phenoxymethylpenicillin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, 6-aminopenicillanic acid derivatives | 2083 | 87-08-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 2 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.45 mg/mL | Bocci G, Oprea TI, Benet LZ |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 71.35 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 0.41 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 6.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.45 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.84 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 13, 1958 | FDA | WYETH AYERST |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 349.22 | 17.50 | 280 | 6656 | 310407 | 63171679 |
| Rash | 125.65 | 17.50 | 221 | 6715 | 560650 | 62921436 |
| Myocardial depression | 121.95 | 17.50 | 24 | 6912 | 480 | 63481606 |
| Lip swelling | 118.86 | 17.50 | 61 | 6875 | 31002 | 63451084 |
| Decorticate posture | 114.30 | 17.50 | 21 | 6915 | 286 | 63481800 |
| Swelling face | 68.08 | 17.50 | 56 | 6880 | 63419 | 63418667 |
| Lipase increased | 64.24 | 17.50 | 28 | 6908 | 9872 | 63472214 |
| Ventricular hypokinesia | 57.72 | 17.50 | 21 | 6915 | 4623 | 63477463 |
| Urticaria | 48.49 | 17.50 | 74 | 6862 | 165728 | 63316358 |
| Eosinophilia | 47.26 | 17.50 | 30 | 6906 | 22726 | 63459360 |
| Hypothermia | 47.13 | 17.50 | 25 | 6911 | 13556 | 63468530 |
| Oral discomfort | 46.93 | 17.50 | 22 | 6914 | 9179 | 63472907 |
| Gastric cancer | 46.48 | 17.50 | 18 | 6918 | 4705 | 63477381 |
| Lichen nitidus | 45.28 | 17.50 | 8 | 6928 | 86 | 63482000 |
| Rash macular | 44.08 | 17.50 | 29 | 6907 | 23335 | 63458751 |
| Hypersensitivity | 44.05 | 17.50 | 98 | 6838 | 292587 | 63189499 |
| Toxic epidermal necrolysis | 41.95 | 17.50 | 29 | 6907 | 25305 | 63456781 |
| Coma scale abnormal | 41.52 | 17.50 | 17 | 6919 | 5136 | 63476950 |
| Drug reaction with eosinophilia and systemic symptoms | 40.82 | 17.50 | 32 | 6904 | 33804 | 63448282 |
| Swollen tongue | 37.91 | 17.50 | 31 | 6905 | 34769 | 63447317 |
| Respiratory depression | 30.78 | 17.50 | 19 | 6917 | 13696 | 63468390 |
| Pancreatitis | 30.59 | 17.50 | 32 | 6904 | 49023 | 63433063 |
| Agranulocytosis | 28.66 | 17.50 | 23 | 6913 | 25111 | 63456975 |
| Acute respiratory distress syndrome | 27.83 | 17.50 | 22 | 6914 | 23512 | 63458574 |
| Encephalopathy | 27.37 | 17.50 | 27 | 6909 | 38593 | 63443493 |
| Hepatocellular injury | 26.94 | 17.50 | 23 | 6913 | 27358 | 63454728 |
| Intentional overdose | 25.85 | 17.50 | 36 | 6900 | 74116 | 63407970 |
| Unresponsive to stimuli | 24.63 | 17.50 | 24 | 6912 | 33792 | 63448294 |
| Hepatobiliary infection | 24.30 | 17.50 | 4 | 6932 | 27 | 63482059 |
| Cross sensitivity reaction | 24.01 | 17.50 | 9 | 6927 | 2153 | 63479933 |
| Adenovirus reactivation | 23.59 | 17.50 | 5 | 6931 | 146 | 63481940 |
| Granulomatous dermatitis | 23.27 | 17.50 | 5 | 6931 | 156 | 63481930 |
| Mouth swelling | 23.14 | 17.50 | 11 | 6925 | 4729 | 63477357 |
| Pruritus | 22.99 | 17.50 | 89 | 6847 | 361364 | 63120722 |
| Oligohydramnios | 22.88 | 17.50 | 12 | 6924 | 6354 | 63475732 |
| Lichenification | 22.80 | 17.50 | 6 | 6930 | 450 | 63481636 |
