perlapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 2111 1977-11-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • perlapine
  • hypnodin
  • perlapine monohydrochloride
  • perlapine hydrochloride
  • perlapine HCl
  • HUF-2333
  • Molecular weight: 291.40
  • Formula: C19H21N3
  • CLOGP: 3.24
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 18.84
  • ALOGS: -3.44
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 5.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 7.22 PDSP
5-hydroxytryptamine receptor 2A GPCR Ki 7.70 PDSP
5-hydroxytryptamine receptor 6 GPCR Ki 6.82 PDSP
D(3) dopamine receptor GPCR Ki 7 PDSP
Histamine H4 receptor GPCR Ki 5.32 CHEMBL
D(4) dopamine receptor GPCR Ki 7.52 PDSP
D(2) dopamine receptor GPCR IC50 5.57 CHEMBL

External reference:

IDSource
D01438 KEGG_DRUG
C0070450 UMLSCUI
CHEBI:31983 CHEBI
CHEMBL340801 ChEMBL_ID
C003910 MESH_SUPPLEMENTAL_RECORD_UI
16106 PUBCHEM_CID
2825 INN_ID
4N8UJJ27IM UNII

Pharmaceutical products:

None