pain	558.16	422.55	1731	76448	702071	78964138
Irritable bowel syndrome	487.24	422.55	438	77741	61803	79604406
Death	480.99	422.55	17	78162	566497	79099712
Fibromyalgia	463.15	422.55	432	77747	63908	79602301
Musculoskeletal stiffness	457.62	422.55	700	77479	174308	79491901
Liver injury	454.22	422.55	404	77775	56210	79609999
Sleep disorder due to general medical condition, insomnia type	435.94	422.55	353	77826	43203	79623006

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A07AB02	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFECTIVES Sulfonamides

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.73	acidic
pKa2	6.8	acidic
pKa3	13.12	acidic
pKa4	1.61	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D02440	KEGG_DRUG
C0070975	UMLSCUI
CHEBI:9336	CHEBI
CHEMBL1524273	ChEMBL_ID
DB13248	DRUGBANK_ID
C100300	MESH_SUPPLEMENTAL_RECORD_UI
4806	PUBCHEM_CID
4175	INN_ID
6875L5852V	UNII
33632	RXNORM
002838	NDDF
16359004	SNOMEDCT_US

Pharmaceutical products:

None