| Subacute combined cord degeneration | 21.49 | 17.50 | 5 | 6931 | 225 | 63481861 |
| Obstructive airways disorder | 19.57 | 17.50 | 17 | 6919 | 20682 | 63461404 |
| Intravascular haemolysis | 19.39 | 17.50 | 5 | 6931 | 346 | 63481740 |
| Eye swelling | 19.37 | 17.50 | 18 | 6918 | 23900 | 63458186 |
| Joint swelling | 19.14 | 17.50 | 6 | 6930 | 327660 | 63154426 |
| Drug ineffective | 18.51 | 17.50 | 56 | 6880 | 1044709 | 62437377 |
| Cytomegalovirus viraemia | 18.48 | 17.50 | 10 | 6926 | 5639 | 63476447 |
| Left ventricular dysfunction | 18.16 | 17.50 | 13 | 6923 | 11975 | 63470111 |
| Graft versus host disease in skin | 18.14 | 17.50 | 8 | 6928 | 2897 | 63479189 |
| Rheumatoid arthritis | 18.10 | 17.50 | 3 | 6933 | 253816 | 63228270 |
| Pulmonary function test abnormal | 18.09 | 17.50 | 7 | 6929 | 1823 | 63480263 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Spinal muscular atrophy | 113.03 | 18.49 | 24 | 7034 | 372 | 34949501 |
| Pneumococcal sepsis | 97.25 | 18.49 | 26 | 7032 | 1111 | 34948762 |
| Acute generalised exanthematous pustulosis | 89.78 | 18.49 | 38 | 7020 | 6738 | 34943135 |
| Drug hypersensitivity | 89.40 | 18.49 | 95 | 6963 | 80434 | 34869439 |
| Disease complication | 82.52 | 18.49 | 28 | 7030 | 2708 | 34947165 |
| Increased bronchial secretion | 80.10 | 18.49 | 25 | 7033 | 1856 | 34948017 |
| Motor neurone disease | 80.01 | 18.49 | 19 | 7039 | 498 | 34949375 |
| Sputum increased | 78.40 | 18.49 | 26 | 7032 | 2344 | 34947529 |
| Stoma closure | 74.46 | 18.49 | 16 | 7042 | 263 | 34949610 |
| Respiratory tract infection bacterial | 73.02 | 18.49 | 23 | 7035 | 1759 | 34948114 |
| Nocardiosis | 72.48 | 18.49 | 28 | 7030 | 3923 | 34945950 |
| Ischaemic cerebral infarction | 72.18 | 18.49 | 21 | 7037 | 1226 | 34948647 |
| Lower respiratory tract infection bacterial | 70.24 | 18.49 | 17 | 7041 | 484 | 34949389 |
| Chest X-ray abnormal | 66.13 | 18.49 | 27 | 7031 | 4371 | 34945502 |
| Bronchial disorder | 65.45 | 18.49 | 20 | 7038 | 1383 | 34948490 |
| Lymphadenectomy | 63.95 | 18.49 | 15 | 7043 | 372 | 34949501 |
| Rash | 63.45 | 18.49 | 139 | 6919 | 222613 | 34727260 |
| Resuscitation | 60.56 | 18.49 | 19 | 7039 | 1434 | 34948439 |
| Metabolic disorder | 60.01 | 18.49 | 25 | 7033 | 4258 | 34945615 |
| Brief psychotic disorder with marked stressors | 54.66 | 18.49 | 12 | 7046 | 219 | 34949654 |
| Lung consolidation | 52.18 | 18.49 | 25 | 7033 | 5911 | 34943962 |
| Scoliosis | 51.96 | 18.49 | 20 | 7038 | 2773 | 34947100 |
| Cerebral ischaemia | 50.69 | 18.49 | 25 | 7033 | 6297 | 34943576 |
| Brain injury | 48.39 | 18.49 | 24 | 7034 | 6118 | 34943755 |
| Motor dysfunction | 48.36 | 18.49 | 25 | 7033 | 6949 | 34942924 |
| Demyelination | 45.79 | 18.49 | 19 | 7039 | 3202 | 34946671 |
| Swelling face | 44.36 | 18.49 | 37 | 7021 | 23068 | 34926805 |
| Pyrexia | 43.96 | 18.49 | 157 | 6901 | 332856 | 34617017 |
| Intestinal ischaemia | 43.00 | 18.49 | 24 | 7034 | 7770 | 34942103 |
| Morganella infection | 40.24 | 18.49 | 11 | 7047 | 511 | 34949362 |
| Drug reaction with eosinophilia and systemic symptoms | 40.23 | 18.49 | 41 | 7017 | 32971 | 34916902 |
| Inflammation | 39.79 | 18.49 | 38 | 7020 | 28257 | 34921616 |
