phendimetrazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anorexics 2122 634-03-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phendimetrazine hydrochloride
  • phendimetrazine
  • (+)-Phendimetrazine
  • antapentan
  • mephenmetrazine
  • sedafamen
  • phendimetrazine tartrate
  • phendimetrazine HCl
minor descriptor (66-86); file maintained to MORPHOLINES (66-86); on-line & INDEX MEDICUS search MORPHOLINES (66-86); RN given refers to parent cpd without isomeric designation
  • Molecular weight: 191.27
  • Formula: C12H17NO
  • CLOGP: 1.92
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -1.90
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 0 Hosey CM, Chan R, Benet LZ
S (Water solubility) 17 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
July 28, 1976 FDA TG UNITED LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sudden cardiac death 96.71 67.07 13 77 2127 63486805

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sudden cardiac death 100.99 66.51 15 93 5210 79739070

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA PE N0000175372 Appetite Suppression
FDA EPC N0000175423 Sympathomimetic Amine Anorectic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D000697 Central Nervous System Stimulants
FDA PE N0000175651 Increased Sympathetic Activity

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Obesity indication 414916001 DOID:9970
Heart valve disorder contraindication 368009 DOID:4079
Glaucoma contraindication 23986001 DOID:1686
Feeling agitated contraindication 24199005
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Mild pre-eclampsia contraindication 41114007
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Substance abuse contraindication 66214007
Psychotic disorder contraindication 69322001
Pulmonary hypertension contraindication 70995007 DOID:6432
Arteriosclerotic vascular disease contraindication 72092001
Angina pectoris contraindication 194828000
Syncope contraindication 271594007
Hypertensive urgency contraindication 443482000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.77 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter INHIBITOR CHEMBL CHEMBL
Sodium-dependent dopamine transporter Transporter INHIBITOR CHEMBL CHEMBL
5-hydroxytryptamine receptor 1A GPCR Kd 4.90 CHEMBL

External reference:

IDSource
4018492 VUID
N0000146814 NUI
D02080 KEGG_DRUG
7635-51-0 SECONDARY_CAS_RN
50-58-8 SECONDARY_CAS_RN
4018491 VANDF
4018492 VANDF
4019885 VANDF
C0070549 UMLSCUI
CHEBI:8059 CHEBI
CHEMBL1615439 ChEMBL_ID
CHEMBL1744 ChEMBL_ID
DB01579 DRUGBANK_ID
CHEMBL2062163 ChEMBL_ID
CHEMBL1898523 ChEMBL_ID
30487 PUBCHEM_CID
982 INN_ID
C100294 MESH_SUPPLEMENTAL_RECORD_UI
AB2794W8KV UNII
297716 RXNORM
2337 MMSL
5268 MMSL
d00809 MMSL
001869 NDDF
001870 NDDF
001871 NDDF
26945002 SNOMEDCT_US
373340007 SNOMEDCT_US
39142008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0185-4057 TABLET 35 mg ORAL ANDA 16 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0185-5254 CAPSULE, EXTENDED RELEASE 105 mg ORAL NDA 23 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-041 TABLET 35 mg ORAL ANDA 12 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10702-045 TABLET 35 mg ORAL ANDA 13 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10702-077 TABLET 35 mg ORAL ANDA 13 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10702-078 TABLET 35 mg ORAL ANDA 13 sections
phendimetrazine tartrate HUMAN PRESCRIPTION DRUG LABEL 1 12634-028 TABLET 35 mg ORAL ANDA 21 sections
phendimetrazine tartrate HUMAN PRESCRIPTION DRUG LABEL 1 12634-539 TABLET 35 mg ORAL ANDA 22 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 12634-910 CAPSULE, EXTENDED RELEASE 105 mg ORAL NDA 23 sections
PHENDIMETRAZINE TARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 16590-642 TABLET 35 mg ORAL ANDA 11 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 17224-500 TABLET 35 mg ORAL ANDA 13 sections
PHENDIMETRAZINE TARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 17224-501 TABLET 35 mg ORAL ANDA 16 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 17224-800 TABLET 35 mg ORAL ANDA 13 sections
PHENDIMETRAZINE TARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 17224-831 CAPSULE, EXTENDED RELEASE 105 mg ORAL NDA 23 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 21695-597 TABLET 35 mg ORAL ANDA 10 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 33261-341 TABLET 35 mg ORAL ANDA 12 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 33261-390 CAPSULE, EXTENDED RELEASE 105 mg ORAL NDA 23 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 43063-510 TABLET 35 mg ORAL ANDA 13 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 43063-510 TABLET 35 mg ORAL ANDA 13 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 43063-510 TABLET 35 mg ORAL ANDA 13 sections
PHENDIMETRAZINE TARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 43063-892 CAPSULE, EXTENDED RELEASE 105 mg ORAL NDA 23 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0385 TABLET 35 mg ORAL ANDA 13 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0715 TABLET 35 mg ORAL ANDA 13 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0715 TABLET 35 mg ORAL ANDA 13 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0715 TABLET 35 mg ORAL ANDA 13 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2235 TABLET 35 mg ORAL ANDA 13 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2235 TABLET 35 mg ORAL ANDA 13 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2592 TABLET 35 mg ORAL ANDA 16 sections
Phendimetrazine Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3976 TABLET 35 mg ORAL ANDA 13 sections
PHENDIMETRAZINE TARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-3988 CAPSULE, EXTENDED RELEASE 105 mg ORAL NDA 23 sections