pheniprazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
monoamine oxidase inhibitors, hydrazine derivatives 2131 55-52-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • beta-phenylisopropylhydrazine
  • pheniprazine
  • 1-phenyl-2-hydrazinopropane
  • phenizine
  • pheniprazine hydrochloride
  • pheniprazine HCl
  • Molecular weight: 150.23
  • Formula: C9H14N2
  • CLOGP: 1.34
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 38.05
  • ALOGS: -1.60
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PIM2,PRKCD,PRKDC,SIK2,SIK3,SYK,TEK,TGFBR1 38
kinase-selectivity-class AKT2,AKT3,AXL,EIF2AK3,EPHB4,FLT3,GRK2,PAK4,PDK4,PRKCD,SIK2 11
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.7 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Amine oxidase [flavin-containing] A Enzyme INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Amine oxidase [flavin-containing] B Enzyme INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
C0031407 UMLSCUI
CHEBI:134773 CHEBI
CHEMBL22498 ChEMBL_ID
DB09250 DRUGBANK_ID
CHEMBL2106542 ChEMBL_ID
5929 PUBCHEM_CID
981 INN_ID
C084776 MESH_SUPPLEMENTAL_RECORD_UI
66-05-7 SECONDARY_CAS_RN
37VKD7067M UNII

Pharmaceutical products:

None