calcium pantothenate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2055	79-83-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: calcium pantothenate pantothenic acid (+)-Pantothenic acid D-Pantothenic acid Vitamin B5	A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE. Molecular weight: 219.24 Formula: C9H17NO5 CLOGP: -1.49 LIPINSKI: 0 HAC: 6 HDO: 4 TPSA: 106.86 ALOGS: -0.56 ROTB: 6 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

calcium pantothenate
pantothenic acid
(+)-Pantothenic acid
D-Pantothenic acid
Vitamin B5

A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.

Molecular weight: 219.24
Formula: C9H17NO5
CLOGP: -1.49
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 106.86
ALOGS: -0.56
ROTB: 6

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 29, 1993	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Contraindicated product administered	129.79	11.27	3	42053	217645	63229321
Treatment failure	96.24	11.27	10	42046	199033	63247933
Synovitis	94.06	11.27	8	42048	186910	63260056
Systemic lupus erythematosus	88.05	11.27	16	42040	208902	63238064
Product use issue	86.50	11.27	20	42036	220500	63226466
Glossodynia	81.48	11.27	11	42045	178865	63268101
Product dose omission issue	80.66	11.27	338	41718	233975	63212991
Diarrhoea	78.73	11.27	770	41286	714596	62732370
Infusion related reaction	74.07	11.27	35	42021	245486	63201480
Maternal exposure during pregnancy	71.74	11.27	28	42028	220034	63226932

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	74.05	12.21	113	24442	419411	34512965
Fractional exhaled nitric oxide increased	63.10	12.21	25	24530	1057	34931319
Product use in unapproved indication	55.98	12.21	8	24547	117491	34814885
Fatigue	53.51	12.21	443	24112	370210	34562166
Plasma cell myeloma	49.19	12.21	98	24457	41939	34890437
Completed suicide	48.39	12.21	6	24549	98162	34834214
Sensation of foreign body	45.86	12.21	27	24528	2756	34929620
Product dose omission issue	44.38	12.21	184	24371	119527	34812849
Plantar fasciitis	44.26	12.21	24	24531	2092	34930284
Myoglobin blood increased	43.79	12.21	27	24528	2996	34929380

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	132.69	10.55	7	52373	245760	79446248
Toxicity to various agents	100.45	10.55	78	52302	421462	79270546
Off label use	97.95	10.55	290	52090	906925	78785083
Product dose omission issue	91.52	10.55	363	52017	247174	79444834
Product use in unapproved indication	87.06	10.55	28	52352	250331	79441677
Treatment failure	85.68	10.55	7	52373	170479	79521529
Synovitis	73.55	10.55	7	52373	150727	79541281
Device expulsion	70.52	10.55	86	52294	25775	79666233
Fall	69.27	10.55	552	51828	487077	79204931
Drug interaction	68.73	10.55	104	52276	415079	79276929

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A11HA31	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
ATC	D03AX04	DERMATOLOGICALS PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS CICATRIZANTS Other cicatrizants
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:74530	curare poisoning antidote
CHEBI has role	CHEBI:85234	human blood serum metabolites
CHEBI has role	CHEBI:176497	geroprotectors
MeSH PA	D018977	Micronutrients
MeSH PA	D014803	Vitamin B Complex
MeSH PA	D014815	Vitamins

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Ascorbic acid deficiency	indication	76169001
Pantothenic acid deficiency	indication	238128006
Methemoglobinemia	off-label use	38959009	DOID:10783
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Kidney disease	contraindication	90708001	DOID:557
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Hemochromatosis	contraindication	399187006	DOID:2352

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.62	acidic
pKa2	12.98	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
001056	NDDF
001057	NDDF
1260	INN_ID
126225001	SNOMEDCT_US
137-08-6	SECONDARY_CAS_RN
1918	RXNORM
4017627	VANDF
4017672	VANDF
4020312	VUID
4020312	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
BACMIN	HUMAN PRESCRIPTION DRUG LABEL	19	0682-3001	TABLET, COATED	25 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
Centratex	HUMAN PRESCRIPTION DRUG LABEL	13	23359-100	CAPSULE	10 mg	ORAL	unapproved drug other	13 sections
Concept DHA	HUMAN PRESCRIPTION DRUG LABEL	15	52747-621	CAPSULE, LIQUID FILLED	5 mg	ORAL	unapproved drug other	7 sections
Concept DHA	HUMAN PRESCRIPTION DRUG LABEL	15	52747-621	CAPSULE, LIQUID FILLED	5 mg	ORAL	unapproved drug other	7 sections
Concept OB	HUMAN PRESCRIPTION DRUG LABEL	15	52747-620	CAPSULE	7 mg	ORAL	unapproved drug other	13 sections
Concept OB	HUMAN PRESCRIPTION DRUG LABEL	15	52747-620	CAPSULE	7 mg	ORAL	unapproved drug other	13 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	10 mg	ORAL	Unapproved drug other	7 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	10 mg	ORAL	Unapproved drug other	7 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	17856-0010	TABLET, COATED	10 mg	ORAL	Unapproved drug other	8 sections
Dialyvite 3000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-014	TABLET, COATED	10 mg	ORAL	Unapproved drug other	7 sections

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