androstenedione indications/contra
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids, androgens | 215 | 63-05-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
|
Drug dosage:
Approvals:
None
FDA Adverse Event Reporting System
None
Pharmacologic Action:
None
Drug Use (View source of the data)
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) |
Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Aromatase | Enzyme | Ki | 7.70 | CHEMBL | |||||
| Sex hormone-binding globulin | Secreted | Kd | 7.46 | CHEMBL | |||||
| Testosterone 17-beta-dehydrogenase 3 | Enzyme | IC50 | 6.31 | CHEMBL | |||||
| Corticosteroid-binding globulin | Secreted | Ki | 5.76 | CHEMBL | |||||
| Androgen receptor | Transcription factor | IC50 | 5.89 | CHEMBL | |||||
| Testosterone 17-beta-dehydrogenase 3 | Unclassified | IC50 | 6.77 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 2860 | IUPHAR_LIGAND_ID |
| 4021377 | VUID |
| N0000148795 | NUI |
| C0002860 | UMLSCUI |
| D00051 | KEGG_DRUG |
| CHEMBL274826 | ChEMBL_ID |
| 409J2J96VR | UNII |
| 6128 | PUBCHEM_CID |
| 784 | RXNORM |
| 56146000 | SNOMEDCT_US |
| 4021377 | VANDF |
| N0000010065 | NDFRT |
| N0000148795 | NDFRT |
| 011070 | NDDF |
| CHEBI:16422 | CHEBI |
| C042013 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB01536 | DRUGBANK_ID |
| D000735 | MESH_DESCRIPTOR_UI |
| ASD | PDB_CHEM_ID |
Pharmaceutical products:
None