| Pleocytosis | 39.63 | 18.49 | 11 | 7047 | 541 | 34949332 |
| Staphylococcal mediastinitis | 37.89 | 18.49 | 7 | 7051 | 50 | 34949823 |
| Bronchial haemorrhage | 36.91 | 18.49 | 11 | 7047 | 698 | 34949175 |
| Atelectasis | 35.30 | 18.49 | 29 | 7029 | 17698 | 34932175 |
| Muscle atrophy | 33.39 | 18.49 | 20 | 7038 | 7384 | 34942489 |
| Graft versus host disease | 31.49 | 18.49 | 22 | 7036 | 10547 | 34939326 |
| Secretion discharge | 29.39 | 18.49 | 17 | 7041 | 5888 | 34943985 |
| Thrombotic microangiopathy | 29.07 | 18.49 | 21 | 7037 | 10609 | 34939264 |
| Plasma cell myeloma | 29.03 | 18.49 | 39 | 7019 | 41998 | 34907875 |
| Prothrombin level abnormal | 28.69 | 18.49 | 6 | 7052 | 86 | 34949787 |
| Injury | 27.60 | 18.49 | 27 | 7031 | 20660 | 34929213 |
| Circulatory collapse | 27.22 | 18.49 | 27 | 7031 | 21011 | 34928862 |
| Toxoplasmosis | 26.55 | 18.49 | 10 | 7048 | 1306 | 34948567 |
| Tachypnoea | 26.47 | 18.49 | 25 | 7033 | 18327 | 34931546 |
| Death | 26.39 | 18.49 | 25 | 7033 | 398024 | 34551849 |
| Mechanical ventilation | 25.92 | 18.49 | 11 | 7047 | 1959 | 34947914 |
| Disseminated varicella zoster virus infection | 25.84 | 18.49 | 7 | 7051 | 314 | 34949559 |
| Lung infiltration | 25.45 | 18.49 | 21 | 7037 | 12884 | 34936989 |
| Axonal neuropathy | 24.73 | 18.49 | 9 | 7049 | 1068 | 34948805 |
| Endotracheal intubation | 24.21 | 18.49 | 12 | 7046 | 3053 | 34946820 |
| Brain abscess | 23.99 | 18.49 | 12 | 7046 | 3113 | 34946760 |
| Sinusitis bacterial | 23.18 | 18.49 | 7 | 7051 | 465 | 34949408 |
| Cytomegalovirus oesophagitis | 22.70 | 18.49 | 7 | 7051 | 499 | 34949374 |
| Antipsychotic drug level decreased | 21.51 | 18.49 | 8 | 7050 | 1009 | 34948864 |
| Osteomyelitis chronic | 21.42 | 18.49 | 6 | 7052 | 305 | 34949568 |
| Conjunctivitis bacterial | 21.39 | 18.49 | 5 | 7053 | 122 | 34949751 |
| Acute lymphocytic leukaemia recurrent | 21.35 | 18.49 | 11 | 7047 | 3033 | 34946840 |
| Respiratory arrest | 20.87 | 18.49 | 27 | 7031 | 28016 | 34921857 |
| Rash papular | 20.85 | 18.49 | 17 | 7041 | 10261 | 34939612 |
| Parvovirus B19 infection | 19.09 | 18.49 | 7 | 7051 | 848 | 34949025 |
| Pharyngeal oedema | 18.98 | 18.49 | 13 | 7045 | 6034 | 34943839 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Rash | 158.07 | 14.99 | 306 | 12235 | 578052 | 79153795 |
| Drug hypersensitivity | 130.31 | 14.99 | 195 | 12346 | 298721 | 79433126 |
| Lip swelling | 120.77 | 14.99 | 77 | 12464 | 40834 | 79691013 |
| Spinal muscular atrophy | 112.65 | 14.99 | 23 | 12518 | 380 | 79731467 |
| Myocardial depression | 112.06 | 14.99 | 24 | 12517 | 505 | 79731342 |
| Swelling face | 106.92 | 14.99 | 89 | 12452 | 71123 | 79660724 |
| Decorticate posture | 104.38 | 14.99 | 21 | 12520 | 321 | 79731526 |
| Pneumococcal sepsis | 93.89 | 14.99 | 26 | 12515 | 1636 | 79730211 |
| Motor neurone disease | 81.66 | 14.99 | 19 | 12522 | 589 | 79731258 |
| Stoma closure | 76.81 | 14.99 | 16 | 12525 | 293 | 79731554 |
| Drug reaction with eosinophilia and systemic symptoms | 71.89 | 14.99 | 68 | 12473 | 64176 | 79667671 |
| Respiratory tract infection bacterial | 70.96 | 14.99 | 22 | 12519 | 2055 | 79729792 |
