phenmetrazine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anorexics 2133 134-49-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phenmetrazine teoclate
  • fenmetrazine
  • phenmetrazine hydrochloride
  • phenmetrazine
  • 3-Methyl-2-phenylmorpholine
  • 3-Methyl-2-phenyltetrahydro-2H-1,4-oxazine
  • oxazimedrine
  • phenmetrazin
  • fenmetrazina
  • phenmetrazine HCl
A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.
  • Molecular weight: 177.25
  • Formula: C11H15NO
  • CLOGP: 1.47
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -1.86
  • ROTB: 1

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 0 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 19 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.04 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
None FDA BOEHRINGER INGELHEIM

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D019440 Anti-Obesity Agents
MeSH PA D001067 Appetite Depressants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:35524 sympathomimetic

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Obesity indication 414916001 DOID:9970
Heart valve disorder contraindication 368009 DOID:4079
Alcoholism contraindication 7200002
Glaucoma contraindication 23986001 DOID:1686
Feeling agitated contraindication 24199005
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Conduction disorder of the heart contraindication 44808001
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Chronic heart failure contraindication 48447003
Substance abuse contraindication 66214007
Pulmonary hypertension contraindication 70995007 DOID:6432
Arteriosclerotic vascular disease contraindication 72092001
Epilepsy contraindication 84757009 DOID:1826
Drug-induced psychosis contraindication 191483003 DOID:1742
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Hypertensive urgency contraindication 443482000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.81 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter INHIBITOR EC50 7.30 WOMBAT-PK CHEMBL
Sodium-dependent dopamine transporter Transporter INHIBITOR EC50 6.88 WOMBAT-PK CHEMBL
Amine oxidase [flavin-containing] A Enzyme WOMBAT-PK

External reference:

IDSource
4019065 VUID
N0000179644 NUI
D05454 KEGG_DRUG
13931-75-4 SECONDARY_CAS_RN
13580-35-3 SECONDARY_CAS_RN
4019065 VANDF
4019889 VANDF
C0031411 UMLSCUI
CHEBI:8068 CHEBI
CHEMBL1201208 ChEMBL_ID
DB00830 DRUGBANK_ID
CHEMBL1200483 ChEMBL_ID
D010633 MESH_DESCRIPTOR_UI
4762 PUBCHEM_CID
553 INN_ID
XA501VL3VR UNII
203198 RXNORM
001868 NDDF
004774 NDDF
23532003 SNOMEDCT_US
387127002 SNOMEDCT_US
387462002 SNOMEDCT_US
1618-50-4 SECONDARY_CAS_RN

Pharmaceutical products:

None