phencyclidine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
muscarinic receptors agonists/antagonists 2121 77-10-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phencyclidine hydrochloride
  • phencyclidine
  • phencyclidine HCl
  • phencyclidine hydrobromide
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
  • Molecular weight: 243.39
  • Formula: C17H25N
  • CLOGP: 5.10
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -4.87
  • ROTB: 2

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 405.38 236.90 82 189 27865 4610856
Toxicity to various agents 364.72 236.90 89 182 71951 4566770
Completed suicide 271.34 236.90 64 207 42381 4596340

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35471 psychotropic drug
CHEBI has role CHEBI:38867 anaesthetic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018691 Excitatory Amino Acid Antagonists
MeSH PA D006213 Hallucinogens
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.1 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lysosomal Pro-X carboxypeptidase Enzyme IC50 7.04 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.96 CHEMBL
Glutamate NMDA receptor; GRIN1/GRIN2B Ion channel IC50 5.90 CHEMBL
Glutamate NMDA receptor; GRIN1/GRIN2A Ion channel IC50 6.40 CHEMBL
Glutamate [NMDA] receptor Ion channel Ki 7.82 CHEMBL
Glutamate receptor ionotropic, NMDA 1 Ion channel Ki 7.28 CHEMBL
Muscarinic acetylcholine receptor GPCR Kd 5.04 CHEMBL
Glutamate receptor ionotropic, NMDA 2C Ion channel Ki 7.22 CHEMBL
Cholinesterase Enzyme Ki 6.28 CHEMBL
Glutamate NMDA receptor Ion channel Ki 7.42 CHEMBL
Acetylcholine receptor subunit alpha Ion channel IC50 6.66 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 6.28 CHEMBL

External reference:

IDSource
D05453 KEGG_DRUG
9721008 SNOMEDCT_US
d03880 MMSL
4027426 VANDF
6468 PUBCHEM_CID
CHEBI:8058 CHEBI
CHEMBL275528 ChEMBL_ID
CHEMBL542581 ChEMBL_ID
J1DOI7UV76 UNII
1058 INN_ID
956-90-1 SECONDARY_CAS_RN
1PC PDB_CHEM_ID
DB03575 DRUGBANK_ID
D010622 MESH_DESCRIPTOR_UI
4282 IUPHAR_LIGAND_ID

Pharmaceutical products:

None