| Nocardiosis | 69.39 | 14.99 | 28 | 12513 | 5651 | 79726196 |
| Increased bronchial secretion | 68.37 | 14.99 | 24 | 12517 | 3303 | 79728544 |
| Lower respiratory tract infection bacterial | 63.54 | 14.99 | 17 | 12524 | 939 | 79730908 |
| Bronchial disorder | 63.04 | 14.99 | 21 | 12520 | 2468 | 79729379 |
| Disease complication | 62.60 | 14.99 | 25 | 12516 | 4912 | 79726935 |
| Acute generalised exanthematous pustulosis | 62.43 | 14.99 | 37 | 12504 | 17217 | 79714630 |
| Sputum increased | 60.72 | 14.99 | 24 | 12517 | 4589 | 79727258 |
| Ischaemic cerebral infarction | 58.72 | 14.99 | 20 | 12521 | 2515 | 79729332 |
| Chest X-ray abnormal | 54.39 | 14.99 | 26 | 12515 | 7857 | 79723990 |
| Brief psychotic disorder with marked stressors | 54.16 | 14.99 | 12 | 12529 | 297 | 79731550 |
| Resuscitation | 51.93 | 14.99 | 18 | 12523 | 2386 | 79729461 |
| Brain injury | 50.51 | 14.99 | 28 | 12513 | 11489 | 79720358 |
| Lymphadenectomy | 50.12 | 14.99 | 15 | 12526 | 1244 | 79730603 |
| Eosinophilia | 46.94 | 14.99 | 46 | 12495 | 45299 | 79686548 |
| Lung consolidation | 45.51 | 14.99 | 24 | 12517 | 8923 | 79722924 |
| Rash macular | 45.17 | 14.99 | 37 | 12504 | 28862 | 79702985 |
| Metabolic disorder | 44.95 | 14.99 | 24 | 12517 | 9146 | 79722701 |
| Morganella infection | 43.02 | 14.99 | 13 | 12528 | 1114 | 79730733 |
| Lichen nitidus | 42.12 | 14.99 | 8 | 12533 | 89 | 79731758 |
| Swollen tongue | 41.87 | 14.99 | 42 | 12499 | 42528 | 79689319 |
| Scoliosis | 40.76 | 14.99 | 21 | 12520 | 7443 | 79724404 |
| Thrombotic microangiopathy | 40.61 | 14.99 | 30 | 12511 | 20139 | 79711708 |
| Cerebral ischaemia | 40.48 | 14.99 | 24 | 12517 | 11171 | 79720676 |
| Granulomatous dermatitis | 40.25 | 14.99 | 10 | 12531 | 411 | 79731436 |
| Staphylococcal mediastinitis | 39.51 | 14.99 | 7 | 12534 | 51 | 79731796 |
| Ventricular hypokinesia | 36.47 | 14.99 | 21 | 12520 | 9258 | 79722589 |
| Toxic skin eruption | 35.80 | 14.99 | 29 | 12512 | 22264 | 79709583 |
| Drug ineffective | 35.66 | 14.99 | 73 | 12468 | 1080840 | 78651007 |
| Oral discomfort | 35.49 | 14.99 | 21 | 12520 | 9739 | 79722108 |
| Pyrexia | 35.26 | 14.99 | 204 | 12337 | 678505 | 79053342 |
| Encephalopathy | 35.16 | 14.99 | 48 | 12493 | 67349 | 79664498 |
| Motor dysfunction | 34.44 | 14.99 | 24 | 12517 | 14709 | 79717138 |
| Intestinal ischaemia | 34.30 | 14.99 | 23 | 12518 | 13247 | 79718600 |
| Demyelination | 33.80 | 14.99 | 19 | 12522 | 8004 | 79723843 |
| Pleocytosis | 31.95 | 14.99 | 11 | 12530 | 1428 | 79730419 |
| Muscle atrophy | 30.32 | 14.99 | 20 | 12521 | 11212 | 79720635 |
| Rash papular | 30.01 | 14.99 | 26 | 12515 | 21890 | 79709957 |
| Coma scale abnormal | 29.81 | 14.99 | 18 | 12523 | 8660 | 79723187 |
| Eye swelling | 29.56 | 14.99 | 28 | 12513 | 26440 | 79705407 |
| Graft versus host disease | 29.46 | 14.99 | 22 | 12519 | 15004 | 79716843 |
| Bronchial haemorrhage | 28.96 | 14.99 | 10 | 12531 | 1310 | 79730537 |
| Hepatobiliary infection | 28.65 | 14.99 | 5 | 12536 | 33 | 79731814 |
| Toxic epidermal necrolysis | 28.32 | 14.99 | 35 | 12506 | 44546 | 79687301 |
| Cross sensitivity reaction | 27.93 | 14.99 | 13 | 12528 | 3699 | 79728148 |
