pentaerithrityl tetranitrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
NO2 - derivatives 2087 78-11-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tetranitropentaerythrite
  • tetranitropentaerythritol
  • nitropentaerythrite
  • nitropentaerythritol
  • pentaerithrityl tetranitrate
  • pentanitrine
  • pentaerythritol tetranitrate
A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025)
  • Molecular weight: 316.14
  • Formula: C5H8N4O12
  • CLOGP: 1.21
  • LIPINSKI: 1
  • HAC: 16
  • HDO: 0
  • TPSA: 220.20
  • ALOGS: -3.38
  • ROTB: 12

Drug dosage:

DoseUnitRoute
0.12 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01DA05 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Organic nitrates
ATC C01DA55 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Organic nitrates
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:63490 explosive compounds

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018459 VUID
N0000146783 NUI
D01721 KEGG_DRUG
4018459 VANDF
CHEBI:25879 CHEBI
CHEMBL466659 ChEMBL_ID
DB06154 DRUGBANK_ID
7992 RXNORM
000686 NDDF
10422008 SNOMEDCT_US
386836006 SNOMEDCT_US
C0030858 UMLSCUI
D010417 MESH_DESCRIPTOR_UI
6518 PUBCHEM_CID
1455 INN_ID
10L39TRG1Z UNII

Pharmaceutical products:

None