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phendimetrazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anorexics | 2122 | 634-03-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
minor descriptor (66-86); file maintained to MORPHOLINES (66-86); on-line & INDEX MEDICUS search MORPHOLINES (66-86); RN given refers to parent cpd without isomeric designation
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 0 | Hosey CM, Chan R, Benet LZ |
| S (Water solubility) | 17 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 28, 1976 | FDA | TG UNITED LABS |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sudden cardiac death | 93.38 | 53.54 | 13 | 141 | 2219 | 90626074 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sudden cardiac death | 94.76 | 41.44 | 15 | 188 | 5622 | 110583474 |
| Myocarditis | 42.30 | 41.44 | 10 | 193 | 30045 | 110559051 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA PE | N0000175372 | Appetite Suppression |
| FDA EPC | N0000175423 | Sympathomimetic Amine Anorectic |
| MeSH PA | D000697 | Central Nervous System Stimulants |
| MeSH PA | D002491 | Central Nervous System Agents |
| FDA PE | N0000175651 | Increased Sympathetic Activity |
| CHEBI has role | CHEBI:74518 | anti-obesity agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Obesity | indication | 414916001 | DOID:9970 |
| Heart valve disorder | contraindication | 368009 | DOID:4079 |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Feeling agitated | contraindication | 24199005 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Mild pre-eclampsia | contraindication | 41114007 | |
| Diabetes mellitus type 1 | contraindication | 46635009 | DOID:9744 |
| Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
| Substance abuse | contraindication | 66214007 | |
| Psychotic disorder | contraindication | 69322001 | |
| Pulmonary hypertension | contraindication | 70995007 | DOID:6432 |
| Arteriosclerotic vascular disease | contraindication | 72092001 | |
| Angina pectoris | contraindication | 194828000 | |
| Syncope | contraindication | 271594007 | |
| Hypertensive urgency | contraindication | 443482000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.77 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | CHEMBL | CHEMBL | |||||
| Sodium-dependent dopamine transporter | Transporter | INHIBITOR | CHEMBL | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Kd | 4.90 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018492 | VUID |
| N0000146814 | NUI |
| D02080 | KEGG_DRUG |
| 7635-51-0 | SECONDARY_CAS_RN |
| 50-58-8 | SECONDARY_CAS_RN |
| 4018491 | VANDF |
| 4018492 | VANDF |
| 4019885 | VANDF |
| C0070549 | UMLSCUI |
| CHEBI:8059 | CHEBI |
| CHEMBL1615439 | ChEMBL_ID |
| DB01579 | DRUGBANK_ID |
| CHEMBL2062163 | ChEMBL_ID |
| 30487 | PUBCHEM_CID |
| C100294 | MESH_SUPPLEMENTAL_RECORD_UI |
| 14332 | IUPHAR_LIGAND_ID |
| 982 | INN_ID |
| AB2794W8KV | UNII |
| 297716 | RXNORM |
| 2337 | MMSL |
| 5268 | MMSL |
| d00809 | MMSL |
| 001869 | NDDF |
| 001870 | NDDF |
| 001871 | NDDF |
| 26945002 | SNOMEDCT_US |
| 373340007 | SNOMEDCT_US |
| 39142008 | SNOMEDCT_US |
| AB2794W8KV | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-041 | TABLET | 35 mg | ORAL | ANDA | 12 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10702-045 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10702-077 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10702-078 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| phendimetrazine tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-028 | TABLET | 35 mg | ORAL | ANDA | 21 sections |
| phendimetrazine tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-539 | TABLET | 35 mg | ORAL | ANDA | 22 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-910 | CAPSULE, EXTENDED RELEASE | 105 mg | ORAL | NDA | 23 sections |
| PHENDIMETRAZINE TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-642 | TABLET | 35 mg | ORAL | ANDA | 11 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17224-500 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| PHENDIMETRAZINE TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17224-501 | TABLET | 35 mg | ORAL | ANDA | 16 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17224-800 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| PHENDIMETRAZINE TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17224-831 | CAPSULE, EXTENDED RELEASE | 105 mg | ORAL | NDA | 23 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-597 | TABLET | 35 mg | ORAL | ANDA | 10 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-341 | TABLET | 35 mg | ORAL | ANDA | 12 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-390 | CAPSULE, EXTENDED RELEASE | 105 mg | ORAL | NDA | 23 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-510 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0715 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2235 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2592 | TABLET | 35 mg | ORAL | ANDA | 16 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3976 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| PHENDIMETRAZINE TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5859 | TABLET | 35 mg | ORAL | ANDA | 16 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-6552 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-282 | TABLET | 35 mg | ORAL | ANDA | 12 sections |
| PHENDIMETRAZINE TARTRATEER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-886 | CAPSULE, EXTENDED RELEASE | 105 mg | ORAL | NDA | 12 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-0252 | TABLET | 35 mg | ORAL | ANDA | 13 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-3071 | CAPSULE, EXTENDED RELEASE | 105 mg | ORAL | NDA | 23 sections |
| PHENDIMETRAZINE TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61502-922 | TABLET | 35 mg | ORAL | ANDA | 12 sections |
| PHENDIMETRAZINE TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2489 | TABLET | 35 mg | ORAL | ANDA | 16 sections |
| PHENDIMETRAZINE TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 64850-440 | TABLET | 35 mg | ORAL | ANDA | 22 sections |
| Phendimetrazine Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66267-394 | TABLET | 35 mg | ORAL | ANDA | 12 sections |