| Brain abscess | 27.28 | 14.99 | 14 | 12527 | 4922 | 79726925 |
| Hypothermia | 27.20 | 14.99 | 25 | 12516 | 22721 | 79709126 |
| Mechanical ventilation | 24.98 | 14.99 | 11 | 12530 | 2753 | 79729094 |
| Hypersensitivity | 24.80 | 14.99 | 94 | 12447 | 262145 | 79469702 |
| Mouth swelling | 24.60 | 14.99 | 14 | 12527 | 6037 | 79725810 |
| Pharyngeal oedema | 23.69 | 14.99 | 20 | 12521 | 16252 | 79715595 |
| Bone marrow transplant rejection | 23.55 | 14.99 | 6 | 12535 | 273 | 79731574 |
| Rash maculo-papular | 23.49 | 14.99 | 36 | 12505 | 56042 | 79675805 |
| Plasma cell myeloma | 23.45 | 14.99 | 35 | 12506 | 53224 | 79678623 |
| Death | 23.44 | 14.99 | 33 | 12508 | 566481 | 79165366 |
| Haemolysis | 23.44 | 14.99 | 18 | 12523 | 12794 | 79719053 |
| Malaise | 23.29 | 14.99 | 144 | 12397 | 489725 | 79242122 |
| Atelectasis | 23.23 | 14.99 | 27 | 12514 | 32230 | 79699617 |
| Disseminated varicella zoster virus infection | 22.87 | 14.99 | 7 | 12534 | 626 | 79731221 |
| Tonsil cancer | 22.38 | 14.99 | 8 | 12533 | 1160 | 79730687 |
| Endotracheal intubation | 22.20 | 14.99 | 12 | 12529 | 4685 | 79727162 |
| Toxoplasmosis | 22.03 | 14.99 | 10 | 12531 | 2687 | 79729160 |
| Antipsychotic drug level decreased | 22.01 | 14.99 | 8 | 12533 | 1216 | 79730631 |
| Hepatocellular injury | 22.00 | 14.99 | 32 | 12509 | 47561 | 79684286 |
| Cytomegalovirus oesophagitis | 21.61 | 14.99 | 7 | 12534 | 753 | 79731094 |
| Axonal neuropathy | 21.27 | 14.99 | 9 | 12532 | 2045 | 79729802 |
| Secretion discharge | 20.92 | 14.99 | 18 | 12523 | 15004 | 79716843 |
| Fall | 20.57 | 14.99 | 28 | 12513 | 487601 | 79244246 |
| Parvovirus B19 infection | 20.53 | 14.99 | 8 | 12533 | 1472 | 79730375 |
| Obstructive airways disorder | 20.46 | 14.99 | 25 | 12516 | 31434 | 79700413 |
| Agranulocytosis | 20.41 | 14.99 | 30 | 12511 | 45000 | 79686847 |
| Herpes simplex reactivation | 20.34 | 14.99 | 6 | 12535 | 473 | 79731374 |
| Gastric cancer | 20.17 | 14.99 | 15 | 12526 | 10164 | 79721683 |
| Urticaria | 19.70 | 14.99 | 69 | 12472 | 185132 | 79546715 |
| Lung infiltration | 19.63 | 14.99 | 21 | 12520 | 22891 | 79708956 |
| Graft versus host disease in skin | 19.33 | 14.99 | 12 | 12529 | 6061 | 79725786 |
| Tachypnoea | 18.50 | 14.99 | 24 | 12517 | 32039 | 79699808 |
| Cholestasis | 18.46 | 14.99 | 31 | 12510 | 52078 | 79679769 |
| Circulatory collapse | 18.40 | 14.99 | 26 | 12515 | 37642 | 79694205 |
| Unresponsive to stimuli | 18.20 | 14.99 | 32 | 12509 | 55756 | 79676091 |
| Osteomyelitis chronic | 18.07 | 14.99 | 6 | 12535 | 698 | 79731149 |
| Cryptosporidiosis infection | 17.75 | 14.99 | 6 | 12535 | 737 | 79731110 |
| Subacute combined cord degeneration | 17.73 | 14.99 | 5 | 12536 | 336 | 79731511 |
| Pulmonary vasculitis | 17.61 | 14.99 | 6 | 12535 | 755 | 79731092 |
| Joint swelling | 17.47 | 14.99 | 12 | 12529 | 288634 | 79443213 |
| Adenovirus reactivation | 17.08 | 14.99 | 5 | 12536 | 384 | 79731463 |
| Septic shock | 16.91 | 14.99 | 50 | 12491 | 122751 | 79609096 |
| Respiratory syncytial virus infection | 16.74 | 14.99 | 13 | 12528 | 9389 | 79722458 |
| Acute lymphocytic leukaemia recurrent | 16.74 | 14.99 | 10 | 12531 | 4714 | 79727133 |
