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phenelzine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2123	51-71-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: phenelzine 1-hydrazino-2-phenylethane 2-phenylethylhydrazine phenalzine phenethylhydrazine phenelzine sulfate	One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC. Molecular weight: 136.20 Formula: C8H12N2 CLOGP: 1.03 LIPINSKI: 0 HAC: 2 HDO: 2 TPSA: 38.05 ALOGS: -1.09 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

phenelzine
1-hydrazino-2-phenylethane
2-phenylethylhydrazine
phenalzine
phenethylhydrazine
phenelzine sulfate

One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.

Molecular weight: 136.20
Formula: C8H12N2
CLOGP: 1.03
LIPINSKI: 0
HAC: 2
HDO: 2
TPSA: 38.05
ALOGS: -1.09
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
60	mg	O

ADMET properties:

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Property	Value	Reference
S (Water solubility)	50 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

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Approvals:

Date	Agency	Company	Orphan
June 9, 1961	FDA	PARKE DAVIS

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Serotonin syndrome	120.94	35.41	36	1014	28646	63459326
Drug interaction	78.61	35.41	48	1002	229083	63258889
Product complaint	44.98	35.41	14	1036	12795	63475177
Hypertensive crisis	38.55	35.41	13	1037	15273	63472699
Food interaction	36.61	35.41	7	1043	831	63487141

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	46.64	42.89	39	355	456712	34499825

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Serotonin syndrome	135.79	31.66	42	1074	44985	79698287
Drug interaction	70.99	31.66	53	1063	415130	79328142
Drug dose titration not performed	31.66	31.66	6	1110	804	79742468

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	N06AF03	NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Monoamine oxidase inhibitors, non-selective
FDA EPC	N0000175744	Monoamine Oxidase Inhibitor
FDA MoA	N0000000184	Monoamine Oxidase Inhibitors
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D008996	Monoamine Oxidase Inhibitors
MeSH PA	D011619	Psychotropic Drugs

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Depressive disorder	indication	35489007
Bulimia nervosa	off-label use	78004001
Suicidal thoughts	contraindication	6471006
Alcoholism	contraindication	7200002
Bipolar disorder	contraindication	13746004	DOID:3312
Feeling agitated	contraindication	24199005
Orthostatic hypotension	contraindication	28651003
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Conduction disorder of the heart	contraindication	44808001

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.59	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Amine oxidase [flavin-containing] A	Enzyme	P21397	AOFA_HUMAN	INHIBITOR	IC50	6.84	DRUG MATRIX	CHEMBL
Amine oxidase [flavin-containing] B	Enzyme	P27338	AOFB_HUMAN	INHIBITOR	Ki	7.82	IUPHAR	CHEMBL
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6	DRUG MATRIX
Cytochrome P450 2C8	Enzyme	P10632	CP2C8_HUMAN	INHIBITOR	Ki	5.14	IUPHAR
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		IC50	5.40	DRUG MATRIX
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	6.10	DRUG MATRIX
Membrane primary amine oxidase	Enzyme	Q16853	AOC3_HUMAN		IC50	7.70	CHEMBL
Indoleamine 2,3-dioxygenase 1	Enzyme	P14902	I23O1_HUMAN		IC50	4.85	CHEMBL
Lysine-specific histone demethylase 1A	Enzyme	O60341	KDM1A_HUMAN		Ki	4.75	CHEMBL
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		IC50	5.70	DRUG MATRIX

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External reference:

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ID	Source
001495	NDDF
004596	NDDF
156-51-4	SECONDARY_CAS_RN
178818	MMSL
21614004	SNOMEDCT_US
3675	PUBCHEM_CID
387528000	SNOMEDCT_US
4018632	VANDF
4019886	VUID
4019886	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Nardil	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0350	TABLET, FILM COATED	15 mg	ORAL	NDA	19 sections
Phenelzine Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	40032-360	TABLET	15 mg	ORAL	ANDA	13 sections
Phenelzine Sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	43386-360	TABLET	15 mg	ORAL	ANDA	15 sections
phenelzine sulfate	HUMAN PRESCRIPTION DRUG LABEL	1	59762-0119	TABLET, FILM COATED	15 mg	ORAL	NDA AUTHORIZED GENERIC	20 sections

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