periciazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2107 | 2622-26-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 50 | mg | O |
| 20 | mg | P |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Resting tremor | 61.62 | 52.60 | 9 | 267 | 814 | 63487932 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Resting tremor | 53.80 | 46.31 | 9 | 436 | 1512 | 79742431 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05AC01 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with piperidine structure |
| CHEBI has role | CHEBI:35717 | hypnotics |
| CHEBI has role | CHEBI:37887 | adrenergic blockers |
| CHEBI has role | CHEBI:65190 | typical antipsychotic drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.84 | Basic |
| pKa2 | 2.39 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(1A) dopamine receptor | GPCR | ANTAGONIST | Ki | 8 | IUPHAR | ||||
| Androgen receptor | Transcription factor | Ki | 5.52 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 5.15 | CHEMBL | |||||
| Cholinesterase | Enzyme | IC50 | 6.64 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01485 | KEGG_DRUG |
| C0033459 | UMLSCUI |
| CHEBI:31981 | CHEBI |
| CHEMBL251940 | ChEMBL_ID |
| DB01608 | DRUGBANK_ID |
| C084584 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4747 | PUBCHEM_CID |
| 9216 | IUPHAR_LIGAND_ID |
| 1398 | INN_ID |
| 3405M6FD73 | UNII |
| 8766 | RXNORM |
| 003467 | NDDF |
| 321467007 | SNOMEDCT_US |
| 395825007 | SNOMEDCT_US |
Pharmaceutical products:
None