| Pharyngeal swelling | 16.71 | 14.99 | 12 | 12529 | 7707 | 79724140 |
| Conjunctivitis bacterial | 16.37 | 14.99 | 5 | 12536 | 444 | 79731403 |
| Injury | 16.30 | 14.99 | 37 | 12504 | 77459 | 79654388 |
| Acanthamoeba infection | 15.79 | 14.99 | 5 | 12536 | 500 | 79731347 |
| Sinusitis bacterial | 15.79 | 14.99 | 7 | 12534 | 1780 | 79730067 |
| Conversion disorder | 15.52 | 14.99 | 7 | 12534 | 1854 | 79729993 |
| Hepatic enzyme increased | 15 | 14.99 | 5 | 12536 | 182605 | 79549242 |
FDA Adverse Event Reporting System (Pediatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Plagiocephaly | 23.20 | 10.71 | 4 | 4 | 64 | 89720 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01CE02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Beta-lactamase sensitive penicillins |
| FDA CS | M0016152 | Penicillins |
| FDA EPC | N0000175497 | Penicillin-class Antibacterial |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Acute otitis media | indication | 3110003 | |
| Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
| Gingivostomatitis | indication | 20607006 | |
| Scarlet fever | indication | 30242009 | DOID:8596 |
| Streptococcal tonsillitis | indication | 41582007 | |
| Erysipelas | indication | 44653001 | DOID:11330 |
| Upper respiratory infection | indication | 54150009 | |
| Streptococcus pyogenes infection | indication | 302809008 | |
| Infective otitis media | indication | 312218008 | |
| Fusospirochetal pharyngitis | indication | 399095008 | |
| Pharyngitis | indication | 405737000 | DOID:2275 |
| Infection due to Staphylococcus aureus | indication | 406602003 | |
| Pneumococcal Acute Otitis Media | indication | ||
| Upper Respiratory Pneumococcal Infection | indication | ||
| Infection Prevention from Tooth Extraction | indication | ||
| Rheumatic Fever Prevention | indication | ||
| Upper Respiratory Streptococcal Infection | indication | ||
| Actinomycotic infection | off-label use | 11817007 | DOID:8478 |
| Lyme disease | off-label use | 23502006 | DOID:11729 |
| Infection due to anaerobic bacteria | off-label use | 423451008 | |
| Pneumococcal Infection Prevention in Sickle Cell Disease | off-label use | ||
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Infectious mononucleosis | contraindication | 271558008 | DOID:8568 |
| Pseudomembranous enterocolitis | contraindication | 397683000 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Respiratory infections caused by pathogens | Indication |
| Cats | Urogenital infections caused by pathogens | Indication |
| Cats | Skin and soft tissue infections caused by pathogens | Indication |
| Cats | Septicemia caused by pathogens | Indication |
| Dogs | Treatment of respiratory, urogenital, skin, and soft tissue infections and septicemia caused by pathogens | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Penicillin VK Filmtab 250 mg | Boehringer lngelheim Animal Health USA Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.79 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| N0000011298 | NUI |
| D05411 | KEGG_DRUG |
| 132-98-9 | SECONDARY_CAS_RN |
| 4017436 | VANDF |
| C0030840 | UMLSCUI |
| CHEBI:27446 | CHEBI |
| PNV | PDB_CHEM_ID |
| CHEMBL615 | ChEMBL_ID |
