phenacemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2114 | 63-98-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Phenacemide (Phenurone) is an older antiepileptic agent. It is capable of relieving patients resistant to other antiepileptics, although its therapeutic effectiveness must be balanced against its toxic effects.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.50 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 280.60 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 28, 1951 | FDA | ABBVIE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N03AX07 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Other antiepileptics |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Epilepsy | indication | 84757009 | DOID:1826 |
| Epilepsy characterized by intractable complex partial seizures | indication | 442481002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.1 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel protein type 1 subunit alpha | Ion channel | BLOCKER | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4018717 | VUID |
| N0000147023 | NUI |
| D00504 | KEGG_DRUG |
| 4018717 | VANDF |
| C0070525 | UMLSCUI |
| CHEBI:8049 | CHEBI |
| CHEMBL918 | ChEMBL_ID |
| DB01121 | DRUGBANK_ID |
| 4753 | PUBCHEM_CID |
| 92 | INN_ID |
| C005396 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7265 | IUPHAR_LIGAND_ID |
| PAI7J52V09 | UNII |
| 204310 | RXNORM |
| 1302 | MMSL |
| 5265 | MMSL |
| d00947 | MMSL |
| 001632 | NDDF |
| 18712002 | SNOMEDCT_US |
| 400358006 | SNOMEDCT_US |
Pharmaceutical products:
None