ancitabine indications/contra

Stem definitionDrug idCAS RN
nucleosides antiviral or antineoplastic agents, cytarabine or azacitidine derivatives 212 31698-14-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ancitabine
  • ancytabine
  • cyclocytidine
Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.
  • Molecular weight: 225.20
  • Formula: C9H11N3O4
  • CLOGP: -2.75
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 98.37
  • ALOGS: -1.85
  • ROTB: 1

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:35610 antineoplastic agent
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D009676 Noxae

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.69 acidic
pKa2 9.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
25051 PUBCHEM_CID
N0000170630 NDFRT
CHEBI:74838 CHEBI
CHEMBL1412614 ChEMBL_ID
D003504 MESH_DESCRIPTOR_UI
DO2D32W0VC UNII
3992 INN_ID

Pharmaceutical products:

None