| CHEMBL1200852 | ChEMBL_ID |
| DB00417 | DRUGBANK_ID |
| 10920 | IUPHAR_LIGAND_ID |
| 6869 | PUBCHEM_CID |
| 203195 | RXNORM |
| 179406 | MMSL |
| 2179 | MMSL |
| 5248 | MMSL |
| d07730 | MMSL |
| 002684 | NDDF |
| 002686 | NDDF |
| 372725003 | SNOMEDCT_US |
| 39359008 | SNOMEDCT_US |
| 56723006 | SNOMEDCT_US |
| D010404 | MESH_DESCRIPTOR_UI |
| 518 | INN_ID |
| Z61I075U2W | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-1172 | TABLET | 250 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-1172 | TABLET | 250 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-1172 | TABLET | 250 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-1174 | TABLET | 500 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-1174 | TABLET | 500 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-1174 | TABLET | 500 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4125 | POWDER, FOR SOLUTION | 125 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4125 | POWDER, FOR SOLUTION | 125 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4125 | POWDER, FOR SOLUTION | 125 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4127 | POWDER, FOR SOLUTION | 250 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4127 | POWDER, FOR SOLUTION | 250 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4127 | POWDER, FOR SOLUTION | 250 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9836 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9836 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9837 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9837 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-2055 | TABLET | 250 mg | ORAL | ANDA | 14 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-8055 | TABLET | 250 mg | ORAL | ANDA | 14 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-8056 | TABLET | 500 mg | ORAL | ANDA | 14 sections |
| Penicillin V Potasium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-1205 | TABLET | 250 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potasium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-1655 | TABLET | 500 mg | OROPHARYNGEAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-075 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 14 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-296 | TABLET | 250 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-297 | TABLET | 500 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-500 | TABLET | 500 mg | ORAL | ANDA | 15 sections |
| Penicillin V Potasium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-975 | TABLET | 500 mg | ORAL | ANDA | 16 sections |
| Penicillin V Potassium | Human Prescription Drug Label | 1 | 16714-234 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 14 sections |
| Penicillin V Potassium | Human Prescription Drug Label | 1 | 16714-234 | TABLET, FILM COATED | 250 mg | ORAL | ANDA | 14 sections |
| Penicillin V Potassium | Human Prescription Drug Label | 1 | 16714-235 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 14 sections |
| Penicillin V Potassium | Human Prescription Drug Label | 1 | 16714-235 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 14 sections |