phenindione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2130 | 83-12-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 14.98 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 97 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | SANOFI AVENTIS US |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | B01AA02 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Vitamin K antagonists |
| MeSH PA | D000925 | Anticoagulants |
| MeSH PA | D006401 | Hematologic Agents |
| CHEBI has role | CHEBI:50249 | anticoagulants |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.43 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin K epoxide reductase complex subunit 1 | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
| Prothrombin | Enzyme | WOMBAT-PK | |||||||
| Arachidonate 5-lipoxygenase | Enzyme | IC50 | 4.82 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000007533 | NUI |
| D08354 | KEGG_DRUG |
| C0031406 | UMLSCUI |
| CHEBI:8066 | CHEBI |
| UAS | PDB_CHEM_ID |
| CHEMBL711 | ChEMBL_ID |
| DB00498 | DRUGBANK_ID |
| D010630 | MESH_DESCRIPTOR_UI |
| 4760 | PUBCHEM_CID |
| 6838 | IUPHAR_LIGAND_ID |
| 23 | INN_ID |
| 5M7Y6274ZE | UNII |
| 8130 | RXNORM |
| 002089 | NDDF |
| 387260007 | SNOMEDCT_US |
| 47527007 | SNOMEDCT_US |
Pharmaceutical products:
None