phenolphthalein indications/contra

Stem definitionDrug idCAS RN
2135 77-09-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phenolphthalein
  • euchessina
  • phthalimetten
  • phthalin
An acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. It is used medicinally as a cathartic.
  • Molecular weight: 318.33
  • Formula: C20H14O4
  • CLOGP: 2.58
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 66.76
  • ALOGS: -4.51
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.20 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A06AB04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Contact laxatives
MeSH PA D007202 Indicators and Reagents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Incontinence of feces contraindication 72042002
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal obstruction contraindication 126765001
Constipation off-label use 14760008 DOID:2089
Incomplete passage of stool off-label use 249515001

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.45 acidic
pKa2 10.06 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thymidylate synthase Enzyme Ki 5.92 CHEMBL
Thymidylate synthase Enzyme Ki 5.33 CHEMBL
Thymidylate synthase Enzyme Ki 5.85 CHEMBL
Thymidylate synthase Enzyme Ki 5.33 CHEMBL

External reference:

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IDSource
4020931 VUID
N0000148413 NUI
C0600489 UMLSCUI
D05456 KEGG_DRUG
6QK969R2IF UNII
4575 INN_ID
CHEMBL63857 ChEMBL_ID
155122 RXNORM
19595005 SNOMEDCT_US
398955002 SNOMEDCT_US
5275 MMSL
d01012 MMSL
4020338 VANDF
4018930 VANDF
4020931 VANDF
71908 MMSL
N0000006578 NDFRT
N0000147222 NDFRT
N0000148180 NDFRT
N0000148413 NDFRT
001174 NDDF
4764 PUBCHEM_CID
DB04824 DRUGBANK_ID
D020113 MESH_DESCRIPTOR_UI
CHEBI:34914 CHEBI

Pharmaceutical products:

None