androstenediol indications/contra

Stem definitionDrug idCAS RN
steroids, androgens 214 521-17-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • androstenediol
  • Androst-5-enediol
  • hermaphrodiol
An intermediate in TESTOSTERONE biosynthesis, found in the TESTIS or the ADRENAL GLANDS. Androstenediol, derived from DEHYDROEPIANDROSTERONE by the reduction of the 17-keto group (17-HYDROXYSTEROID DEHYDROGENASES), is converted to TESTOSTERONE by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-HYDROXYSTEROID DEHYDROGENASES).
  • Molecular weight: 290.45
  • Formula: C19H30O2
  • CLOGP: 3.47
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -3.72
  • ROTB: 0

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
MeSH PA D045930 Anabolic Agents
MeSH PA D006728 Hormones
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Estrogen receptor Nuclear hormone receptor IC50 6.74 CHEMBL
Sex hormone-binding globulin Secreted Kd 9.17 CHEMBL
Estrogen receptor beta Nuclear hormone receptor IC50 8 CHEMBL
Androgen receptor Nuclear hormone receptor IC50 6.64 CHEMBL
Corticosteroid-binding globulin Secreted Ki 5 CHEMBL
Androgen receptor Transcription factor IC50 5.86 CHEMBL

External reference:

scroll-->
IDSource
D00179 KEGG_DRUG
CHEMBL440283 ChEMBL_ID
10634 PUBCHEM_CID
N0000167518 NDFRT
103051007 SNOMEDCT_US
95PS51EMXY UNII
CHEBI:2710 CHEBI
DB01524 DRUGBANK_ID
D015114 MESH_DESCRIPTOR_UI
B81 PDB_CHEM_ID

Pharmaceutical products:

None